Association of adrenal function and disease severity in community-acquired pneumonia.
<h4>Introduction</h4>Rapid and accurate risk stratification in patients with community-acquired pneumonia (CAP) is an unmet clinical need. Cortisol to dehydroepiandrosterone (DHEA) ratio was put forward as a prognostic marker in sepsis. We herein validated the prognostic value of the adr...
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2014
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oai:doaj.org-article:db1c4f435a974341b90d7fe0ca139c452021-11-18T08:16:40ZAssociation of adrenal function and disease severity in community-acquired pneumonia.1932-620310.1371/journal.pone.0099518https://doaj.org/article/db1c4f435a974341b90d7fe0ca139c452014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24910975/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Rapid and accurate risk stratification in patients with community-acquired pneumonia (CAP) is an unmet clinical need. Cortisol to dehydroepiandrosterone (DHEA) ratio was put forward as a prognostic marker in sepsis. We herein validated the prognostic value of the adrenal hormones DHEA, DHEA-Sulfate (DHEAS), cortisol/DHEA-, cortisol/DHEAS- and DHEA/DHEAS-ratios in patients with CAP.<h4>Methods</h4>We assessed severity of illness using the pneumonia severity index (PSI) and measured adrenal hormone concentrations in 179 serum samples of prospectively recruited patients hospitalized with CAP. We calculated spearman rank correlation, logistic regression analysis and Kaplan Meier curves to study associations of adrenal hormones and outcomes.<h4>Results</h4>There was a significant correlation between PSI score and total cortisol (r = 0.24, p = 0.001), DHEAS (r = -0.23, p = 0.002), cortisol/DHEA (r = 0.23, p = 0.003), cortisol/DHEAS (r = 0.32, p = <0.0001) and DHEA/DHEAS (r = 0.20, p = 0.009). In age and gender adjusted logistic regression analysis, cortisol (OR:2.8, 95% CI: 1.48-5.28) and DHEA (OR: 2.62,95% CI: 1.28-5.34), but not DHEAS and the different ratios were associated with all-cause mortality. The discriminatory accuracy of cortisol and DHEA in ROC analysis (area under the curve) was 0.74 and 0.61. In Kaplan Meier analysis, patients in the highest deciles of cortisol and DHEA (p = 0.005 and p = 0.015), and to a lesser extent of cortisol/DHEAS ratio (p = 0.081) had a higher risk of death.<h4>Conclusion</h4>Cortisol, DHEAS and their ratios correlate with CAP severity, and cortisol and DHEA predict mortality. Adrenal function in severe pneumonia may be an important factor for CAP outcomes.Cornelia MuellerClaudine A BlumMichael TrummlerDaiana StolzRoland BingisserChristian MuellerMichael TammBeat MuellerPhilipp SchuetzMirjam Christ-CrainPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99518 (2014) |
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Medicine R Science Q |
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Medicine R Science Q Cornelia Mueller Claudine A Blum Michael Trummler Daiana Stolz Roland Bingisser Christian Mueller Michael Tamm Beat Mueller Philipp Schuetz Mirjam Christ-Crain Association of adrenal function and disease severity in community-acquired pneumonia. |
| description |
<h4>Introduction</h4>Rapid and accurate risk stratification in patients with community-acquired pneumonia (CAP) is an unmet clinical need. Cortisol to dehydroepiandrosterone (DHEA) ratio was put forward as a prognostic marker in sepsis. We herein validated the prognostic value of the adrenal hormones DHEA, DHEA-Sulfate (DHEAS), cortisol/DHEA-, cortisol/DHEAS- and DHEA/DHEAS-ratios in patients with CAP.<h4>Methods</h4>We assessed severity of illness using the pneumonia severity index (PSI) and measured adrenal hormone concentrations in 179 serum samples of prospectively recruited patients hospitalized with CAP. We calculated spearman rank correlation, logistic regression analysis and Kaplan Meier curves to study associations of adrenal hormones and outcomes.<h4>Results</h4>There was a significant correlation between PSI score and total cortisol (r = 0.24, p = 0.001), DHEAS (r = -0.23, p = 0.002), cortisol/DHEA (r = 0.23, p = 0.003), cortisol/DHEAS (r = 0.32, p = <0.0001) and DHEA/DHEAS (r = 0.20, p = 0.009). In age and gender adjusted logistic regression analysis, cortisol (OR:2.8, 95% CI: 1.48-5.28) and DHEA (OR: 2.62,95% CI: 1.28-5.34), but not DHEAS and the different ratios were associated with all-cause mortality. The discriminatory accuracy of cortisol and DHEA in ROC analysis (area under the curve) was 0.74 and 0.61. In Kaplan Meier analysis, patients in the highest deciles of cortisol and DHEA (p = 0.005 and p = 0.015), and to a lesser extent of cortisol/DHEAS ratio (p = 0.081) had a higher risk of death.<h4>Conclusion</h4>Cortisol, DHEAS and their ratios correlate with CAP severity, and cortisol and DHEA predict mortality. Adrenal function in severe pneumonia may be an important factor for CAP outcomes. |
| format |
article |
| author |
Cornelia Mueller Claudine A Blum Michael Trummler Daiana Stolz Roland Bingisser Christian Mueller Michael Tamm Beat Mueller Philipp Schuetz Mirjam Christ-Crain |
| author_facet |
Cornelia Mueller Claudine A Blum Michael Trummler Daiana Stolz Roland Bingisser Christian Mueller Michael Tamm Beat Mueller Philipp Schuetz Mirjam Christ-Crain |
| author_sort |
Cornelia Mueller |
| title |
Association of adrenal function and disease severity in community-acquired pneumonia. |
| title_short |
Association of adrenal function and disease severity in community-acquired pneumonia. |
| title_full |
Association of adrenal function and disease severity in community-acquired pneumonia. |
| title_fullStr |
Association of adrenal function and disease severity in community-acquired pneumonia. |
| title_full_unstemmed |
Association of adrenal function and disease severity in community-acquired pneumonia. |
| title_sort |
association of adrenal function and disease severity in community-acquired pneumonia. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/db1c4f435a974341b90d7fe0ca139c45 |
| work_keys_str_mv |
AT corneliamueller associationofadrenalfunctionanddiseaseseverityincommunityacquiredpneumonia AT claudineablum associationofadrenalfunctionanddiseaseseverityincommunityacquiredpneumonia AT michaeltrummler associationofadrenalfunctionanddiseaseseverityincommunityacquiredpneumonia AT daianastolz associationofadrenalfunctionanddiseaseseverityincommunityacquiredpneumonia AT rolandbingisser associationofadrenalfunctionanddiseaseseverityincommunityacquiredpneumonia AT christianmueller associationofadrenalfunctionanddiseaseseverityincommunityacquiredpneumonia AT michaeltamm associationofadrenalfunctionanddiseaseseverityincommunityacquiredpneumonia AT beatmueller associationofadrenalfunctionanddiseaseseverityincommunityacquiredpneumonia AT philippschuetz associationofadrenalfunctionanddiseaseseverityincommunityacquiredpneumonia AT mirjamchristcrain associationofadrenalfunctionanddiseaseseverityincommunityacquiredpneumonia |
| _version_ |
1718422016238813184 |