Coping with centriole loss: pericentriolar material maintenance after centriole degeneration

Shortly after the onset of ciliogenesis in Caenorhabditis elegans sensory neurons, the centrioles/basal bodies undergo degeneration. The fate of the pericentriolar material (PCM) that was associated with those centrioles has, however, remained unknown. Two recent studies by the Dammermann and the Fe...

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Autores principales:	Carla M. C. Abreu, Tiago J. Dantas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/db20c04dfa23459780a3f89f3348458e
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spelling	oai:doaj.org-article:db20c04dfa23459780a3f89f3348458e2021-12-02T17:47:03ZCoping with centriole loss: pericentriolar material maintenance after centriole degeneration10.1038/s42003-021-02243-62399-3642https://doaj.org/article/db20c04dfa23459780a3f89f3348458e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02243-6https://doaj.org/toc/2399-3642Shortly after the onset of ciliogenesis in Caenorhabditis elegans sensory neurons, the centrioles/basal bodies undergo degeneration. The fate of the pericentriolar material (PCM) that was associated with those centrioles has, however, remained unknown. Two recent studies by the Dammermann and the Feldman groups now show that not only does the PCM persist at the ciliary base, it also continues to assemble in the absence of canonical centrioles. Importantly, these neuronal centrosomes retain the ability to function as the cell’s main microtubule-organizing center and support ciliary function.Carla M. C. AbreuTiago J. DantasNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Carla M. C. Abreu Tiago J. Dantas Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
description	Shortly after the onset of ciliogenesis in Caenorhabditis elegans sensory neurons, the centrioles/basal bodies undergo degeneration. The fate of the pericentriolar material (PCM) that was associated with those centrioles has, however, remained unknown. Two recent studies by the Dammermann and the Feldman groups now show that not only does the PCM persist at the ciliary base, it also continues to assemble in the absence of canonical centrioles. Importantly, these neuronal centrosomes retain the ability to function as the cell’s main microtubule-organizing center and support ciliary function.
format	article
author	Carla M. C. Abreu Tiago J. Dantas
author_facet	Carla M. C. Abreu Tiago J. Dantas
author_sort	Carla M. C. Abreu
title	Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
title_short	Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
title_full	Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
title_fullStr	Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
title_full_unstemmed	Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
title_sort	coping with centriole loss: pericentriolar material maintenance after centriole degeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db20c04dfa23459780a3f89f3348458e
work_keys_str_mv	AT carlamcabreu copingwithcentriolelosspericentriolarmaterialmaintenanceaftercentrioledegeneration AT tiagojdantas copingwithcentriolelosspericentriolarmaterialmaintenanceaftercentrioledegeneration
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Coping with centriole loss: pericentriolar material maintenance after centriole degeneration

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