Levels of serum immunomodulators and alterations with electroconvulsive therapy in treatment-resistant major depression

Serkan Zincir,1 Pelin Öztürk,2 Ali Emrah Bilgen,3 Filiz İzci,4 Cihad Yükselir5 1Department of Psychiatry, Gölcük Military Hospital, Kocaeli, 2Psychiatry Clinic, Erenkoy Training and Research Hospital for Psychiatric and Neurological Diseases, Istanbul, 3...

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Autores principales:	Zincir S, Öztürk P, Bilgen AE, İzci F, Yükselir C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	major depression ECT the immune system cytokines Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/db22b26cdbeb40329ffcb90bfda7de6c
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spelling	oai:doaj.org-article:db22b26cdbeb40329ffcb90bfda7de6c2021-12-02T11:02:20ZLevels of serum immunomodulators and alterations with electroconvulsive therapy in treatment-resistant major depression1178-2021https://doaj.org/article/db22b26cdbeb40329ffcb90bfda7de6c2016-06-01T00:00:00Zhttps://www.dovepress.com/levels-of-serum-immunomodulators-and-alterations-with-electroconvulsiv-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Serkan Zincir,1 Pelin Öztürk,2 Ali Emrah Bilgen,3 Filiz İzci,4 Cihad Yükselir5 1Department of Psychiatry, Gölcük Military Hospital, Kocaeli, 2Psychiatry Clinic, Erenkoy Training and Research Hospital for Psychiatric and Neurological Diseases, Istanbul, 3Department of Psychiatry, Etimesgut Military Hospital, Ankara, 4Department of Psychiatry, Istanbul Bilim University, Istanbul, 5Department of Psychiatry, Gulhane Military Medical Faculty, Ankara, Turkey Abstract: Studies in recent years have indicated that neuroimmunological events and immune activation may have a place in the etiology of depression. It has been suggested from data that there is a causal relationship between activation of the immune system and excessive release of proinflammatory cytokines, such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha), and the etiology of depression. Although the mechanism of action of electroconvulsive therapy (ECT) is unclear, there is evidence that it can reduce cytokines and immune system changes. In our study, we aimed to determine how levels of serum immunomodulators were affected by ECT in major depression patients. This study was conducted on 50 patients with treatment-resistant major depression. The data of the patients were compared with 30 healthy individuals with similar demographic characteristics. A clinical response occurred in the patients and at the end of therapy, IL-1, IL-6, TNF-alpha, IL-10, IL-4, and interferon-gamma levels were measured. The disease severity was assessed with the 17-item Hamilton Depression Rating Scale. Data analysis was performed using SPSS Version 15. Significant differences were determined between the patients with major depression and control group with respect to basal serum IL-1, IL-6, TNF-alpha, IL-10, IL-4, and interferon-gamma levels. ECT treatment was shown to reduce these differences. ECT may cause significant changes in the activity of the immune system. The consideration of the relationship between the immune endocrine neurotransmitter systems could contribute to new theories regarding the mechanism of antidepressant treatment and biology of depression. Keywords: the pathophysiology of depression, the immune system, cytokinesZincir SÖztürk PBilgen AEİzci FYükselir CDove Medical Pressarticlemajor depressionECTthe immune systemcytokinesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1389-1396 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	major depression ECT the immune system cytokines Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	major depression ECT the immune system cytokines Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zincir S Öztürk P Bilgen AE İzci F Yükselir C Levels of serum immunomodulators and alterations with electroconvulsive therapy in treatment-resistant major depression
description	Serkan Zincir,1 Pelin Öztürk,2 Ali Emrah Bilgen,3 Filiz İzci,4 Cihad Yükselir5 1Department of Psychiatry, Gölcük Military Hospital, Kocaeli, 2Psychiatry Clinic, Erenkoy Training and Research Hospital for Psychiatric and Neurological Diseases, Istanbul, 3Department of Psychiatry, Etimesgut Military Hospital, Ankara, 4Department of Psychiatry, Istanbul Bilim University, Istanbul, 5Department of Psychiatry, Gulhane Military Medical Faculty, Ankara, Turkey Abstract: Studies in recent years have indicated that neuroimmunological events and immune activation may have a place in the etiology of depression. It has been suggested from data that there is a causal relationship between activation of the immune system and excessive release of proinflammatory cytokines, such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha), and the etiology of depression. Although the mechanism of action of electroconvulsive therapy (ECT) is unclear, there is evidence that it can reduce cytokines and immune system changes. In our study, we aimed to determine how levels of serum immunomodulators were affected by ECT in major depression patients. This study was conducted on 50 patients with treatment-resistant major depression. The data of the patients were compared with 30 healthy individuals with similar demographic characteristics. A clinical response occurred in the patients and at the end of therapy, IL-1, IL-6, TNF-alpha, IL-10, IL-4, and interferon-gamma levels were measured. The disease severity was assessed with the 17-item Hamilton Depression Rating Scale. Data analysis was performed using SPSS Version 15. Significant differences were determined between the patients with major depression and control group with respect to basal serum IL-1, IL-6, TNF-alpha, IL-10, IL-4, and interferon-gamma levels. ECT treatment was shown to reduce these differences. ECT may cause significant changes in the activity of the immune system. The consideration of the relationship between the immune endocrine neurotransmitter systems could contribute to new theories regarding the mechanism of antidepressant treatment and biology of depression. Keywords: the pathophysiology of depression, the immune system, cytokines
format	article
author	Zincir S Öztürk P Bilgen AE İzci F Yükselir C
author_facet	Zincir S Öztürk P Bilgen AE İzci F Yükselir C
author_sort	Zincir S
title	Levels of serum immunomodulators and alterations with electroconvulsive therapy in treatment-resistant major depression
title_short	Levels of serum immunomodulators and alterations with electroconvulsive therapy in treatment-resistant major depression
title_full	Levels of serum immunomodulators and alterations with electroconvulsive therapy in treatment-resistant major depression
title_fullStr	Levels of serum immunomodulators and alterations with electroconvulsive therapy in treatment-resistant major depression
title_full_unstemmed	Levels of serum immunomodulators and alterations with electroconvulsive therapy in treatment-resistant major depression
title_sort	levels of serum immunomodulators and alterations with electroconvulsive therapy in treatment-resistant major depression
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/db22b26cdbeb40329ffcb90bfda7de6c
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Levels of serum immunomodulators and alterations with electroconvulsive therapy in treatment-resistant major depression

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