Night eating model shows time-specific depression-like behavior in the forced swimming test

Abstract The circadian clock system is associated with feeding and mood. Patients with night eating syndrome (NES) delay their eating rhythm and their mood declines during the evening and night, manifesting as time-specific depression. Therefore, we hypothesized that the NES feeding pattern might ca...

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Autores principales:	Atsushi Haraguchi, Miyabi Fukuzawa, Shiho Iwami, Yutaro Nishimura, Hiroaki Motohashi, Yu Tahara, Shigenobu Shibata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/db27e47be6e14bcb943c7473de283376
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spelling	oai:doaj.org-article:db27e47be6e14bcb943c7473de2833762021-12-02T15:08:38ZNight eating model shows time-specific depression-like behavior in the forced swimming test10.1038/s41598-018-19433-82045-2322https://doaj.org/article/db27e47be6e14bcb943c7473de2833762018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19433-8https://doaj.org/toc/2045-2322Abstract The circadian clock system is associated with feeding and mood. Patients with night eating syndrome (NES) delay their eating rhythm and their mood declines during the evening and night, manifesting as time-specific depression. Therefore, we hypothesized that the NES feeding pattern might cause time-specific depression. We established new NES model by restricted feeding with high-fat diet during the inactive period under normal-fat diet ad libitum. The FST (forced swimming test) immobility time in the NES model group was prolonged only after lights-on, corresponding to evening and early night for humans. We examined the effect of the NES feeding pattern on peripheral clocks using PER2::LUCIFERASE knock-in mice and an in vivo monitoring system. Caloric intake during the inactive period would shift the peripheral clock, and might be an important factor in causing the time-specific depression-like behavior. In the NES model group, synthesis of serotonin and norepinephrine were increased, but utilization and metabolism of these monoamines were decreased under stress. Desipramine shortened some mice’s FST immobility time in the NES model group. The present study suggests that the NES feeding pattern causes phase shift of peripheral clocks and malfunction of the monoamine system, which may contribute to the development of time-specific depression.Atsushi HaraguchiMiyabi FukuzawaShiho IwamiYutaro NishimuraHiroaki MotohashiYu TaharaShigenobu ShibataNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Atsushi Haraguchi Miyabi Fukuzawa Shiho Iwami Yutaro Nishimura Hiroaki Motohashi Yu Tahara Shigenobu Shibata Night eating model shows time-specific depression-like behavior in the forced swimming test
description	Abstract The circadian clock system is associated with feeding and mood. Patients with night eating syndrome (NES) delay their eating rhythm and their mood declines during the evening and night, manifesting as time-specific depression. Therefore, we hypothesized that the NES feeding pattern might cause time-specific depression. We established new NES model by restricted feeding with high-fat diet during the inactive period under normal-fat diet ad libitum. The FST (forced swimming test) immobility time in the NES model group was prolonged only after lights-on, corresponding to evening and early night for humans. We examined the effect of the NES feeding pattern on peripheral clocks using PER2::LUCIFERASE knock-in mice and an in vivo monitoring system. Caloric intake during the inactive period would shift the peripheral clock, and might be an important factor in causing the time-specific depression-like behavior. In the NES model group, synthesis of serotonin and norepinephrine were increased, but utilization and metabolism of these monoamines were decreased under stress. Desipramine shortened some mice’s FST immobility time in the NES model group. The present study suggests that the NES feeding pattern causes phase shift of peripheral clocks and malfunction of the monoamine system, which may contribute to the development of time-specific depression.
format	article
author	Atsushi Haraguchi Miyabi Fukuzawa Shiho Iwami Yutaro Nishimura Hiroaki Motohashi Yu Tahara Shigenobu Shibata
author_facet	Atsushi Haraguchi Miyabi Fukuzawa Shiho Iwami Yutaro Nishimura Hiroaki Motohashi Yu Tahara Shigenobu Shibata
author_sort	Atsushi Haraguchi
title	Night eating model shows time-specific depression-like behavior in the forced swimming test
title_short	Night eating model shows time-specific depression-like behavior in the forced swimming test
title_full	Night eating model shows time-specific depression-like behavior in the forced swimming test
title_fullStr	Night eating model shows time-specific depression-like behavior in the forced swimming test
title_full_unstemmed	Night eating model shows time-specific depression-like behavior in the forced swimming test
title_sort	night eating model shows time-specific depression-like behavior in the forced swimming test
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/db27e47be6e14bcb943c7473de283376
work_keys_str_mv	AT atsushiharaguchi nighteatingmodelshowstimespecificdepressionlikebehaviorintheforcedswimmingtest AT miyabifukuzawa nighteatingmodelshowstimespecificdepressionlikebehaviorintheforcedswimmingtest AT shihoiwami nighteatingmodelshowstimespecificdepressionlikebehaviorintheforcedswimmingtest AT yutaronishimura nighteatingmodelshowstimespecificdepressionlikebehaviorintheforcedswimmingtest AT hiroakimotohashi nighteatingmodelshowstimespecificdepressionlikebehaviorintheforcedswimmingtest AT yutahara nighteatingmodelshowstimespecificdepressionlikebehaviorintheforcedswimmingtest AT shigenobushibata nighteatingmodelshowstimespecificdepressionlikebehaviorintheforcedswimmingtest
_version_	1718388092847521792

Night eating model shows time-specific depression-like behavior in the forced swimming test

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