Enzyme mediated synthesis of hybrid polyedric gold nanoparticles

Abstract Large protein complexes carry out some of the most complex activities in biology1,2. Such structures are often assembled spontaneously through the process of self-assembly and have characteristic chemical or biological assets in the cellular mechanisms3. Gold-based nanomaterials have attrac...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Célia Arib, Jolanda Spadavecchia, Marc Lamy de la Chapelle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/db280d33b9b44459a8f2b1f04c711412
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:db280d33b9b44459a8f2b1f04c711412
record_format	dspace
spelling	oai:doaj.org-article:db280d33b9b44459a8f2b1f04c7114122021-12-02T14:06:58ZEnzyme mediated synthesis of hybrid polyedric gold nanoparticles10.1038/s41598-021-81751-12045-2322https://doaj.org/article/db280d33b9b44459a8f2b1f04c7114122021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81751-1https://doaj.org/toc/2045-2322Abstract Large protein complexes carry out some of the most complex activities in biology1,2. Such structures are often assembled spontaneously through the process of self-assembly and have characteristic chemical or biological assets in the cellular mechanisms3. Gold-based nanomaterials have attracted much attention in many areas of chemistry, physics and biosciences because of their size- and shape-dependent optic, electric, and catalytic properties. Here we report for the first time a one step synthesis in which Manganese Superoxide Dismutase protein plays a key role in the reduction of gold salts via the use of a Good's buffer (HEPES) to produce gold nanoparticles, compared to other proteins as catalase (CAT) and bovine serum albumin (BSA).We prove that this effect is directly related with the biological activities of the proteins that have an effect on the gold reduction mechanisms. Such synthesis route also induces the integration of proteins directly in the AuNPs that are intrinsically safe by design using a one-step production method. This is an important finding that will have uses in various applications, particularly in the green synthesis of novel nanomaterials.Célia AribJolanda SpadavecchiaMarc Lamy de la ChapelleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Célia Arib Jolanda Spadavecchia Marc Lamy de la Chapelle Enzyme mediated synthesis of hybrid polyedric gold nanoparticles
description	Abstract Large protein complexes carry out some of the most complex activities in biology1,2. Such structures are often assembled spontaneously through the process of self-assembly and have characteristic chemical or biological assets in the cellular mechanisms3. Gold-based nanomaterials have attracted much attention in many areas of chemistry, physics and biosciences because of their size- and shape-dependent optic, electric, and catalytic properties. Here we report for the first time a one step synthesis in which Manganese Superoxide Dismutase protein plays a key role in the reduction of gold salts via the use of a Good's buffer (HEPES) to produce gold nanoparticles, compared to other proteins as catalase (CAT) and bovine serum albumin (BSA).We prove that this effect is directly related with the biological activities of the proteins that have an effect on the gold reduction mechanisms. Such synthesis route also induces the integration of proteins directly in the AuNPs that are intrinsically safe by design using a one-step production method. This is an important finding that will have uses in various applications, particularly in the green synthesis of novel nanomaterials.
format	article
author	Célia Arib Jolanda Spadavecchia Marc Lamy de la Chapelle
author_facet	Célia Arib Jolanda Spadavecchia Marc Lamy de la Chapelle
author_sort	Célia Arib
title	Enzyme mediated synthesis of hybrid polyedric gold nanoparticles
title_short	Enzyme mediated synthesis of hybrid polyedric gold nanoparticles
title_full	Enzyme mediated synthesis of hybrid polyedric gold nanoparticles
title_fullStr	Enzyme mediated synthesis of hybrid polyedric gold nanoparticles
title_full_unstemmed	Enzyme mediated synthesis of hybrid polyedric gold nanoparticles
title_sort	enzyme mediated synthesis of hybrid polyedric gold nanoparticles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db280d33b9b44459a8f2b1f04c711412
work_keys_str_mv	AT celiaarib enzymemediatedsynthesisofhybridpolyedricgoldnanoparticles AT jolandaspadavecchia enzymemediatedsynthesisofhybridpolyedricgoldnanoparticles AT marclamydelachapelle enzymemediatedsynthesisofhybridpolyedricgoldnanoparticles
_version_	1718391993794560000

Enzyme mediated synthesis of hybrid polyedric gold nanoparticles

Ejemplares similares