Neuroendocrine regulation and ovarian reserve in HIV-infected women with reproductive disorders

Background: Among the subjects of the Russian Federation, Irkutsk region is an area with an unfavorable epidemiological situation for HIV-infection. Women living with HIV in Russia and visiting AIDS-centers represent a socially and economically active part of the population are at a young reproducti...

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Main Authors:	E. V. Genich, O. Y. Leshenko, M. A. Darenskaya, L. F. Sholokhov
Format:	article
Language:	RU
Published:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Subjects:	hiv-infection women reproductive disorders neuroendocrine disorders Science Q
Online Access:	https://doaj.org/article/db28dd954f164bdf865c728de0b774a2
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spelling	oai:doaj.org-article:db28dd954f164bdf865c728de0b774a22021-11-23T06:14:40ZNeuroendocrine regulation and ovarian reserve in HIV-infected women with reproductive disorders2541-94202587-959610.29413/ABS.2018-3.3.18https://doaj.org/article/db28dd954f164bdf865c728de0b774a22018-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/594https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background: Among the subjects of the Russian Federation, Irkutsk region is an area with an unfavorable epidemiological situation for HIV-infection. Women living with HIV in Russia and visiting AIDS-centers represent a socially and economically active part of the population are at a young reproductive age and plan to have children. Aims: to study the state of the neuroendocrine system and the ovarian reserve in HIV-infected women with reproductive disorders. Materials and methods. We examined in 17 HIV-infected women with reproductive disorders and 33 women with HIV-infection and reproductive health at the age of 18-45 years (mean age 31,1 ± 4,4 years). The determination of hormone levels was carried out by a competitive solid-phase enzyme-linked immunosorbent assay. Results. The obtained results testify to neuroendocrine disorders in the form of a decrease in the level of total testosterone, 17-OH progesterone, dehydroepiandrosterone sulfate, as a manifestation of androgen deficiency of the body, as a result of ovarian dysfunction. Decrease in the level of Anti-Mullerian Hormone and increase the content of follicle-stimulating hormone, as a manifestation of the beginning of early menopause or a factor leading to infertility. Conclusions. The results of this study show that a woman's body on the background of HIV-infection reveals disorders of the neuroendocrine system dysfunction and decreased ovarian ovarian reserve, and as a result, reproductive disorders.E. V. GenichO. Y. LeshenkoM. A. DarenskayaL. F. SholokhovScientific Сentre for Family Health and Human Reproduction Problemsarticlehiv-infectionwomenreproductive disordersneuroendocrine disordersScienceQRUActa Biomedica Scientifica, Vol 3, Iss 3, Pp 116-120 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	hiv-infection women reproductive disorders neuroendocrine disorders Science Q
spellingShingle	hiv-infection women reproductive disorders neuroendocrine disorders Science Q E. V. Genich O. Y. Leshenko M. A. Darenskaya L. F. Sholokhov Neuroendocrine regulation and ovarian reserve in HIV-infected women with reproductive disorders
description	Background: Among the subjects of the Russian Federation, Irkutsk region is an area with an unfavorable epidemiological situation for HIV-infection. Women living with HIV in Russia and visiting AIDS-centers represent a socially and economically active part of the population are at a young reproductive age and plan to have children. Aims: to study the state of the neuroendocrine system and the ovarian reserve in HIV-infected women with reproductive disorders. Materials and methods. We examined in 17 HIV-infected women with reproductive disorders and 33 women with HIV-infection and reproductive health at the age of 18-45 years (mean age 31,1 ± 4,4 years). The determination of hormone levels was carried out by a competitive solid-phase enzyme-linked immunosorbent assay. Results. The obtained results testify to neuroendocrine disorders in the form of a decrease in the level of total testosterone, 17-OH progesterone, dehydroepiandrosterone sulfate, as a manifestation of androgen deficiency of the body, as a result of ovarian dysfunction. Decrease in the level of Anti-Mullerian Hormone and increase the content of follicle-stimulating hormone, as a manifestation of the beginning of early menopause or a factor leading to infertility. Conclusions. The results of this study show that a woman's body on the background of HIV-infection reveals disorders of the neuroendocrine system dysfunction and decreased ovarian ovarian reserve, and as a result, reproductive disorders.
format	article
author	E. V. Genich O. Y. Leshenko M. A. Darenskaya L. F. Sholokhov
author_facet	E. V. Genich O. Y. Leshenko M. A. Darenskaya L. F. Sholokhov
author_sort	E. V. Genich
title	Neuroendocrine regulation and ovarian reserve in HIV-infected women with reproductive disorders
title_short	Neuroendocrine regulation and ovarian reserve in HIV-infected women with reproductive disorders
title_full	Neuroendocrine regulation and ovarian reserve in HIV-infected women with reproductive disorders
title_fullStr	Neuroendocrine regulation and ovarian reserve in HIV-infected women with reproductive disorders
title_full_unstemmed	Neuroendocrine regulation and ovarian reserve in HIV-infected women with reproductive disorders
title_sort	neuroendocrine regulation and ovarian reserve in hiv-infected women with reproductive disorders
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/db28dd954f164bdf865c728de0b774a2
work_keys_str_mv	AT evgenich neuroendocrineregulationandovarianreserveinhivinfectedwomenwithreproductivedisorders AT oyleshenko neuroendocrineregulationandovarianreserveinhivinfectedwomenwithreproductivedisorders AT madarenskaya neuroendocrineregulationandovarianreserveinhivinfectedwomenwithreproductivedisorders AT lfsholokhov neuroendocrineregulationandovarianreserveinhivinfectedwomenwithreproductivedisorders
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Neuroendocrine regulation and ovarian reserve in HIV-infected women with reproductive disorders

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