In vitro implementation of robust gene regulation in a synthetic biomolecular integral controller

Feedback mechanisms for synthetic gene circuits are necessary to provide robustness to external perturbations. Here the authors validate a biomolecular controller based on a sigma and anti-sigma factor to achieve stable gene expression in the face of external disturbances in an in vitro synthetic ge...

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Autores principales:	Deepak K. Agrawal, Ryan Marshall, Vincent Noireaux, Eduardo D Sontag
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db296cdc1e4f40eeb70fd1ef4b8ff017
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spelling	oai:doaj.org-article:db296cdc1e4f40eeb70fd1ef4b8ff0172021-12-02T15:36:21ZIn vitro implementation of robust gene regulation in a synthetic biomolecular integral controller10.1038/s41467-019-13626-z2041-1723https://doaj.org/article/db296cdc1e4f40eeb70fd1ef4b8ff0172019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13626-zhttps://doaj.org/toc/2041-1723Feedback mechanisms for synthetic gene circuits are necessary to provide robustness to external perturbations. Here the authors validate a biomolecular controller based on a sigma and anti-sigma factor to achieve stable gene expression in the face of external disturbances in an in vitro synthetic gene circuit.Deepak K. AgrawalRyan MarshallVincent NoireauxEduardo D SontagNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deepak K. Agrawal Ryan Marshall Vincent Noireaux Eduardo D Sontag In vitro implementation of robust gene regulation in a synthetic biomolecular integral controller
description	Feedback mechanisms for synthetic gene circuits are necessary to provide robustness to external perturbations. Here the authors validate a biomolecular controller based on a sigma and anti-sigma factor to achieve stable gene expression in the face of external disturbances in an in vitro synthetic gene circuit.
format	article
author	Deepak K. Agrawal Ryan Marshall Vincent Noireaux Eduardo D Sontag
author_facet	Deepak K. Agrawal Ryan Marshall Vincent Noireaux Eduardo D Sontag
author_sort	Deepak K. Agrawal
title	In vitro implementation of robust gene regulation in a synthetic biomolecular integral controller
title_short	In vitro implementation of robust gene regulation in a synthetic biomolecular integral controller
title_full	In vitro implementation of robust gene regulation in a synthetic biomolecular integral controller
title_fullStr	In vitro implementation of robust gene regulation in a synthetic biomolecular integral controller
title_full_unstemmed	In vitro implementation of robust gene regulation in a synthetic biomolecular integral controller
title_sort	in vitro implementation of robust gene regulation in a synthetic biomolecular integral controller
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/db296cdc1e4f40eeb70fd1ef4b8ff017
work_keys_str_mv	AT deepakkagrawal invitroimplementationofrobustgeneregulationinasyntheticbiomolecularintegralcontroller AT ryanmarshall invitroimplementationofrobustgeneregulationinasyntheticbiomolecularintegralcontroller AT vincentnoireaux invitroimplementationofrobustgeneregulationinasyntheticbiomolecularintegralcontroller AT eduardodsontag invitroimplementationofrobustgeneregulationinasyntheticbiomolecularintegralcontroller
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In vitro implementation of robust gene regulation in a synthetic biomolecular integral controller

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