In vitro implementation of robust gene regulation in a synthetic biomolecular integral controller
Feedback mechanisms for synthetic gene circuits are necessary to provide robustness to external perturbations. Here the authors validate a biomolecular controller based on a sigma and anti-sigma factor to achieve stable gene expression in the face of external disturbances in an in vitro synthetic ge...
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| Main Authors: | Deepak K. Agrawal, Ryan Marshall, Vincent Noireaux, Eduardo D Sontag |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2019
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| Subjects: | |
| Online Access: | https://doaj.org/article/db296cdc1e4f40eeb70fd1ef4b8ff017 |
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