In vitro implementation of robust gene regulation in a synthetic biomolecular integral controller

Feedback mechanisms for synthetic gene circuits are necessary to provide robustness to external perturbations. Here the authors validate a biomolecular controller based on a sigma and anti-sigma factor to achieve stable gene expression in the face of external disturbances in an in vitro synthetic ge...

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Bibliographic Details
Main Authors: Deepak K. Agrawal, Ryan Marshall, Vincent Noireaux, Eduardo D Sontag
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Q
Online Access:https://doaj.org/article/db296cdc1e4f40eeb70fd1ef4b8ff017
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