ReIMAGINE: a prostate cancer research consortium with added value through its patient and public involvement and engagement

Plain English Summary One in eight men will be diagnosed with prostate cancer (PCa). Most will not die of it, but our ability to identify those men whose cancer poses the greatest threat to life has, thus far, been poor. Some men are diagnosed with small cancers which will never cause them a problem...

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Autores principales:	S. Green, S. Tuck, J. Long, T. Green, A. Green, P. Ellis, A. Haire, C. Moss, F. Cahill, N. McCartan, L. Brown, A. Santaolalla, T. Marsden, M. Rodriquez Justo, J. Hadley, S. Punwani, G. Attard, H. Ahmed, C. M. Moore, M. Emberton, M. Van Hemelrijck
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Patient and public involvement Patient and public engagement Cancer Prostate cancer Study design Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/db2ae637d80743899a426c8e35aabea3
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spelling	oai:doaj.org-article:db2ae637d80743899a426c8e35aabea32021-11-21T12:14:58ZReIMAGINE: a prostate cancer research consortium with added value through its patient and public involvement and engagement10.1186/s40900-021-00322-w2056-7529https://doaj.org/article/db2ae637d80743899a426c8e35aabea32021-11-01T00:00:00Zhttps://doi.org/10.1186/s40900-021-00322-whttps://doaj.org/toc/2056-7529Plain English Summary One in eight men will be diagnosed with prostate cancer (PCa). Most will not die of it, but our ability to identify those men whose cancer poses the greatest threat to life has, thus far, been poor. Some men are diagnosed with small cancers which will never cause them a problem, some will have treatment which is unnecessary, others will have their cancers missed, and others will be misclassified as either having low risk cancer and will therefore miss out on the appropriate treatment, or told their cancer is high risk and have unnecessary treatment. Nowhere else in modern medicine are these errors of over-diagnosis, over-treatment, missed-diagnoses, and poor risk-stratification more common. The ReIMAGINE Consortium has been developed to undertake discoveries that will correct these four key errors in the PCa diagnostic pathway. We will investigate how to best identify which men have, or will develop, aggressive prostate cancer using imaging combined with advanced biomarker analyses of blood and urine (i.e., OMICs technologies such as whole genome sequencing, targeted sequencing (e.g.: = , methylation). We will achieve this by building on established partnerships between patients, advocacy organisations, clinicians, imaging experts, molecular biologists, methodologists, and a broad range of industrial partners. The Patient and Public Involvement (PPI) sub-committee is an integral part of the study workflow, contributing to study design and recruitment, results analysis, and dissemination. The committee, led by a funded PPI co-ordinator and a patient chair, have given invaluable insight into the study modifications due to COVID-19 restrictions.S. GreenS. TuckJ. LongT. GreenA. GreenP. EllisA. HaireC. MossF. CahillN. McCartanL. BrownA. SantaolallaT. MarsdenM. Rodriquez JustoJ. HadleyS. PunwaniG. AttardH. AhmedC. M. MooreM. EmbertonM. Van HemelrijckBMCarticlePatient and public involvementPatient and public engagementCancerProstate cancerStudy designMedicineRMedicine (General)R5-920ENResearch Involvement and Engagement, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Patient and public involvement Patient and public engagement Cancer Prostate cancer Study design Medicine R Medicine (General) R5-920
spellingShingle	Patient and public involvement Patient and public engagement Cancer Prostate cancer Study design Medicine R Medicine (General) R5-920 S. Green S. Tuck J. Long T. Green A. Green P. Ellis A. Haire C. Moss F. Cahill N. McCartan L. Brown A. Santaolalla T. Marsden M. Rodriquez Justo J. Hadley S. Punwani G. Attard H. Ahmed C. M. Moore M. Emberton M. Van Hemelrijck ReIMAGINE: a prostate cancer research consortium with added value through its patient and public involvement and engagement
description	Plain English Summary One in eight men will be diagnosed with prostate cancer (PCa). Most will not die of it, but our ability to identify those men whose cancer poses the greatest threat to life has, thus far, been poor. Some men are diagnosed with small cancers which will never cause them a problem, some will have treatment which is unnecessary, others will have their cancers missed, and others will be misclassified as either having low risk cancer and will therefore miss out on the appropriate treatment, or told their cancer is high risk and have unnecessary treatment. Nowhere else in modern medicine are these errors of over-diagnosis, over-treatment, missed-diagnoses, and poor risk-stratification more common. The ReIMAGINE Consortium has been developed to undertake discoveries that will correct these four key errors in the PCa diagnostic pathway. We will investigate how to best identify which men have, or will develop, aggressive prostate cancer using imaging combined with advanced biomarker analyses of blood and urine (i.e., OMICs technologies such as whole genome sequencing, targeted sequencing (e.g.: = , methylation). We will achieve this by building on established partnerships between patients, advocacy organisations, clinicians, imaging experts, molecular biologists, methodologists, and a broad range of industrial partners. The Patient and Public Involvement (PPI) sub-committee is an integral part of the study workflow, contributing to study design and recruitment, results analysis, and dissemination. The committee, led by a funded PPI co-ordinator and a patient chair, have given invaluable insight into the study modifications due to COVID-19 restrictions.
format	article
author	S. Green S. Tuck J. Long T. Green A. Green P. Ellis A. Haire C. Moss F. Cahill N. McCartan L. Brown A. Santaolalla T. Marsden M. Rodriquez Justo J. Hadley S. Punwani G. Attard H. Ahmed C. M. Moore M. Emberton M. Van Hemelrijck
author_facet	S. Green S. Tuck J. Long T. Green A. Green P. Ellis A. Haire C. Moss F. Cahill N. McCartan L. Brown A. Santaolalla T. Marsden M. Rodriquez Justo J. Hadley S. Punwani G. Attard H. Ahmed C. M. Moore M. Emberton M. Van Hemelrijck
author_sort	S. Green
title	ReIMAGINE: a prostate cancer research consortium with added value through its patient and public involvement and engagement
title_short	ReIMAGINE: a prostate cancer research consortium with added value through its patient and public involvement and engagement
title_full	ReIMAGINE: a prostate cancer research consortium with added value through its patient and public involvement and engagement
title_fullStr	ReIMAGINE: a prostate cancer research consortium with added value through its patient and public involvement and engagement
title_full_unstemmed	ReIMAGINE: a prostate cancer research consortium with added value through its patient and public involvement and engagement
title_sort	reimagine: a prostate cancer research consortium with added value through its patient and public involvement and engagement
publisher	BMC
publishDate	2021
url	https://doaj.org/article/db2ae637d80743899a426c8e35aabea3
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ReIMAGINE: a prostate cancer research consortium with added value through its patient and public involvement and engagement

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