Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles

Kaikai Bai,1,2,* Bihong Hong,1,2,* Ran Tan,1,2 Jianlin He,1,2 Zhuan Hong1,2 1Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, Republic of China; 2Technical Innovation Center for Utilization of Marine Biological Resources, Ministry of Natural Resources, Xiamen 361005, Pe...

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Autores principales:	Bai K, Hong B, Tan R, He J, Hong Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	selenium nanoparticles gastric mucosal injury gastroprotection antioxidant Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/db2b4d0d301a4197845c91ae3833362d
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spelling	oai:doaj.org-article:db2b4d0d301a4197845c91ae3833362d2021-12-02T06:39:42ZSelenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles1178-2013https://doaj.org/article/db2b4d0d301a4197845c91ae3833362d2020-02-01T00:00:00Zhttps://www.dovepress.com/selenium-nanoparticles-embedded-chitosan-microspheres-and-their-effect-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Kaikai Bai,1,2,* Bihong Hong,1,2,* Ran Tan,1,2 Jianlin He,1,2 Zhuan Hong1,2 1Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, Republic of China; 2Technical Innovation Center for Utilization of Marine Biological Resources, Ministry of Natural Resources, Xiamen 361005, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kaikai BaiThird Institute of Oceanography, Ministry of Natural Resources, No. 184, Daxue Road, Siming District, Xiamen, Fujian 361005, People’s Republic of ChinaTel +86 592 2195309Fax +86 592 2190818Email kkbai@tio.org.cnBackground: Selenium (Se) is an indispensable trace element required for animals and human beings, whereas Se-deficiency can accelerate the development of acute gastric injury induced by over-consumption of alcohol. Selenium nanoparticles (SeNPs), as a special Se-supplement with favorable properties and unique bioactivities, are expected to play a passive role in gastroprotection. To the best of our knowledge, the gastroprotective potential of SeNPs is unknown and also, a rapid preparation of orally stable SeNPs available for prospective commercial application in the clinic is needed. Thus, SeNPs-embedded chitosan microspheres (SeNPs-CM) were developed to deliver SeNPs, and their gastroprotective potential was evaluated.Results: Herein, a rapid, eco-friendly and economic preparation process, composed of synthesis of SeNPs decorated by chitosan (CS), purification of CS-SeNPs by ultra-filtration (UF) and spray-drying of the purified CS-SeNPs, was introduced to prepare SeNPs-CM. The uniformly distributed SeNPs with a nanosize range of 60 nm were loaded into CS-microspheres, and they could be released from the microspheres in gastric conditions. In addition, SeNPs-CM were safer than selenite in terms of Se dose, with a LD50 of around 8-fold of that of selenite, and it could efficiently enhance the Se retention in Se-deficient Wistar rats. Furthermore, SeNPs-CM pre-treatment might significantly attenuate the ethanol-induced gastric mucosal damage, based on histological evaluation. It might be partly attributed to the systematic antioxidant activities of SeNPs-CM, reflected by the reduction in lipid peroxidation, the augmentation in antioxidant enzymatic activity as well as decreasing aggressive nitric oxides (NO).Conclusion: SeNPs-CM could be taken into consideration as a prospective Se-supplement for the oral delivery of SeNPs, with prominent gastroprotective effect against ethanol-induced mucosal injury.Keywords: selenium nanoparticles, gastric mucosal injury, gastroprotection, antioxidantBai KHong BTan RHe JHong ZDove Medical Pressarticleselenium nanoparticlesgastric mucosal injurygastroprotectionantioxidantMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 1187-1203 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	selenium nanoparticles gastric mucosal injury gastroprotection antioxidant Medicine (General) R5-920
spellingShingle	selenium nanoparticles gastric mucosal injury gastroprotection antioxidant Medicine (General) R5-920 Bai K Hong B Tan R He J Hong Z Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles
description	Kaikai Bai,1,2,* Bihong Hong,1,2,* Ran Tan,1,2 Jianlin He,1,2 Zhuan Hong1,2 1Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, Republic of China; 2Technical Innovation Center for Utilization of Marine Biological Resources, Ministry of Natural Resources, Xiamen 361005, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kaikai BaiThird Institute of Oceanography, Ministry of Natural Resources, No. 184, Daxue Road, Siming District, Xiamen, Fujian 361005, People’s Republic of ChinaTel +86 592 2195309Fax +86 592 2190818Email kkbai@tio.org.cnBackground: Selenium (Se) is an indispensable trace element required for animals and human beings, whereas Se-deficiency can accelerate the development of acute gastric injury induced by over-consumption of alcohol. Selenium nanoparticles (SeNPs), as a special Se-supplement with favorable properties and unique bioactivities, are expected to play a passive role in gastroprotection. To the best of our knowledge, the gastroprotective potential of SeNPs is unknown and also, a rapid preparation of orally stable SeNPs available for prospective commercial application in the clinic is needed. Thus, SeNPs-embedded chitosan microspheres (SeNPs-CM) were developed to deliver SeNPs, and their gastroprotective potential was evaluated.Results: Herein, a rapid, eco-friendly and economic preparation process, composed of synthesis of SeNPs decorated by chitosan (CS), purification of CS-SeNPs by ultra-filtration (UF) and spray-drying of the purified CS-SeNPs, was introduced to prepare SeNPs-CM. The uniformly distributed SeNPs with a nanosize range of 60 nm were loaded into CS-microspheres, and they could be released from the microspheres in gastric conditions. In addition, SeNPs-CM were safer than selenite in terms of Se dose, with a LD50 of around 8-fold of that of selenite, and it could efficiently enhance the Se retention in Se-deficient Wistar rats. Furthermore, SeNPs-CM pre-treatment might significantly attenuate the ethanol-induced gastric mucosal damage, based on histological evaluation. It might be partly attributed to the systematic antioxidant activities of SeNPs-CM, reflected by the reduction in lipid peroxidation, the augmentation in antioxidant enzymatic activity as well as decreasing aggressive nitric oxides (NO).Conclusion: SeNPs-CM could be taken into consideration as a prospective Se-supplement for the oral delivery of SeNPs, with prominent gastroprotective effect against ethanol-induced mucosal injury.Keywords: selenium nanoparticles, gastric mucosal injury, gastroprotection, antioxidant
format	article
author	Bai K Hong B Tan R He J Hong Z
author_facet	Bai K Hong B Tan R He J Hong Z
author_sort	Bai K
title	Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles
title_short	Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles
title_full	Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles
title_fullStr	Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles
title_full_unstemmed	Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles
title_sort	selenium nanoparticles-embedded chitosan microspheres and their effects upon alcohol-induced gastric mucosal injury in rats: rapid preparation, oral delivery, and gastroprotective potential of selenium nanoparticles
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/db2b4d0d301a4197845c91ae3833362d
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_version_	1718399841309032448

Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles

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