The Expression of Programmed Death Ligand 1 and Vimentin in Resected Non-Metastatic Non-Small-Cell Lung Cancer: Interplay and Prognostic Effects
Programmed death ligand 1 (PD-L1) is an immune checkpoint with a role in cancer-related immune evasion. It is a target for cancer immunotherapy and its expression is detected for the use of some immune checkpoint inhibitors in advanced non-small cell lung cancer patients (NSCLC). Vimentin is a key c...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:db302667216f4985b2e27f223631df392021-12-01T16:59:46ZThe Expression of Programmed Death Ligand 1 and Vimentin in Resected Non-Metastatic Non-Small-Cell Lung Cancer: Interplay and Prognostic Effects2296-634X10.3389/fcell.2021.772216https://doaj.org/article/db302667216f4985b2e27f223631df392021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.772216/fullhttps://doaj.org/toc/2296-634XProgrammed death ligand 1 (PD-L1) is an immune checkpoint with a role in cancer-related immune evasion. It is a target for cancer immunotherapy and its expression is detected for the use of some immune checkpoint inhibitors in advanced non-small cell lung cancer patients (NSCLC). Vimentin is a key component of the epithelial-to-mesenchymal transition phenotype. Its expression has negative prognostic effects in NSCLC. In this study, we retrospectively evaluated PD-L1 and vimentin expression in tumor cells, immune infiltrate and PD-L1 positive immune infiltrate via immunohistochemistry in tissue samples from resected non-metastatic NSCLC patients. We explored the interplay between PD-L1 and vimentin expression through Spearman’s correlation test. We performed univariate analysis through the Cox models for demographic and clinico-pathological variables, and also for dichotomized biomarkers, i.e., PD-L1 and vimentin in tumor cells, both with 1 and 50% cutoffs. We used Kaplan-Meier method to estimate the overall survival, comparing both vimentin and PD-L1 positive patients with all the others. We found a weak positive correlation between PD-L1 and vimentin expressions in tumor cells (r = 0.25; p = 0.001). We also observed a statistically not significant trend towards a shorter overall survival in patients with both PD-L1 and vimentin expression >1% (HR = 1.36; 95% CI: 0.96–1.93, p = 0.087). In conclusion, these findings suggest that interplay between PD-L1 and vimentin may exist in non-metastatic NSCLC patients and the positivity of both markers in tumor tissue is associated with a trend towards a worse prognosis.Sara BravacciniGiuseppe BronteElisabetta PetracciMaurizio PuccettiManolo D’ArcangeloSara RavaioliMaria Maddalena TumedeiRoberta MaltoniAngelo DelmonteFederico CappuzzoLucio CrinòFrontiers Media S.A.articleNSCLCPD-L1vimentinimmune infiltratenon-metastatic (M0) patientsBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021) |
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NSCLC PD-L1 vimentin immune infiltrate non-metastatic (M0) patients Biology (General) QH301-705.5 |
| spellingShingle |
NSCLC PD-L1 vimentin immune infiltrate non-metastatic (M0) patients Biology (General) QH301-705.5 Sara Bravaccini Giuseppe Bronte Elisabetta Petracci Maurizio Puccetti Manolo D’Arcangelo Sara Ravaioli Maria Maddalena Tumedei Roberta Maltoni Angelo Delmonte Federico Cappuzzo Lucio Crinò The Expression of Programmed Death Ligand 1 and Vimentin in Resected Non-Metastatic Non-Small-Cell Lung Cancer: Interplay and Prognostic Effects |
| description |
Programmed death ligand 1 (PD-L1) is an immune checkpoint with a role in cancer-related immune evasion. It is a target for cancer immunotherapy and its expression is detected for the use of some immune checkpoint inhibitors in advanced non-small cell lung cancer patients (NSCLC). Vimentin is a key component of the epithelial-to-mesenchymal transition phenotype. Its expression has negative prognostic effects in NSCLC. In this study, we retrospectively evaluated PD-L1 and vimentin expression in tumor cells, immune infiltrate and PD-L1 positive immune infiltrate via immunohistochemistry in tissue samples from resected non-metastatic NSCLC patients. We explored the interplay between PD-L1 and vimentin expression through Spearman’s correlation test. We performed univariate analysis through the Cox models for demographic and clinico-pathological variables, and also for dichotomized biomarkers, i.e., PD-L1 and vimentin in tumor cells, both with 1 and 50% cutoffs. We used Kaplan-Meier method to estimate the overall survival, comparing both vimentin and PD-L1 positive patients with all the others. We found a weak positive correlation between PD-L1 and vimentin expressions in tumor cells (r = 0.25; p = 0.001). We also observed a statistically not significant trend towards a shorter overall survival in patients with both PD-L1 and vimentin expression >1% (HR = 1.36; 95% CI: 0.96–1.93, p = 0.087). In conclusion, these findings suggest that interplay between PD-L1 and vimentin may exist in non-metastatic NSCLC patients and the positivity of both markers in tumor tissue is associated with a trend towards a worse prognosis. |
| format |
article |
| author |
Sara Bravaccini Giuseppe Bronte Elisabetta Petracci Maurizio Puccetti Manolo D’Arcangelo Sara Ravaioli Maria Maddalena Tumedei Roberta Maltoni Angelo Delmonte Federico Cappuzzo Lucio Crinò |
| author_facet |
Sara Bravaccini Giuseppe Bronte Elisabetta Petracci Maurizio Puccetti Manolo D’Arcangelo Sara Ravaioli Maria Maddalena Tumedei Roberta Maltoni Angelo Delmonte Federico Cappuzzo Lucio Crinò |
| author_sort |
Sara Bravaccini |
| title |
The Expression of Programmed Death Ligand 1 and Vimentin in Resected Non-Metastatic Non-Small-Cell Lung Cancer: Interplay and Prognostic Effects |
| title_short |
The Expression of Programmed Death Ligand 1 and Vimentin in Resected Non-Metastatic Non-Small-Cell Lung Cancer: Interplay and Prognostic Effects |
| title_full |
The Expression of Programmed Death Ligand 1 and Vimentin in Resected Non-Metastatic Non-Small-Cell Lung Cancer: Interplay and Prognostic Effects |
| title_fullStr |
The Expression of Programmed Death Ligand 1 and Vimentin in Resected Non-Metastatic Non-Small-Cell Lung Cancer: Interplay and Prognostic Effects |
| title_full_unstemmed |
The Expression of Programmed Death Ligand 1 and Vimentin in Resected Non-Metastatic Non-Small-Cell Lung Cancer: Interplay and Prognostic Effects |
| title_sort |
expression of programmed death ligand 1 and vimentin in resected non-metastatic non-small-cell lung cancer: interplay and prognostic effects |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/db302667216f4985b2e27f223631df39 |
| work_keys_str_mv |
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