Trends of variation of the laboratory parameters during the course of COVID-19 Illness

Background: The coronavirus pandemic which had its origin in the Wuhan China has been spreading across the globe with far reaching complications and a variable clinical course. A variation of the laboratory parameters during the disease course remains a constant parameter to monitor the disease cour...

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Autores principales:	Anjali Goyal, Chandni Gadara, Heta Patel, Misha Antani, Nilay Suthar
Formato:	article
Lenguaje:	EN
Publicado:	Manipal College of Medical Sciences, Pokhara 2021
Materias:	covid-19 laboratory parameters comparison Medicine R
Acceso en línea:	https://doi.org/10.3126/ajms.v12i12.39185 https://doaj.org/article/db3085e14a6343aab9f486b7c4e0f55c
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spelling	oai:doaj.org-article:db3085e14a6343aab9f486b7c4e0f55c2021-12-01T11:35:28ZTrends of variation of the laboratory parameters during the course of COVID-19 Illnesshttps://doi.org/10.3126/ajms.v12i12.391852467-91002091-0576https://doaj.org/article/db3085e14a6343aab9f486b7c4e0f55c2021-12-01T00:00:00Zhttps://www.nepjol.info/index.php/AJMS/article/view/39185https://doaj.org/toc/2467-9100https://doaj.org/toc/2091-0576Background: The coronavirus pandemic which had its origin in the Wuhan China has been spreading across the globe with far reaching complications and a variable clinical course. A variation of the laboratory parameters during the disease course remains a constant parameter to monitor the disease course and progression. Since the laboratory parameters are standardized globally, these may also act as uniform guidelines for the patients monitoring and treatment. Aims and Objectives: The aim of the study was to serial charting of the laboratory parameters in the recovered and expired patients of COVID-19 and to determine an associated prognostic significance. Materials and Methods: A retrospective observational study from the laboratory and medical records was conducted on the patients admitted from March 17, 2020, to May 31, 2020, at the tertiary care center dedicated to the treatment of RT-PCR confirmed COVID-19 positive patients. Results: The group of parameters showing a poor prognosis include a rising WBC count, high neutrophilic percentage, low lymphocyte percentage (<10) an NLR > 15, low lymphocyte monocyte ratio < 3, rising blood urea nitrogen, serum creatinine levels, and serum electrolyte levels. The liver function tests variation reflecting a poor metabolic activity of the liver, namely, a low serum albumin and albumin globulin ratio, rising SGOT levels, and total bilirubin levels. A highly significant variation in the acute phase reactants showing an exponential rise such as the serum lactate dehydrogenase levels, serum ferritin, fibrinogen, C-reactive protein, and IL 6 levels an increased level of D Dimer (>3) and a prolongation of the APTT. Conclusion: The variation of the laboratory parameters acts as a fair marker for the disease progression. Since the disease shows a variable progression with a sudden worsening of the clinical symptoms, a comprehensive monitoring of the laboratory parameters serves to diagnose and treat the disease progression.Anjali Goyal Chandni Gadara Heta Patel Misha Antani Nilay Suthar Manipal College of Medical Sciences, Pokharaarticlecovid-19laboratory parameterscomparisonMedicineRENAsian Journal of Medical Sciences, Vol 12, Iss 12, Pp 9-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 laboratory parameters comparison Medicine R
spellingShingle	covid-19 laboratory parameters comparison Medicine R Anjali Goyal Chandni Gadara Heta Patel Misha Antani Nilay Suthar Trends of variation of the laboratory parameters during the course of COVID-19 Illness
description	Background: The coronavirus pandemic which had its origin in the Wuhan China has been spreading across the globe with far reaching complications and a variable clinical course. A variation of the laboratory parameters during the disease course remains a constant parameter to monitor the disease course and progression. Since the laboratory parameters are standardized globally, these may also act as uniform guidelines for the patients monitoring and treatment. Aims and Objectives: The aim of the study was to serial charting of the laboratory parameters in the recovered and expired patients of COVID-19 and to determine an associated prognostic significance. Materials and Methods: A retrospective observational study from the laboratory and medical records was conducted on the patients admitted from March 17, 2020, to May 31, 2020, at the tertiary care center dedicated to the treatment of RT-PCR confirmed COVID-19 positive patients. Results: The group of parameters showing a poor prognosis include a rising WBC count, high neutrophilic percentage, low lymphocyte percentage (<10) an NLR > 15, low lymphocyte monocyte ratio < 3, rising blood urea nitrogen, serum creatinine levels, and serum electrolyte levels. The liver function tests variation reflecting a poor metabolic activity of the liver, namely, a low serum albumin and albumin globulin ratio, rising SGOT levels, and total bilirubin levels. A highly significant variation in the acute phase reactants showing an exponential rise such as the serum lactate dehydrogenase levels, serum ferritin, fibrinogen, C-reactive protein, and IL 6 levels an increased level of D Dimer (>3) and a prolongation of the APTT. Conclusion: The variation of the laboratory parameters acts as a fair marker for the disease progression. Since the disease shows a variable progression with a sudden worsening of the clinical symptoms, a comprehensive monitoring of the laboratory parameters serves to diagnose and treat the disease progression.
format	article
author	Anjali Goyal Chandni Gadara Heta Patel Misha Antani Nilay Suthar
author_facet	Anjali Goyal Chandni Gadara Heta Patel Misha Antani Nilay Suthar
author_sort	Anjali Goyal
title	Trends of variation of the laboratory parameters during the course of COVID-19 Illness
title_short	Trends of variation of the laboratory parameters during the course of COVID-19 Illness
title_full	Trends of variation of the laboratory parameters during the course of COVID-19 Illness
title_fullStr	Trends of variation of the laboratory parameters during the course of COVID-19 Illness
title_full_unstemmed	Trends of variation of the laboratory parameters during the course of COVID-19 Illness
title_sort	trends of variation of the laboratory parameters during the course of covid-19 illness
publisher	Manipal College of Medical Sciences, Pokhara
publishDate	2021
url	https://doi.org/10.3126/ajms.v12i12.39185 https://doaj.org/article/db3085e14a6343aab9f486b7c4e0f55c
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Trends of variation of the laboratory parameters during the course of COVID-19 Illness

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