Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103

Abstract Microbial endocrinology has demonstrated for more than two decades, that eukaryotic substances (hormones, neurotransmitters, molecules of the immune system) can modulate the physiological behavior of bacteria. Among them, the hormones/neurotransmitters, epinephrine (Epi) and norepinephrine...

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Autores principales:	Mélyssa Cambronel, Damien Tortuel, Kelly Biaggini, Olivier Maillot, Laure Taupin, Karine Réhel, Isabelle Rincé, Cécile Muller, Julie Hardouin, Marc Feuilloley, Sophie Rodrigues, Nathalie Connil
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/db30d62138d14c98a559e4742fa73b6e
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spelling	oai:doaj.org-article:db30d62138d14c98a559e4742fa73b6e2021-12-02T13:57:00ZEpinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H10310.1038/s41598-019-56666-72045-2322https://doaj.org/article/db30d62138d14c98a559e4742fa73b6e2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56666-7https://doaj.org/toc/2045-2322Abstract Microbial endocrinology has demonstrated for more than two decades, that eukaryotic substances (hormones, neurotransmitters, molecules of the immune system) can modulate the physiological behavior of bacteria. Among them, the hormones/neurotransmitters, epinephrine (Epi) and norepinephrine (NE), released in case of stress, physical effort or used in medical treatment, were shown to be able to modify biofilm formation in various bacterial species. In the present study, we have evaluated the effect of Epi on motility, adhesion, biofilm formation and virulence of Pseudomonas aeruginosa, a bacterium linked to many hospital-acquired infections, and responsible for chronic infection in immunocompromised patients including persons suffering from cystic fibrosis. The results showed that Epi increased adhesion and biofilm formation of P. aeruginosa, as well as its virulence towards the Galleria mellonella larvae in vivo model. Deciphering the sensor of this molecule in P. aeruginosa and the molecular mechanisms involved may help to find new strategies of treatment to fight against this bacterium.Mélyssa CambronelDamien TortuelKelly BiagginiOlivier MaillotLaure TaupinKarine RéhelIsabelle RincéCécile MullerJulie HardouinMarc FeuilloleySophie RodriguesNathalie ConnilNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mélyssa Cambronel Damien Tortuel Kelly Biaggini Olivier Maillot Laure Taupin Karine Réhel Isabelle Rincé Cécile Muller Julie Hardouin Marc Feuilloley Sophie Rodrigues Nathalie Connil Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103
description	Abstract Microbial endocrinology has demonstrated for more than two decades, that eukaryotic substances (hormones, neurotransmitters, molecules of the immune system) can modulate the physiological behavior of bacteria. Among them, the hormones/neurotransmitters, epinephrine (Epi) and norepinephrine (NE), released in case of stress, physical effort or used in medical treatment, were shown to be able to modify biofilm formation in various bacterial species. In the present study, we have evaluated the effect of Epi on motility, adhesion, biofilm formation and virulence of Pseudomonas aeruginosa, a bacterium linked to many hospital-acquired infections, and responsible for chronic infection in immunocompromised patients including persons suffering from cystic fibrosis. The results showed that Epi increased adhesion and biofilm formation of P. aeruginosa, as well as its virulence towards the Galleria mellonella larvae in vivo model. Deciphering the sensor of this molecule in P. aeruginosa and the molecular mechanisms involved may help to find new strategies of treatment to fight against this bacterium.
format	article
author	Mélyssa Cambronel Damien Tortuel Kelly Biaggini Olivier Maillot Laure Taupin Karine Réhel Isabelle Rincé Cécile Muller Julie Hardouin Marc Feuilloley Sophie Rodrigues Nathalie Connil
author_facet	Mélyssa Cambronel Damien Tortuel Kelly Biaggini Olivier Maillot Laure Taupin Karine Réhel Isabelle Rincé Cécile Muller Julie Hardouin Marc Feuilloley Sophie Rodrigues Nathalie Connil
author_sort	Mélyssa Cambronel
title	Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103
title_short	Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103
title_full	Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103
title_fullStr	Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103
title_full_unstemmed	Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103
title_sort	epinephrine affects motility, and increases adhesion, biofilm and virulence of pseudomonas aeruginosa h103
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/db30d62138d14c98a559e4742fa73b6e
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Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103

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