Association between CYP2C19 polymorphisms and clinical outcomes in patients undergoing stent procedure for cerebral artery stenosis

Abstract We investigated the effect of CYP2C19 polymorphisms on the clinical outcomes of clopidogrel therapy in patients after stenting procedure for cerebral artery stenosis in northeast China. 568 patients performed CYP2C19 genotype screening in the neurosurgery department of our hospital; 154 pat...

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Autores principales:	Yan-Jiao Li, Xuan Chen, Li-Na Tao, Xin-Yuan Hu, Xin-Lu Wang, Yan-Qing Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/db32ce71b5d744f5a3bf8d068bd49bbb
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spelling	oai:doaj.org-article:db32ce71b5d744f5a3bf8d068bd49bbb2021-12-02T17:04:59ZAssociation between CYP2C19 polymorphisms and clinical outcomes in patients undergoing stent procedure for cerebral artery stenosis10.1038/s41598-021-85580-02045-2322https://doaj.org/article/db32ce71b5d744f5a3bf8d068bd49bbb2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85580-0https://doaj.org/toc/2045-2322Abstract We investigated the effect of CYP2C19 polymorphisms on the clinical outcomes of clopidogrel therapy in patients after stenting procedure for cerebral artery stenosis in northeast China. 568 patients performed CYP2C19 genotype screening in the neurosurgery department of our hospital; 154 patients were finally recruited according to the inclusion and exclusion criteria, and followed-up for 6 months. Ischemic events including (1) transient ischemic attack (TIA); (2) stent thrombosis; (3) ischemic stroke; and (4) death were defined as primary clinical endpoints. The frequencies of CYP2C191, 2 and 3 alleles in 568 patients were 63.1%, 31.1% and 5.8%, respectively. 154 patients were classified into extensive (65 patients; 42.2%), intermediate (66 patients; 42.9%), and poor (23 patients; 14.9%) metabolizer groups. A χ2 test showed a significant difference in primary clinical endpoints at 6 months (P = 0.04), and a multivariate Cox regression analysis indicated that the CYP2C19 loss-of-function (LOF) alleles associated with post-procedure prognosis. The Kaplan–Meier curve revealed that there was no significant difference in ischemic events between 2 and 3 alleles carriers. Our study verifies that CYP2C19 2 and *3 have significant impact on the clinical outcomes of clopidogrel therapy in patients with stenting procedure for cerebral artery stenosis in China.Yan-Jiao LiXuan ChenLi-Na TaoXin-Yuan HuXin-Lu WangYan-Qing SongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan-Jiao Li Xuan Chen Li-Na Tao Xin-Yuan Hu Xin-Lu Wang Yan-Qing Song Association between CYP2C19 polymorphisms and clinical outcomes in patients undergoing stent procedure for cerebral artery stenosis
description	Abstract We investigated the effect of CYP2C19 polymorphisms on the clinical outcomes of clopidogrel therapy in patients after stenting procedure for cerebral artery stenosis in northeast China. 568 patients performed CYP2C19 genotype screening in the neurosurgery department of our hospital; 154 patients were finally recruited according to the inclusion and exclusion criteria, and followed-up for 6 months. Ischemic events including (1) transient ischemic attack (TIA); (2) stent thrombosis; (3) ischemic stroke; and (4) death were defined as primary clinical endpoints. The frequencies of CYP2C191, 2 and 3 alleles in 568 patients were 63.1%, 31.1% and 5.8%, respectively. 154 patients were classified into extensive (65 patients; 42.2%), intermediate (66 patients; 42.9%), and poor (23 patients; 14.9%) metabolizer groups. A χ2 test showed a significant difference in primary clinical endpoints at 6 months (P = 0.04), and a multivariate Cox regression analysis indicated that the CYP2C19 loss-of-function (LOF) alleles associated with post-procedure prognosis. The Kaplan–Meier curve revealed that there was no significant difference in ischemic events between 2 and 3 alleles carriers. Our study verifies that CYP2C19 2 and *3 have significant impact on the clinical outcomes of clopidogrel therapy in patients with stenting procedure for cerebral artery stenosis in China.
format	article
author	Yan-Jiao Li Xuan Chen Li-Na Tao Xin-Yuan Hu Xin-Lu Wang Yan-Qing Song
author_facet	Yan-Jiao Li Xuan Chen Li-Na Tao Xin-Yuan Hu Xin-Lu Wang Yan-Qing Song
author_sort	Yan-Jiao Li
title	Association between CYP2C19 polymorphisms and clinical outcomes in patients undergoing stent procedure for cerebral artery stenosis
title_short	Association between CYP2C19 polymorphisms and clinical outcomes in patients undergoing stent procedure for cerebral artery stenosis
title_full	Association between CYP2C19 polymorphisms and clinical outcomes in patients undergoing stent procedure for cerebral artery stenosis
title_fullStr	Association between CYP2C19 polymorphisms and clinical outcomes in patients undergoing stent procedure for cerebral artery stenosis
title_full_unstemmed	Association between CYP2C19 polymorphisms and clinical outcomes in patients undergoing stent procedure for cerebral artery stenosis
title_sort	association between cyp2c19 polymorphisms and clinical outcomes in patients undergoing stent procedure for cerebral artery stenosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db32ce71b5d744f5a3bf8d068bd49bbb
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Association between CYP2C19 polymorphisms and clinical outcomes in patients undergoing stent procedure for cerebral artery stenosis

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