Plasma Membrane Lipids: An Important Binding Site for All Lipoprotein Classes

Cholesterol is one of the main constituents of plasma membranes; thus, its supply is of utmost importance. This review covers the known mechanisms of cholesterol transfer from circulating lipoprotein particles to the plasma membrane, and vice versa. To achieve homeostasis, the human body utilizes ce...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Markus Axmann, Birgit Plochberger, Mario Mikula, Florian Weber, Witta Monika Strobl, Herbert Stangl
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	non-esterified cholesterol plasma membrane lipoprotein particles HDL LDL Chemical technology TP1-1185 Chemical engineering TP155-156
Acceso en línea:	https://doaj.org/article/db336cda79b445d08cc3975682c81671
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:db336cda79b445d08cc3975682c81671
record_format	dspace
spelling	oai:doaj.org-article:db336cda79b445d08cc3975682c816712021-11-25T18:20:02ZPlasma Membrane Lipids: An Important Binding Site for All Lipoprotein Classes10.3390/membranes111108822077-0375https://doaj.org/article/db336cda79b445d08cc3975682c816712021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0375/11/11/882https://doaj.org/toc/2077-0375Cholesterol is one of the main constituents of plasma membranes; thus, its supply is of utmost importance. This review covers the known mechanisms of cholesterol transfer from circulating lipoprotein particles to the plasma membrane, and vice versa. To achieve homeostasis, the human body utilizes cellular de novo synthesis and extracellular transport particles for supply of cholesterol and other lipids via the blood stream. These lipoprotein particles can be classified according to their density: chylomicrons, very low, low, and high-density lipoprotein (VLDL, LDL, and HDL, respectively). They deliver and receive their lipid loads, most importantly cholesterol, to and from cells by several redundant routes. Defects in one of these pathways (e.g., due to mutations in receptors) usually are not immediately fatal. Several redundant pathways, at least temporarily, compensate for the loss of one or more of them, but the defects trigger systemic diseases, such as atherosclerosis later on. Recently, intracellular membrane–membrane contact sites were shown to be involved in intracellular cholesterol transfer and the plasma membrane itself has been proposed to act as a binding site for lipoprotein-mediated cargo unloading.Markus AxmannBirgit PlochbergerMario MikulaFlorian WeberWitta Monika StroblHerbert StanglMDPI AGarticlenon-esterified cholesterolplasma membranelipoprotein particlesHDLLDLChemical technologyTP1-1185Chemical engineeringTP155-156ENMembranes, Vol 11, Iss 882, p 882 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-esterified cholesterol plasma membrane lipoprotein particles HDL LDL Chemical technology TP1-1185 Chemical engineering TP155-156
spellingShingle	non-esterified cholesterol plasma membrane lipoprotein particles HDL LDL Chemical technology TP1-1185 Chemical engineering TP155-156 Markus Axmann Birgit Plochberger Mario Mikula Florian Weber Witta Monika Strobl Herbert Stangl Plasma Membrane Lipids: An Important Binding Site for All Lipoprotein Classes
description	Cholesterol is one of the main constituents of plasma membranes; thus, its supply is of utmost importance. This review covers the known mechanisms of cholesterol transfer from circulating lipoprotein particles to the plasma membrane, and vice versa. To achieve homeostasis, the human body utilizes cellular de novo synthesis and extracellular transport particles for supply of cholesterol and other lipids via the blood stream. These lipoprotein particles can be classified according to their density: chylomicrons, very low, low, and high-density lipoprotein (VLDL, LDL, and HDL, respectively). They deliver and receive their lipid loads, most importantly cholesterol, to and from cells by several redundant routes. Defects in one of these pathways (e.g., due to mutations in receptors) usually are not immediately fatal. Several redundant pathways, at least temporarily, compensate for the loss of one or more of them, but the defects trigger systemic diseases, such as atherosclerosis later on. Recently, intracellular membrane–membrane contact sites were shown to be involved in intracellular cholesterol transfer and the plasma membrane itself has been proposed to act as a binding site for lipoprotein-mediated cargo unloading.
format	article
author	Markus Axmann Birgit Plochberger Mario Mikula Florian Weber Witta Monika Strobl Herbert Stangl
author_facet	Markus Axmann Birgit Plochberger Mario Mikula Florian Weber Witta Monika Strobl Herbert Stangl
author_sort	Markus Axmann
title	Plasma Membrane Lipids: An Important Binding Site for All Lipoprotein Classes
title_short	Plasma Membrane Lipids: An Important Binding Site for All Lipoprotein Classes
title_full	Plasma Membrane Lipids: An Important Binding Site for All Lipoprotein Classes
title_fullStr	Plasma Membrane Lipids: An Important Binding Site for All Lipoprotein Classes
title_full_unstemmed	Plasma Membrane Lipids: An Important Binding Site for All Lipoprotein Classes
title_sort	plasma membrane lipids: an important binding site for all lipoprotein classes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/db336cda79b445d08cc3975682c81671
work_keys_str_mv	AT markusaxmann plasmamembranelipidsanimportantbindingsiteforalllipoproteinclasses AT birgitplochberger plasmamembranelipidsanimportantbindingsiteforalllipoproteinclasses AT mariomikula plasmamembranelipidsanimportantbindingsiteforalllipoproteinclasses AT florianweber plasmamembranelipidsanimportantbindingsiteforalllipoproteinclasses AT wittamonikastrobl plasmamembranelipidsanimportantbindingsiteforalllipoproteinclasses AT herbertstangl plasmamembranelipidsanimportantbindingsiteforalllipoproteinclasses
_version_	1718411350510665728

Plasma Membrane Lipids: An Important Binding Site for All Lipoprotein Classes

Ejemplares similares