Receptor-Mediated NETosis on Neutrophils

Neutrophil extracellular traps (NETs), a web-like structures containing chromatin, have a significant role in assisting the capture and killing of microorganisms by neutrophils during infection. The specific engagement of cell-surface receptors by extracellular signaling molecules activates diverse...

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Autores principales:	Tao Chen, Yanhong Li, Rui Sun, Huifang Hu, Yi Liu, Martin Herrmann, Yi Zhao, Luis E. Muñoz
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	neutrophil extracellular traps chemokine receptor Fc receptors complement receptors pattern recognition receptors Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/db34600089a94c1396c0cfeba6fb55c2
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spelling	oai:doaj.org-article:db34600089a94c1396c0cfeba6fb55c22021-11-04T07:22:04ZReceptor-Mediated NETosis on Neutrophils1664-322410.3389/fimmu.2021.775267https://doaj.org/article/db34600089a94c1396c0cfeba6fb55c22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.775267/fullhttps://doaj.org/toc/1664-3224Neutrophil extracellular traps (NETs), a web-like structures containing chromatin, have a significant role in assisting the capture and killing of microorganisms by neutrophils during infection. The specific engagement of cell-surface receptors by extracellular signaling molecules activates diverse intracellular signaling cascades and regulates neutrophil effector functions, including phagocytosis, reactive oxygen species release, degranulation, and NET formation. However, overproduction of NETs is closely related to the occurrence of inflammation, autoimmune disorders, non-canonical thrombosis and tumor metastasis. Therefore, it is necessary to understand neutrophil activation signals and the subsequent formation of NETs, as well as the related immune regulation. In this review, we provide an overview of the immunoreceptor-mediated regulation of NETosis. The pathways involved in the release of NETs during infection or stimulation by noninfectious substances are discussed in detail. The mechanisms by which neutrophils undergo NETosis help to refine our views on the roles of NETs in immune protection and autoimmune diseases, providing a theoretical basis for research on the immune regulation of NETs.Tao ChenTao ChenTao ChenYanhong LiYanhong LiYanhong LiRui SunRui SunRui SunHuifang HuHuifang HuHuifang HuYi LiuYi LiuYi LiuMartin HerrmannYi ZhaoYi ZhaoYi ZhaoLuis E. MuñozFrontiers Media S.A.articleneutrophil extracellular trapschemokine receptorFc receptorscomplement receptorspattern recognition receptorsImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neutrophil extracellular traps chemokine receptor Fc receptors complement receptors pattern recognition receptors Immunologic diseases. Allergy RC581-607
spellingShingle	neutrophil extracellular traps chemokine receptor Fc receptors complement receptors pattern recognition receptors Immunologic diseases. Allergy RC581-607 Tao Chen Tao Chen Tao Chen Yanhong Li Yanhong Li Yanhong Li Rui Sun Rui Sun Rui Sun Huifang Hu Huifang Hu Huifang Hu Yi Liu Yi Liu Yi Liu Martin Herrmann Yi Zhao Yi Zhao Yi Zhao Luis E. Muñoz Receptor-Mediated NETosis on Neutrophils
description	Neutrophil extracellular traps (NETs), a web-like structures containing chromatin, have a significant role in assisting the capture and killing of microorganisms by neutrophils during infection. The specific engagement of cell-surface receptors by extracellular signaling molecules activates diverse intracellular signaling cascades and regulates neutrophil effector functions, including phagocytosis, reactive oxygen species release, degranulation, and NET formation. However, overproduction of NETs is closely related to the occurrence of inflammation, autoimmune disorders, non-canonical thrombosis and tumor metastasis. Therefore, it is necessary to understand neutrophil activation signals and the subsequent formation of NETs, as well as the related immune regulation. In this review, we provide an overview of the immunoreceptor-mediated regulation of NETosis. The pathways involved in the release of NETs during infection or stimulation by noninfectious substances are discussed in detail. The mechanisms by which neutrophils undergo NETosis help to refine our views on the roles of NETs in immune protection and autoimmune diseases, providing a theoretical basis for research on the immune regulation of NETs.
format	article
author	Tao Chen Tao Chen Tao Chen Yanhong Li Yanhong Li Yanhong Li Rui Sun Rui Sun Rui Sun Huifang Hu Huifang Hu Huifang Hu Yi Liu Yi Liu Yi Liu Martin Herrmann Yi Zhao Yi Zhao Yi Zhao Luis E. Muñoz
author_facet	Tao Chen Tao Chen Tao Chen Yanhong Li Yanhong Li Yanhong Li Rui Sun Rui Sun Rui Sun Huifang Hu Huifang Hu Huifang Hu Yi Liu Yi Liu Yi Liu Martin Herrmann Yi Zhao Yi Zhao Yi Zhao Luis E. Muñoz
author_sort	Tao Chen
title	Receptor-Mediated NETosis on Neutrophils
title_short	Receptor-Mediated NETosis on Neutrophils
title_full	Receptor-Mediated NETosis on Neutrophils
title_fullStr	Receptor-Mediated NETosis on Neutrophils
title_full_unstemmed	Receptor-Mediated NETosis on Neutrophils
title_sort	receptor-mediated netosis on neutrophils
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/db34600089a94c1396c0cfeba6fb55c2
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Receptor-Mediated NETosis on Neutrophils

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