Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

New vessel formation relies on a tightly controlled switch in endothelial biology from proliferating to specializing phenotypes. Here, Fang et al. elucidate the molecular mechanisms of this switch and show that the arterial shear activates a Notch-Cx37-p27 axis promoting endothelial cell cycle arre...

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Autores principales:	Jennifer S. Fang, Brian G. Coon, Noelle Gillis, Zehua Chen, Jingyao Qiu, Thomas W. Chittenden, Janis M. Burt, Martin A. Schwartz, Karen K. Hirschi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db347af2168d4593b642250c5c0ab8aa
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spelling	oai:doaj.org-article:db347af2168d4593b642250c5c0ab8aa2021-12-02T15:38:45ZShear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification10.1038/s41467-017-01742-72041-1723https://doaj.org/article/db347af2168d4593b642250c5c0ab8aa2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01742-7https://doaj.org/toc/2041-1723New vessel formation relies on a tightly controlled switch in endothelial biology from proliferating to specializing phenotypes. Here, Fang et al. elucidate the molecular mechanisms of this switch and show that the arterial shear activates a Notch-Cx37-p27 axis promoting endothelial cell cycle arrest and enabling arterial gene expression.Jennifer S. FangBrian G. CoonNoelle GillisZehua ChenJingyao QiuThomas W. ChittendenJanis M. BurtMartin A. SchwartzKaren K. HirschiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer S. Fang Brian G. Coon Noelle Gillis Zehua Chen Jingyao Qiu Thomas W. Chittenden Janis M. Burt Martin A. Schwartz Karen K. Hirschi Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
description	New vessel formation relies on a tightly controlled switch in endothelial biology from proliferating to specializing phenotypes. Here, Fang et al. elucidate the molecular mechanisms of this switch and show that the arterial shear activates a Notch-Cx37-p27 axis promoting endothelial cell cycle arrest and enabling arterial gene expression.
format	article
author	Jennifer S. Fang Brian G. Coon Noelle Gillis Zehua Chen Jingyao Qiu Thomas W. Chittenden Janis M. Burt Martin A. Schwartz Karen K. Hirschi
author_facet	Jennifer S. Fang Brian G. Coon Noelle Gillis Zehua Chen Jingyao Qiu Thomas W. Chittenden Janis M. Burt Martin A. Schwartz Karen K. Hirschi
author_sort	Jennifer S. Fang
title	Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
title_short	Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
title_full	Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
title_fullStr	Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
title_full_unstemmed	Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
title_sort	shear-induced notch-cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/db347af2168d4593b642250c5c0ab8aa
work_keys_str_mv	AT jennifersfang shearinducednotchcx37p27axisarrestsendothelialcellcycletoenablearterialspecification AT briangcoon shearinducednotchcx37p27axisarrestsendothelialcellcycletoenablearterialspecification AT noellegillis shearinducednotchcx37p27axisarrestsendothelialcellcycletoenablearterialspecification AT zehuachen shearinducednotchcx37p27axisarrestsendothelialcellcycletoenablearterialspecification AT jingyaoqiu shearinducednotchcx37p27axisarrestsendothelialcellcycletoenablearterialspecification AT thomaswchittenden shearinducednotchcx37p27axisarrestsendothelialcellcycletoenablearterialspecification AT janismburt shearinducednotchcx37p27axisarrestsendothelialcellcycletoenablearterialspecification AT martinaschwartz shearinducednotchcx37p27axisarrestsendothelialcellcycletoenablearterialspecification AT karenkhirschi shearinducednotchcx37p27axisarrestsendothelialcellcycletoenablearterialspecification
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Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

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