Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis

Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis

Mass spectrometry facilitates large-scale glycosylation profiling but in-depth analysis of intact glycopeptides is still challenging. Here, the authors show that activated ion electron transfer dissociation is suitable for glycopeptide fragmentation and improves glycoproteome coverage.

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Autores principales: Nicholas M. Riley, Alexander S. Hebert, Michael S. Westphall, Joshua J. Coon
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/db34920cf377464b93976745b85dbd71
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spelling oai:doaj.org-article:db34920cf377464b93976745b85dbd712021-12-02T14:38:42ZCapturing site-specific heterogeneity with large-scale N-glycoproteome analysis10.1038/s41467-019-09222-w2041-1723https://doaj.org/article/db34920cf377464b93976745b85dbd712019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09222-whttps://doaj.org/toc/2041-1723Mass spectrometry facilitates large-scale glycosylation profiling but in-depth analysis of intact glycopeptides is still challenging. Here, the authors show that activated ion electron transfer dissociation is suitable for glycopeptide fragmentation and improves glycoproteome coverage.Nicholas M. RileyAlexander S. HebertMichael S. WestphallJoshua J. CoonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nicholas M. Riley
Alexander S. Hebert
Michael S. Westphall
Joshua J. Coon
Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis
description Mass spectrometry facilitates large-scale glycosylation profiling but in-depth analysis of intact glycopeptides is still challenging. Here, the authors show that activated ion electron transfer dissociation is suitable for glycopeptide fragmentation and improves glycoproteome coverage.
format article
author Nicholas M. Riley
Alexander S. Hebert
Michael S. Westphall
Joshua J. Coon
author_facet Nicholas M. Riley
Alexander S. Hebert
Michael S. Westphall
Joshua J. Coon
author_sort Nicholas M. Riley
title Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis
title_short Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis
title_full Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis
title_fullStr Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis
title_full_unstemmed Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis
title_sort capturing site-specific heterogeneity with large-scale n-glycoproteome analysis
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/db34920cf377464b93976745b85dbd71
work_keys_str_mv AT nicholasmriley capturingsitespecificheterogeneitywithlargescalenglycoproteomeanalysis
AT alexandershebert capturingsitespecificheterogeneitywithlargescalenglycoproteomeanalysis
AT michaelswestphall capturingsitespecificheterogeneitywithlargescalenglycoproteomeanalysis
AT joshuajcoon capturingsitespecificheterogeneitywithlargescalenglycoproteomeanalysis
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