It Cuts Both Ways: An Annelid Model System for the Study of Regeneration in the Laboratory and in the Classroom

The mechanisms supporting regeneration and successful recovery of function have fascinated scientists and the general public for quite some time, with the earliest description of regeneration occurring in the 8th century BC through the Greek mythological story of Prometheus. While most animals demon...

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Autores principales:	Veronica G. Martinez Acosta, Fausto Arellano-Carbajal, Kathy Gillen, Kay A. Tweeten, Eduardo E. Zattara
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	clitellate molecular resources stem cells neurophysiology invertebrate biology STEM education Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/db3501c855b849ef914f238214fed1ee
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spelling	oai:doaj.org-article:db3501c855b849ef914f238214fed1ee2021-12-01T13:23:25ZIt Cuts Both Ways: An Annelid Model System for the Study of Regeneration in the Laboratory and in the Classroom2296-634X10.3389/fcell.2021.780422https://doaj.org/article/db3501c855b849ef914f238214fed1ee2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.780422/fullhttps://doaj.org/toc/2296-634XThe mechanisms supporting regeneration and successful recovery of function have fascinated scientists and the general public for quite some time, with the earliest description of regeneration occurring in the 8th century BC through the Greek mythological story of Prometheus. While most animals demonstrate the capacity for wound-healing, the ability to initiate a developmental process that leads to a partial or complete replacement of a lost structure varies widely among animal taxa. Variation also occurs within single species based on the nature and location of the wound and the developmental stage or age of the individual. Comparative studies of cellular and molecular changes that occur both during, and following, wound healing may point to conserved genomic pathways among animals of different regenerative capacity. Such insights could revolutionize studies within the field of regenerative medicine. In this review, we focus on several closely related species of Lumbriculus (Clitellata: Lumbriculidae), as we present a case for revisiting the use of an annelid model system for the study of regeneration. We hope that this review will provide a primer to Lumbriculus biology not only for regeneration researchers but also for STEM teachers and their students.Veronica G. Martinez AcostaFausto Arellano-CarbajalKathy GillenKay A. TweetenEduardo E. ZattaraEduardo E. ZattaraEduardo E. ZattaraFrontiers Media S.A.articleclitellatemolecular resourcesstem cellsneurophysiologyinvertebrate biologySTEM educationBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clitellate molecular resources stem cells neurophysiology invertebrate biology STEM education Biology (General) QH301-705.5
spellingShingle	clitellate molecular resources stem cells neurophysiology invertebrate biology STEM education Biology (General) QH301-705.5 Veronica G. Martinez Acosta Fausto Arellano-Carbajal Kathy Gillen Kay A. Tweeten Eduardo E. Zattara Eduardo E. Zattara Eduardo E. Zattara It Cuts Both Ways: An Annelid Model System for the Study of Regeneration in the Laboratory and in the Classroom
description	The mechanisms supporting regeneration and successful recovery of function have fascinated scientists and the general public for quite some time, with the earliest description of regeneration occurring in the 8th century BC through the Greek mythological story of Prometheus. While most animals demonstrate the capacity for wound-healing, the ability to initiate a developmental process that leads to a partial or complete replacement of a lost structure varies widely among animal taxa. Variation also occurs within single species based on the nature and location of the wound and the developmental stage or age of the individual. Comparative studies of cellular and molecular changes that occur both during, and following, wound healing may point to conserved genomic pathways among animals of different regenerative capacity. Such insights could revolutionize studies within the field of regenerative medicine. In this review, we focus on several closely related species of Lumbriculus (Clitellata: Lumbriculidae), as we present a case for revisiting the use of an annelid model system for the study of regeneration. We hope that this review will provide a primer to Lumbriculus biology not only for regeneration researchers but also for STEM teachers and their students.
format	article
author	Veronica G. Martinez Acosta Fausto Arellano-Carbajal Kathy Gillen Kay A. Tweeten Eduardo E. Zattara Eduardo E. Zattara Eduardo E. Zattara
author_facet	Veronica G. Martinez Acosta Fausto Arellano-Carbajal Kathy Gillen Kay A. Tweeten Eduardo E. Zattara Eduardo E. Zattara Eduardo E. Zattara
author_sort	Veronica G. Martinez Acosta
title	It Cuts Both Ways: An Annelid Model System for the Study of Regeneration in the Laboratory and in the Classroom
title_short	It Cuts Both Ways: An Annelid Model System for the Study of Regeneration in the Laboratory and in the Classroom
title_full	It Cuts Both Ways: An Annelid Model System for the Study of Regeneration in the Laboratory and in the Classroom
title_fullStr	It Cuts Both Ways: An Annelid Model System for the Study of Regeneration in the Laboratory and in the Classroom
title_full_unstemmed	It Cuts Both Ways: An Annelid Model System for the Study of Regeneration in the Laboratory and in the Classroom
title_sort	it cuts both ways: an annelid model system for the study of regeneration in the laboratory and in the classroom
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/db3501c855b849ef914f238214fed1ee
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It Cuts Both Ways: An Annelid Model System for the Study of Regeneration in the Laboratory and in the Classroom

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