Discovery of tumor immune infiltration-related snoRNAs for predicting tumor immune microenvironment status and prognosis in lung adenocarcinoma

Lung adenocarcinoma (LUAD) has a high mortality rate and is difficult to diagnose and treat in its early stage. Previous studies have demonstrated that small nucleolar RNAs (snoRNAs) play a critical role in tumor immune infiltration and the development of a variety of solid tumors. However, there ha...

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Autores principales:	Rongjun Wan, Lu Bai, Changjing Cai, Wang Ya, Juan Jiang, Chengping Hu, Qiong Chen, Bingrong Zhao, Yuanyuan Li
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Small nucleolar RNAs Lung adenocarcinoma Tumor cell immune infiltration TIISR signature Immune checkpoints Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/db35a153aca74ffbbb2437c2c174395a
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spelling	oai:doaj.org-article:db35a153aca74ffbbb2437c2c174395a2021-12-04T04:33:34ZDiscovery of tumor immune infiltration-related snoRNAs for predicting tumor immune microenvironment status and prognosis in lung adenocarcinoma2001-037010.1016/j.csbj.2021.11.032https://doaj.org/article/db35a153aca74ffbbb2437c2c174395a2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2001037021004979https://doaj.org/toc/2001-0370Lung adenocarcinoma (LUAD) has a high mortality rate and is difficult to diagnose and treat in its early stage. Previous studies have demonstrated that small nucleolar RNAs (snoRNAs) play a critical role in tumor immune infiltration and the development of a variety of solid tumors. However, there have been no studies on the correlation between tumor-infiltrating immune-related snoRNAs (TIISRs) and LUAD.In this study, we filtered six immune-related snoRNAs based on the tissue specificity index (TSI) and expression profile of all snoRNAs between all LUAD cell lines from the Cancer Cell Line Encyclopedia and 21 types of immune cells from the Gene Expression Omnibus database. Further, we performed real-time quantitative polymerase chain reaction (RT-qPCR) to validate the expression status of these snoRNAs on peripheral blood mononuclear cells (PBMCs) and lung cancer cell lines. Next, we developed a TIISR signature based on the expression profiles of snoRNAs from 479 LUAD patients filtered by the random survival forest algorithm. We then analyzed the value of this TIISR signature (TIISR risk score) for assessing tumor immune infiltration, immune checkpoint inhibitor (ICI) treatment response, and the prognosis of LUAD between groups with high and low TIISR risk score. Further, we found that the TIISR risk score groups showed significant differences in biological characteristics and that the risk score could be used to assess the level of tumor immune cell infiltration, thereby predicting prognosis and responsiveness to immunotherapy in LUAD patients.Rongjun WanLu BaiChangjing CaiWang YaJuan JiangChengping HuQiong ChenBingrong ZhaoYuanyuan LiElsevierarticleSmall nucleolar RNAsLung adenocarcinomaTumor cell immune infiltrationTIISR signatureImmune checkpointsBiotechnologyTP248.13-248.65ENComputational and Structural Biotechnology Journal, Vol 19, Iss , Pp 6386-6399 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Small nucleolar RNAs Lung adenocarcinoma Tumor cell immune infiltration TIISR signature Immune checkpoints Biotechnology TP248.13-248.65
spellingShingle	Small nucleolar RNAs Lung adenocarcinoma Tumor cell immune infiltration TIISR signature Immune checkpoints Biotechnology TP248.13-248.65 Rongjun Wan Lu Bai Changjing Cai Wang Ya Juan Jiang Chengping Hu Qiong Chen Bingrong Zhao Yuanyuan Li Discovery of tumor immune infiltration-related snoRNAs for predicting tumor immune microenvironment status and prognosis in lung adenocarcinoma
description	Lung adenocarcinoma (LUAD) has a high mortality rate and is difficult to diagnose and treat in its early stage. Previous studies have demonstrated that small nucleolar RNAs (snoRNAs) play a critical role in tumor immune infiltration and the development of a variety of solid tumors. However, there have been no studies on the correlation between tumor-infiltrating immune-related snoRNAs (TIISRs) and LUAD.In this study, we filtered six immune-related snoRNAs based on the tissue specificity index (TSI) and expression profile of all snoRNAs between all LUAD cell lines from the Cancer Cell Line Encyclopedia and 21 types of immune cells from the Gene Expression Omnibus database. Further, we performed real-time quantitative polymerase chain reaction (RT-qPCR) to validate the expression status of these snoRNAs on peripheral blood mononuclear cells (PBMCs) and lung cancer cell lines. Next, we developed a TIISR signature based on the expression profiles of snoRNAs from 479 LUAD patients filtered by the random survival forest algorithm. We then analyzed the value of this TIISR signature (TIISR risk score) for assessing tumor immune infiltration, immune checkpoint inhibitor (ICI) treatment response, and the prognosis of LUAD between groups with high and low TIISR risk score. Further, we found that the TIISR risk score groups showed significant differences in biological characteristics and that the risk score could be used to assess the level of tumor immune cell infiltration, thereby predicting prognosis and responsiveness to immunotherapy in LUAD patients.
format	article
author	Rongjun Wan Lu Bai Changjing Cai Wang Ya Juan Jiang Chengping Hu Qiong Chen Bingrong Zhao Yuanyuan Li
author_facet	Rongjun Wan Lu Bai Changjing Cai Wang Ya Juan Jiang Chengping Hu Qiong Chen Bingrong Zhao Yuanyuan Li
author_sort	Rongjun Wan
title	Discovery of tumor immune infiltration-related snoRNAs for predicting tumor immune microenvironment status and prognosis in lung adenocarcinoma
title_short	Discovery of tumor immune infiltration-related snoRNAs for predicting tumor immune microenvironment status and prognosis in lung adenocarcinoma
title_full	Discovery of tumor immune infiltration-related snoRNAs for predicting tumor immune microenvironment status and prognosis in lung adenocarcinoma
title_fullStr	Discovery of tumor immune infiltration-related snoRNAs for predicting tumor immune microenvironment status and prognosis in lung adenocarcinoma
title_full_unstemmed	Discovery of tumor immune infiltration-related snoRNAs for predicting tumor immune microenvironment status and prognosis in lung adenocarcinoma
title_sort	discovery of tumor immune infiltration-related snornas for predicting tumor immune microenvironment status and prognosis in lung adenocarcinoma
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/db35a153aca74ffbbb2437c2c174395a
work_keys_str_mv	AT rongjunwan discoveryoftumorimmuneinfiltrationrelatedsnornasforpredictingtumorimmunemicroenvironmentstatusandprognosisinlungadenocarcinoma AT lubai discoveryoftumorimmuneinfiltrationrelatedsnornasforpredictingtumorimmunemicroenvironmentstatusandprognosisinlungadenocarcinoma AT changjingcai discoveryoftumorimmuneinfiltrationrelatedsnornasforpredictingtumorimmunemicroenvironmentstatusandprognosisinlungadenocarcinoma AT wangya discoveryoftumorimmuneinfiltrationrelatedsnornasforpredictingtumorimmunemicroenvironmentstatusandprognosisinlungadenocarcinoma AT juanjiang discoveryoftumorimmuneinfiltrationrelatedsnornasforpredictingtumorimmunemicroenvironmentstatusandprognosisinlungadenocarcinoma AT chengpinghu discoveryoftumorimmuneinfiltrationrelatedsnornasforpredictingtumorimmunemicroenvironmentstatusandprognosisinlungadenocarcinoma AT qiongchen discoveryoftumorimmuneinfiltrationrelatedsnornasforpredictingtumorimmunemicroenvironmentstatusandprognosisinlungadenocarcinoma AT bingrongzhao discoveryoftumorimmuneinfiltrationrelatedsnornasforpredictingtumorimmunemicroenvironmentstatusandprognosisinlungadenocarcinoma AT yuanyuanli discoveryoftumorimmuneinfiltrationrelatedsnornasforpredictingtumorimmunemicroenvironmentstatusandprognosisinlungadenocarcinoma
_version_	1718372998500581376

Discovery of tumor immune infiltration-related snoRNAs for predicting tumor immune microenvironment status and prognosis in lung adenocarcinoma

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