Indexing cerebrovascular health using near-infrared spectroscopy

Abstract Near-infrared spectroscopy (NiRS) is a relatively new technology of brain imaging with its potential in the assessment of cerebrovascular health only recently discovered. Encouraging early results suggest that NiRS can be used as an inexpensive and portable cerebrovascular health tracking d...

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Autores principales:	Rashid Afkhami, Frederick R. Walker, Saadallah Ramadan, Rachel Wong, Sarah J. Johnson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/db36bc42e87545f9808bf4d084745600
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spelling	oai:doaj.org-article:db36bc42e87545f9808bf4d0847456002021-12-02T16:17:21ZIndexing cerebrovascular health using near-infrared spectroscopy10.1038/s41598-021-94348-52045-2322https://doaj.org/article/db36bc42e87545f9808bf4d0847456002021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94348-5https://doaj.org/toc/2045-2322Abstract Near-infrared spectroscopy (NiRS) is a relatively new technology of brain imaging with its potential in the assessment of cerebrovascular health only recently discovered. Encouraging early results suggest that NiRS can be used as an inexpensive and portable cerebrovascular health tracking device using a recently proposed pulse relaxation function (PReFx). In this paper, we propose a new NiRS timing index, $$\text {TI}_{\rm NiRS}$$ TI NiRS , of cerebrovascular health. $$\text {TI}_{\rm NiRS}$$ TI NiRS is a novel use of the NiRS technology. $$\text {TI}_{\rm NiRS}$$ TI NiRS is motivated by the previously proved relationship of the timing of the reflected wave with vascular resistance and compliance in the context of pressure waveforms. We correlated both $$\text {TI}_{\rm NiRS}$$ TI NiRS and PReFx against age, a non-exercise cardiorespiratory fitness (CRF) index, and two existing indices of cerebrovascular health, namely transcranial Doppler (TCD) augmentation index, $$\text {AI}_{\rm TCD}$$ AI TCD , and magnetic resonance imaging (MRI) blood flow pulsatility index, $$\text {PI}_{\rm MRI}$$ PI MRI . The $$\text {TI}_{\rm NiRS}$$ TI NiRS correlations with Age, CRF, $$\text {PI}_{\rm MRI}$$ PI MRI and $$\text {AI}_{\rm TCD}$$ AI TCD all are significant, i.e., $$r=0.53$$ r = 0.53 ( $$p=0.002$$ p = 0.002 ), $$r=-0.44$$ r = - 0.44 ( $$p=0.011$$ p = 0.011 ), $$r=0.45$$ r = 0.45 ( $$p=0.012$$ p = 0.012 ) and $$r=0.46$$ r = 0.46 ( $$p=0.010$$ p = 0.010 ), respectively. PReFx, however, did not have significant correlations with any of the vascular health factors. The proposed timing index is a reliable indicator of cerebrovascular aging factors in the NiRS waveform.Rashid AfkhamiFrederick R. WalkerSaadallah RamadanRachel WongSarah J. JohnsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rashid Afkhami Frederick R. Walker Saadallah Ramadan Rachel Wong Sarah J. Johnson Indexing cerebrovascular health using near-infrared spectroscopy
description	Abstract Near-infrared spectroscopy (NiRS) is a relatively new technology of brain imaging with its potential in the assessment of cerebrovascular health only recently discovered. Encouraging early results suggest that NiRS can be used as an inexpensive and portable cerebrovascular health tracking device using a recently proposed pulse relaxation function (PReFx). In this paper, we propose a new NiRS timing index, $$\text {TI}_{\rm NiRS}$$ TI NiRS , of cerebrovascular health. $$\text {TI}_{\rm NiRS}$$ TI NiRS is a novel use of the NiRS technology. $$\text {TI}_{\rm NiRS}$$ TI NiRS is motivated by the previously proved relationship of the timing of the reflected wave with vascular resistance and compliance in the context of pressure waveforms. We correlated both $$\text {TI}_{\rm NiRS}$$ TI NiRS and PReFx against age, a non-exercise cardiorespiratory fitness (CRF) index, and two existing indices of cerebrovascular health, namely transcranial Doppler (TCD) augmentation index, $$\text {AI}_{\rm TCD}$$ AI TCD , and magnetic resonance imaging (MRI) blood flow pulsatility index, $$\text {PI}_{\rm MRI}$$ PI MRI . The $$\text {TI}_{\rm NiRS}$$ TI NiRS correlations with Age, CRF, $$\text {PI}_{\rm MRI}$$ PI MRI and $$\text {AI}_{\rm TCD}$$ AI TCD all are significant, i.e., $$r=0.53$$ r = 0.53 ( $$p=0.002$$ p = 0.002 ), $$r=-0.44$$ r = - 0.44 ( $$p=0.011$$ p = 0.011 ), $$r=0.45$$ r = 0.45 ( $$p=0.012$$ p = 0.012 ) and $$r=0.46$$ r = 0.46 ( $$p=0.010$$ p = 0.010 ), respectively. PReFx, however, did not have significant correlations with any of the vascular health factors. The proposed timing index is a reliable indicator of cerebrovascular aging factors in the NiRS waveform.
format	article
author	Rashid Afkhami Frederick R. Walker Saadallah Ramadan Rachel Wong Sarah J. Johnson
author_facet	Rashid Afkhami Frederick R. Walker Saadallah Ramadan Rachel Wong Sarah J. Johnson
author_sort	Rashid Afkhami
title	Indexing cerebrovascular health using near-infrared spectroscopy
title_short	Indexing cerebrovascular health using near-infrared spectroscopy
title_full	Indexing cerebrovascular health using near-infrared spectroscopy
title_fullStr	Indexing cerebrovascular health using near-infrared spectroscopy
title_full_unstemmed	Indexing cerebrovascular health using near-infrared spectroscopy
title_sort	indexing cerebrovascular health using near-infrared spectroscopy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db36bc42e87545f9808bf4d084745600
work_keys_str_mv	AT rashidafkhami indexingcerebrovascularhealthusingnearinfraredspectroscopy AT frederickrwalker indexingcerebrovascularhealthusingnearinfraredspectroscopy AT saadallahramadan indexingcerebrovascularhealthusingnearinfraredspectroscopy AT rachelwong indexingcerebrovascularhealthusingnearinfraredspectroscopy AT sarahjjohnson indexingcerebrovascularhealthusingnearinfraredspectroscopy
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Indexing cerebrovascular health using near-infrared spectroscopy

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