Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening

Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening

ABSTRACT Cryptococcus neoformans is a pathogenic fungus that is responsible for up to half a million cases of meningitis globally, especially in immunocompromised individuals. Common fungistatic drugs, such as fluconazole, are less toxic for patients but have low efficacy for initial therapy of the...

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Main Authors: Yoon-Dong Park, Wei Sun, Antonio Salas, Avan Antia, Cindy Carvajal, Amy Wang, Xin Xu, Zhaojin Meng, Ming Zhou, Gregory J. Tawa, Jean Dehdashti, Wei Zheng, Christina M. Henderson, Adrian M. Zelazny, Peter R. Williamson
Format: article
Language:EN
Published: American Society for Microbiology 2016
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/db380ece62464859a07b18fca038063f
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https://doaj.org/article/db380ece62464859a07b18fca038063f

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