Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia

Premysl Vlcek,1 Petr Bob,1,2 Jiri Raboch1 1Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, First Faculty of Medicine, Charles University, Prague, Czech Republic; 2Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republi...

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Autores principales:	Vlcek P, Bob P, Raboch J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/db3c23d5f8104efdb7619d661cf0191d
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spelling	oai:doaj.org-article:db3c23d5f8104efdb7619d661cf0191d2021-12-02T02:26:23ZSensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia1178-2021https://doaj.org/article/db3c23d5f8104efdb7619d661cf0191d2014-07-01T00:00:00Zhttp://www.dovepress.com/sensory-disturbances-inhibitory-deficits-and-the-p50-wave-in-schizophr-a17586https://doaj.org/toc/1178-2021 Premysl Vlcek,1 Petr Bob,1,2 Jiri Raboch1 1Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, First Faculty of Medicine, Charles University, Prague, Czech Republic; 2Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic Abstract: Sensory gating disturbances in schizophrenia are often described as an inability to filter redundant sensory stimuli that typically manifest as inability to gate neuronal responses related to the P50 wave, characterizing a decreased ability of the brain to inhibit various responses to insignificant stimuli. It implicates various deficits of perceptual and attentional functions, and this inability to inhibit, or “gate”, irrelevant sensory inputs leads to sensory and information overload that also may result in neuronal hyperexcitability related to disturbances of habituation mechanisms. These findings seem to be particularly important in the context of modern electrophysiological and neuroimaging data suggesting that the filtering deficits in schizophrenia are likely related to deficits in the integrity of connections between various brain areas. As a consequence, this brain disintegration produces disconnection of information, disrupted binding, and disintegration of consciousness that in terms of modern neuroscience could connect original Bleuler’s concept of “split mind” with research of neural information integration. Keywords: event-related potential, information overload, inhibition, P50 wave, schizophrenia, splittingVlcek PBob PRaboch JDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1309-1315 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Vlcek P Bob P Raboch J Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia
description	Premysl Vlcek,1 Petr Bob,1,2 Jiri Raboch1 1Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, First Faculty of Medicine, Charles University, Prague, Czech Republic; 2Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic Abstract: Sensory gating disturbances in schizophrenia are often described as an inability to filter redundant sensory stimuli that typically manifest as inability to gate neuronal responses related to the P50 wave, characterizing a decreased ability of the brain to inhibit various responses to insignificant stimuli. It implicates various deficits of perceptual and attentional functions, and this inability to inhibit, or “gate”, irrelevant sensory inputs leads to sensory and information overload that also may result in neuronal hyperexcitability related to disturbances of habituation mechanisms. These findings seem to be particularly important in the context of modern electrophysiological and neuroimaging data suggesting that the filtering deficits in schizophrenia are likely related to deficits in the integrity of connections between various brain areas. As a consequence, this brain disintegration produces disconnection of information, disrupted binding, and disintegration of consciousness that in terms of modern neuroscience could connect original Bleuler’s concept of “split mind” with research of neural information integration. Keywords: event-related potential, information overload, inhibition, P50 wave, schizophrenia, splitting
format	article
author	Vlcek P Bob P Raboch J
author_facet	Vlcek P Bob P Raboch J
author_sort	Vlcek P
title	Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia
title_short	Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia
title_full	Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia
title_fullStr	Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia
title_full_unstemmed	Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia
title_sort	sensory disturbances, inhibitory deficits, and the p50 wave in schizophrenia
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/db3c23d5f8104efdb7619d661cf0191d
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_version_	1718402498642837504

Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia

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