Radical Scavenging Actions and Immunomodulatory Activity of <i>Aronia melanocarpa</i> Propylene Glycol Extracts

Researchers are attracted to the wide-ranging, useful components in <i>Aronia melanocarpa</i> berries. They are searching for the most effective ways to extract the active substances that can enhance the body’s protective properties. The current study presents detailed information about...

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Autores principales:	Kseniya Bushmeleva, Alexandra Vyshtakalyuk, Dmitriy Terenzhev, Timur Belov, Andrey Parfenov, Natalia Sharonova, Evgeniy Nikitin, Vladimir Zobov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Aronia melanocarpa</i> black chokeberry bioactive compounds extracts method of preparing raw materials antioxidant capacity Botany QK1-989
Acceso en línea:	https://doaj.org/article/db3d454bbcdb4d8a8fd14047b670467f
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spelling	oai:doaj.org-article:db3d454bbcdb4d8a8fd14047b670467f2021-11-25T18:46:46ZRadical Scavenging Actions and Immunomodulatory Activity of <i>Aronia melanocarpa</i> Propylene Glycol Extracts10.3390/plants101124582223-7747https://doaj.org/article/db3d454bbcdb4d8a8fd14047b670467f2021-11-01T00:00:00Zhttps://www.mdpi.com/2223-7747/10/11/2458https://doaj.org/toc/2223-7747Researchers are attracted to the wide-ranging, useful components in <i>Aronia melanocarpa</i> berries. They are searching for the most effective ways to extract the active substances that can enhance the body’s protective properties. The current study presents detailed information about the extracts from <i>A. melanocarpa</i> fruits frozen and dried under mild conditions and their chemical composition. In Wistar rats with induced immunosuppression, the effect of chokeberry fruit extracts on the leukocyte formula, phagocytic activity, and cytokine system was studied. It was shown that the <i>A. melanocarpa</i> frozen fruit extract contains more anthocyanins, sugars, and ascorbic acid, and has a more pronounced antioxidant activity determined by the ability to bind APPH-radicals. Moreover, the extract showed membrane-protective and cytoprotective properties against RPMI-1788 cell line. The extract from dried raw material shows a higher antioxidant activity due to the ability to bind DPPH-radicals. It was revealed that extracts from <i>A. melanocarpa</i> fruits promote rapid immune system recovery in rats, normalize the leukocyte count, and improve monocyte and neutrophil phagocytic indicators. Research on the cytokine profile revealed that the anti-inflammatory properties in <i>A. melanocarpa</i> extracts were more pronounced in dried extracts. For several cytokines, a normalization of quantity was noted.Kseniya BushmelevaAlexandra VyshtakalyukDmitriy TerenzhevTimur BelovAndrey ParfenovNatalia SharonovaEvgeniy NikitinVladimir ZobovMDPI AGarticle<i>Aronia melanocarpa</i>black chokeberrybioactive compoundsextractsmethod of preparing raw materialsantioxidant capacityBotanyQK1-989ENPlants, Vol 10, Iss 2458, p 2458 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Aronia melanocarpa</i> black chokeberry bioactive compounds extracts method of preparing raw materials antioxidant capacity Botany QK1-989
spellingShingle	<i>Aronia melanocarpa</i> black chokeberry bioactive compounds extracts method of preparing raw materials antioxidant capacity Botany QK1-989 Kseniya Bushmeleva Alexandra Vyshtakalyuk Dmitriy Terenzhev Timur Belov Andrey Parfenov Natalia Sharonova Evgeniy Nikitin Vladimir Zobov Radical Scavenging Actions and Immunomodulatory Activity of <i>Aronia melanocarpa</i> Propylene Glycol Extracts
description	Researchers are attracted to the wide-ranging, useful components in <i>Aronia melanocarpa</i> berries. They are searching for the most effective ways to extract the active substances that can enhance the body’s protective properties. The current study presents detailed information about the extracts from <i>A. melanocarpa</i> fruits frozen and dried under mild conditions and their chemical composition. In Wistar rats with induced immunosuppression, the effect of chokeberry fruit extracts on the leukocyte formula, phagocytic activity, and cytokine system was studied. It was shown that the <i>A. melanocarpa</i> frozen fruit extract contains more anthocyanins, sugars, and ascorbic acid, and has a more pronounced antioxidant activity determined by the ability to bind APPH-radicals. Moreover, the extract showed membrane-protective and cytoprotective properties against RPMI-1788 cell line. The extract from dried raw material shows a higher antioxidant activity due to the ability to bind DPPH-radicals. It was revealed that extracts from <i>A. melanocarpa</i> fruits promote rapid immune system recovery in rats, normalize the leukocyte count, and improve monocyte and neutrophil phagocytic indicators. Research on the cytokine profile revealed that the anti-inflammatory properties in <i>A. melanocarpa</i> extracts were more pronounced in dried extracts. For several cytokines, a normalization of quantity was noted.
format	article
author	Kseniya Bushmeleva Alexandra Vyshtakalyuk Dmitriy Terenzhev Timur Belov Andrey Parfenov Natalia Sharonova Evgeniy Nikitin Vladimir Zobov
author_facet	Kseniya Bushmeleva Alexandra Vyshtakalyuk Dmitriy Terenzhev Timur Belov Andrey Parfenov Natalia Sharonova Evgeniy Nikitin Vladimir Zobov
author_sort	Kseniya Bushmeleva
title	Radical Scavenging Actions and Immunomodulatory Activity of <i>Aronia melanocarpa</i> Propylene Glycol Extracts
title_short	Radical Scavenging Actions and Immunomodulatory Activity of <i>Aronia melanocarpa</i> Propylene Glycol Extracts
title_full	Radical Scavenging Actions and Immunomodulatory Activity of <i>Aronia melanocarpa</i> Propylene Glycol Extracts
title_fullStr	Radical Scavenging Actions and Immunomodulatory Activity of <i>Aronia melanocarpa</i> Propylene Glycol Extracts
title_full_unstemmed	Radical Scavenging Actions and Immunomodulatory Activity of <i>Aronia melanocarpa</i> Propylene Glycol Extracts
title_sort	radical scavenging actions and immunomodulatory activity of <i>aronia melanocarpa</i> propylene glycol extracts
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/db3d454bbcdb4d8a8fd14047b670467f
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Radical Scavenging Actions and Immunomodulatory Activity of <i>Aronia melanocarpa</i> Propylene Glycol Extracts

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