Could Vitamin D Be Effective in Prevention of Preeclampsia?

Prevention of preeclampsia (PE) remains one of the most significant problems in perinatal medicine. Due to the possible unpredictable course of hypertension in pregnancy, primarily PE and the high complication rate for the mother and fetus/newborn, it is urgent to offer pregnant women in high-risk g...

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Autores principales:	Elżbieta Poniedziałek-Czajkowska, Radzisław Mierzyński
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	preeclampsia vitamin D prophylaxis Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/db3dc80c6c1b413ab9ee87864ab751fa
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spelling	oai:doaj.org-article:db3dc80c6c1b413ab9ee87864ab751fa2021-11-25T18:34:41ZCould Vitamin D Be Effective in Prevention of Preeclampsia?10.3390/nu131138542072-6643https://doaj.org/article/db3dc80c6c1b413ab9ee87864ab751fa2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3854https://doaj.org/toc/2072-6643Prevention of preeclampsia (PE) remains one of the most significant problems in perinatal medicine. Due to the possible unpredictable course of hypertension in pregnancy, primarily PE and the high complication rate for the mother and fetus/newborn, it is urgent to offer pregnant women in high-risk groups effective methods of preventing the PE development or delaying its appearance. In addition, due to the association of PE with an increased risk of developing cardiovascular diseases (CVD) in later life, effective preeclampsia prevention could also be important in reducing their incidence. Ideal PE prophylaxis should target the pathogenetic changes leading to the development of PE and be safe for the mother and fetus, inexpensive and freely available. Currently, the only recognized method of PE prevention recommended by many institutions around the world is the use of a small dose of acetylsalicylic acid in pregnant women with risk factors. Unfortunately, some cases of PE are diagnosed in women without recognized risk factors and in those in whom prophylaxis with acetylsalicylic acid is not adequate. Hence, new drugs which would target pathogenetic elements in the development of preeclampsia are studied. Vitamin D (Vit D) seems to be a promising agent due to its beneficial effect on placental implantation, the immune system, and angiogenic factors. Studies published so far emphasize the relationship of its deficiency with the development of PE, but the data on the benefits of its supplementation to reduce the risk of PE are inconclusive. In the light of current research, the key issue is determining the protective concentration of Vit D in a pregnant woman. The study aims to present the possibility of using Vit D to prevent PE, emphasizing its impact on the pathogenetic elements of preeclampsia development.Elżbieta Poniedziałek-CzajkowskaRadzisław MierzyńskiMDPI AGarticlepreeclampsiavitamin DprophylaxisNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3854, p 3854 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	preeclampsia vitamin D prophylaxis Nutrition. Foods and food supply TX341-641
spellingShingle	preeclampsia vitamin D prophylaxis Nutrition. Foods and food supply TX341-641 Elżbieta Poniedziałek-Czajkowska Radzisław Mierzyński Could Vitamin D Be Effective in Prevention of Preeclampsia?
description	Prevention of preeclampsia (PE) remains one of the most significant problems in perinatal medicine. Due to the possible unpredictable course of hypertension in pregnancy, primarily PE and the high complication rate for the mother and fetus/newborn, it is urgent to offer pregnant women in high-risk groups effective methods of preventing the PE development or delaying its appearance. In addition, due to the association of PE with an increased risk of developing cardiovascular diseases (CVD) in later life, effective preeclampsia prevention could also be important in reducing their incidence. Ideal PE prophylaxis should target the pathogenetic changes leading to the development of PE and be safe for the mother and fetus, inexpensive and freely available. Currently, the only recognized method of PE prevention recommended by many institutions around the world is the use of a small dose of acetylsalicylic acid in pregnant women with risk factors. Unfortunately, some cases of PE are diagnosed in women without recognized risk factors and in those in whom prophylaxis with acetylsalicylic acid is not adequate. Hence, new drugs which would target pathogenetic elements in the development of preeclampsia are studied. Vitamin D (Vit D) seems to be a promising agent due to its beneficial effect on placental implantation, the immune system, and angiogenic factors. Studies published so far emphasize the relationship of its deficiency with the development of PE, but the data on the benefits of its supplementation to reduce the risk of PE are inconclusive. In the light of current research, the key issue is determining the protective concentration of Vit D in a pregnant woman. The study aims to present the possibility of using Vit D to prevent PE, emphasizing its impact on the pathogenetic elements of preeclampsia development.
format	article
author	Elżbieta Poniedziałek-Czajkowska Radzisław Mierzyński
author_facet	Elżbieta Poniedziałek-Czajkowska Radzisław Mierzyński
author_sort	Elżbieta Poniedziałek-Czajkowska
title	Could Vitamin D Be Effective in Prevention of Preeclampsia?
title_short	Could Vitamin D Be Effective in Prevention of Preeclampsia?
title_full	Could Vitamin D Be Effective in Prevention of Preeclampsia?
title_fullStr	Could Vitamin D Be Effective in Prevention of Preeclampsia?
title_full_unstemmed	Could Vitamin D Be Effective in Prevention of Preeclampsia?
title_sort	could vitamin d be effective in prevention of preeclampsia?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/db3dc80c6c1b413ab9ee87864ab751fa
work_keys_str_mv	AT elzbietaponiedziałekczajkowska couldvitamindbeeffectiveinpreventionofpreeclampsia AT radzisławmierzynski couldvitamindbeeffectiveinpreventionofpreeclampsia
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Could Vitamin D Be Effective in Prevention of Preeclampsia?

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