Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes

Patients with diabetes often have delayed wound healing, associated with excessive inflammation. Here the authors report that REG3A inhibits TLR3-driven inflammation in skin wounds, and show that REG3A is reduced in models of diabetes, which exacerbates inflammation in diabetic wounds.

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Autores principales:	Yelin Wu, Yanchun Quan, Yuanqi Liu, Keiwei Liu, Hongquan Li, Ziwei Jiang, Tian Zhang, Hu Lei, Katherine A. Radek, Dongqing Li, Zhenhua Wang, Jilong Lu, Wang Wang, Shizhao Ji, Zhaofan Xia, Yuping Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db4113e335cb482b929e01312771ae8b
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spelling	oai:doaj.org-article:db4113e335cb482b929e01312771ae8b2021-12-02T16:57:05ZHyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes10.1038/ncomms133932041-1723https://doaj.org/article/db4113e335cb482b929e01312771ae8b2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13393https://doaj.org/toc/2041-1723Patients with diabetes often have delayed wound healing, associated with excessive inflammation. Here the authors report that REG3A inhibits TLR3-driven inflammation in skin wounds, and show that REG3A is reduced in models of diabetes, which exacerbates inflammation in diabetic wounds.Yelin WuYanchun QuanYuanqi LiuKeiwei LiuHongquan LiZiwei JiangTian ZhangHu LeiKatherine A. RadekDongqing LiZhenhua WangJilong LuWang WangShizhao JiZhaofan XiaYuping LaiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yelin Wu Yanchun Quan Yuanqi Liu Keiwei Liu Hongquan Li Ziwei Jiang Tian Zhang Hu Lei Katherine A. Radek Dongqing Li Zhenhua Wang Jilong Lu Wang Wang Shizhao Ji Zhaofan Xia Yuping Lai Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes
description	Patients with diabetes often have delayed wound healing, associated with excessive inflammation. Here the authors report that REG3A inhibits TLR3-driven inflammation in skin wounds, and show that REG3A is reduced in models of diabetes, which exacerbates inflammation in diabetic wounds.
format	article
author	Yelin Wu Yanchun Quan Yuanqi Liu Keiwei Liu Hongquan Li Ziwei Jiang Tian Zhang Hu Lei Katherine A. Radek Dongqing Li Zhenhua Wang Jilong Lu Wang Wang Shizhao Ji Zhaofan Xia Yuping Lai
author_facet	Yelin Wu Yanchun Quan Yuanqi Liu Keiwei Liu Hongquan Li Ziwei Jiang Tian Zhang Hu Lei Katherine A. Radek Dongqing Li Zhenhua Wang Jilong Lu Wang Wang Shizhao Ji Zhaofan Xia Yuping Lai
author_sort	Yelin Wu
title	Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes
title_short	Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes
title_full	Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes
title_fullStr	Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes
title_full_unstemmed	Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes
title_sort	hyperglycaemia inhibits reg3a expression to exacerbate tlr3-mediated skin inflammation in diabetes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/db4113e335cb482b929e01312771ae8b
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Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes

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