Historical aspects of etiopathogenesis and treatment of syphilitic infection in Russia (report II)

In the historical aspect, experimental studies on rabbits conducted after the discovery of penicillin are described in order to develop single doses of the antibiotic and the frequency of its administration. The effectiveness of specific therapy of patients with syphilis with crystalline penicillin,...

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Autores principales:	Vyacheslav V. Chebotarev, Mikhail A. Zemtsov, Alexey V. Odinets, Natalia V. Chebotareva
Formato:	article
Lenguaje:	RU
Publicado:	State Scientific Center of Dermatovenereology and Cosmetology 2021
Materias:	syphilis penicillin treatment regimens experimental studies effectiveness of therapy Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/db41aa46c3524d2e9a08144e465ecf3c
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id	oai:doaj.org-article:db41aa46c3524d2e9a08144e465ecf3c
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spelling	oai:doaj.org-article:db41aa46c3524d2e9a08144e465ecf3c2021-12-01T22:16:29ZHistorical aspects of etiopathogenesis and treatment of syphilitic infection in Russia (report II)0042-46092313-629410.25208/vdv1179https://doaj.org/article/db41aa46c3524d2e9a08144e465ecf3c2021-03-01T00:00:00Zhttps://vestnikdv.ru/jour/article/viewFile/1179/1168https://doaj.org/toc/0042-4609https://doaj.org/toc/2313-6294In the historical aspect, experimental studies on rabbits conducted after the discovery of penicillin are described in order to develop single doses of the antibiotic and the frequency of its administration. The effectiveness of specific therapy of patients with syphilis with crystalline penicillin, Durant drugs in monotherapy, in combination with bismuth and non-specific therapy was evaluated. Electron microscopic studies that established the mechanism of action of penicillin on Treponema, the appearance of cysts and L-forms of the pathogen, the role of the macroorganism and stimulating therapy in the completion of phagocytosis are highlighted. It reflects the discussions of leading scientists at congresses that contribute to the development of effective treatment regimens for patients with syphilis.Vyacheslav V. ChebotarevMikhail A. ZemtsovAlexey V. OdinetsNatalia V. ChebotarevaState Scientific Center of Dermatovenereology and Cosmetologyarticlesyphilispenicillintreatment regimensexperimental studieseffectiveness of therapyDermatologyRL1-803RUVestnik Dermatologii i Venerologii, Vol 97, Iss 1, Pp 8-15 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	syphilis penicillin treatment regimens experimental studies effectiveness of therapy Dermatology RL1-803
spellingShingle	syphilis penicillin treatment regimens experimental studies effectiveness of therapy Dermatology RL1-803 Vyacheslav V. Chebotarev Mikhail A. Zemtsov Alexey V. Odinets Natalia V. Chebotareva Historical aspects of etiopathogenesis and treatment of syphilitic infection in Russia (report II)
description	In the historical aspect, experimental studies on rabbits conducted after the discovery of penicillin are described in order to develop single doses of the antibiotic and the frequency of its administration. The effectiveness of specific therapy of patients with syphilis with crystalline penicillin, Durant drugs in monotherapy, in combination with bismuth and non-specific therapy was evaluated. Electron microscopic studies that established the mechanism of action of penicillin on Treponema, the appearance of cysts and L-forms of the pathogen, the role of the macroorganism and stimulating therapy in the completion of phagocytosis are highlighted. It reflects the discussions of leading scientists at congresses that contribute to the development of effective treatment regimens for patients with syphilis.
format	article
author	Vyacheslav V. Chebotarev Mikhail A. Zemtsov Alexey V. Odinets Natalia V. Chebotareva
author_facet	Vyacheslav V. Chebotarev Mikhail A. Zemtsov Alexey V. Odinets Natalia V. Chebotareva
author_sort	Vyacheslav V. Chebotarev
title	Historical aspects of etiopathogenesis and treatment of syphilitic infection in Russia (report II)
title_short	Historical aspects of etiopathogenesis and treatment of syphilitic infection in Russia (report II)
title_full	Historical aspects of etiopathogenesis and treatment of syphilitic infection in Russia (report II)
title_fullStr	Historical aspects of etiopathogenesis and treatment of syphilitic infection in Russia (report II)
title_full_unstemmed	Historical aspects of etiopathogenesis and treatment of syphilitic infection in Russia (report II)
title_sort	historical aspects of etiopathogenesis and treatment of syphilitic infection in russia (report ii)
publisher	State Scientific Center of Dermatovenereology and Cosmetology
publishDate	2021
url	https://doaj.org/article/db41aa46c3524d2e9a08144e465ecf3c
work_keys_str_mv	AT vyacheslavvchebotarev historicalaspectsofetiopathogenesisandtreatmentofsyphiliticinfectioninrussiareportii AT mikhailazemtsov historicalaspectsofetiopathogenesisandtreatmentofsyphiliticinfectioninrussiareportii AT alexeyvodinets historicalaspectsofetiopathogenesisandtreatmentofsyphiliticinfectioninrussiareportii AT nataliavchebotareva historicalaspectsofetiopathogenesisandtreatmentofsyphiliticinfectioninrussiareportii
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Historical aspects of etiopathogenesis and treatment of syphilitic infection in Russia (report II)

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