Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells

Ndfip1 is an activator of Itch E3 ubiquitin ligase that limits T cell activation. Here the authors identify Jak1 in a proteomic screen for Ndfip dependent substrates, and show that Ndfip1/2 double-deficient T cells have reduced degradation of Jak1 and as a result are hyper-responsive to cytokine sti...

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Autores principales:	Claire E. O’Leary, Christopher R. Riling, Lynn A. Spruce, Hua Ding, Suresh Kumar, Guoping Deng, Yuhong Liu, Steven H. Seeholzer, Paula M. Oliver
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db42816efdd94bf7b6b714a9b6e7cec3
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spelling	oai:doaj.org-article:db42816efdd94bf7b6b714a9b6e7cec32021-12-02T17:32:23ZNdfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells10.1038/ncomms112262041-1723https://doaj.org/article/db42816efdd94bf7b6b714a9b6e7cec32016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11226https://doaj.org/toc/2041-1723Ndfip1 is an activator of Itch E3 ubiquitin ligase that limits T cell activation. Here the authors identify Jak1 in a proteomic screen for Ndfip dependent substrates, and show that Ndfip1/2 double-deficient T cells have reduced degradation of Jak1 and as a result are hyper-responsive to cytokine stimulation.Claire E. O’LearyChristopher R. RilingLynn A. SpruceHua DingSuresh KumarGuoping DengYuhong LiuSteven H. SeeholzerPaula M. OliverNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claire E. O’Leary Christopher R. Riling Lynn A. Spruce Hua Ding Suresh Kumar Guoping Deng Yuhong Liu Steven H. Seeholzer Paula M. Oliver Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells
description	Ndfip1 is an activator of Itch E3 ubiquitin ligase that limits T cell activation. Here the authors identify Jak1 in a proteomic screen for Ndfip dependent substrates, and show that Ndfip1/2 double-deficient T cells have reduced degradation of Jak1 and as a result are hyper-responsive to cytokine stimulation.
format	article
author	Claire E. O’Leary Christopher R. Riling Lynn A. Spruce Hua Ding Suresh Kumar Guoping Deng Yuhong Liu Steven H. Seeholzer Paula M. Oliver
author_facet	Claire E. O’Leary Christopher R. Riling Lynn A. Spruce Hua Ding Suresh Kumar Guoping Deng Yuhong Liu Steven H. Seeholzer Paula M. Oliver
author_sort	Claire E. O’Leary
title	Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells
title_short	Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells
title_full	Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells
title_fullStr	Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells
title_full_unstemmed	Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells
title_sort	ndfip-mediated degradation of jak1 tunes cytokine signalling to limit expansion of cd4+ effector t cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/db42816efdd94bf7b6b714a9b6e7cec3
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Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells

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