Antihypertensive Drug Use and the Risk of Depression: A Systematic Review and Network Meta-analysis

Background: Although numerous cohort studies have reported an association between antihypertensives use and depression, the exact effect of antihypertensives on depression remains unclear.Objective: To clarify the association between antihypertensives use and risk of depression.Methods: We retrieved...

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Autores principales:	Ying Li, Yuanming Fan, Yangyang Sun, Raphael N. Alolga, Pingxi Xiao, Gaoxiang Ma
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	antihypertensive medication depression meta-analysis network meta-analysis review Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/db4541808f8f419eb867bf3f787452d1
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spelling	oai:doaj.org-article:db4541808f8f419eb867bf3f787452d12021-11-08T07:46:16ZAntihypertensive Drug Use and the Risk of Depression: A Systematic Review and Network Meta-analysis1663-981210.3389/fphar.2021.777987https://doaj.org/article/db4541808f8f419eb867bf3f787452d12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.777987/fullhttps://doaj.org/toc/1663-9812Background: Although numerous cohort studies have reported an association between antihypertensives use and depression, the exact effect of antihypertensives on depression remains unclear.Objective: To clarify the association between antihypertensives use and risk of depression.Methods: We retrieved relevant literature using PubMed database until August 30, 2021. Four main classes of antihypertensives, thus, angiotensin antagonists, beta blockers, calcium channel blockers and diuretics were studied. The incidence of depression was pooled based on a single drug category. Network meta-analyses were conducted to comprehensively assess the effects of the four classes of antihypertensives on the risk of depression.Results: A total of nine out of 9,557 studies involving 414,873 subjects were retrieved. The pooled results showed a positive association between the use of calcium channel blockers and symptoms of depression [odds ratio (OR): 1.09, 95% confidence interval (CI):1.06–1.13], while use of the angiotensin antagonists, beta blockers and diuretics was not associated with risk of depression. Subgroup analysis suggested a significant relationship between beta blockers usage and risk of depression in cohort studies (OR:1.21, 95% CI: 1.16–1.26). The results of network meta-analysis indicated that all other three classes of drugs increased the risk of depression: angiotensin antagonists (OR: 1.30, 95% CI: 1.04–1.63), beta blockers (OR: 1.53, 95% CI: 1.22–1.91), and calcium channel blockers (OR: 1.40, 95% CI: 1.12–1.75), compared with diuretics.Conclusion: In conclusion, our results indicate that the use of angiotensin antagonists, beta blockers and calcium channel blockers are potential risk factors of depression.Ying LiYuanming FanYangyang SunRaphael N. AlolgaPingxi XiaoGaoxiang MaFrontiers Media S.A.articleantihypertensive medicationdepressionmeta-analysisnetwork meta-analysisreviewTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antihypertensive medication depression meta-analysis network meta-analysis review Therapeutics. Pharmacology RM1-950
spellingShingle	antihypertensive medication depression meta-analysis network meta-analysis review Therapeutics. Pharmacology RM1-950 Ying Li Yuanming Fan Yangyang Sun Raphael N. Alolga Pingxi Xiao Gaoxiang Ma Antihypertensive Drug Use and the Risk of Depression: A Systematic Review and Network Meta-analysis
description	Background: Although numerous cohort studies have reported an association between antihypertensives use and depression, the exact effect of antihypertensives on depression remains unclear.Objective: To clarify the association between antihypertensives use and risk of depression.Methods: We retrieved relevant literature using PubMed database until August 30, 2021. Four main classes of antihypertensives, thus, angiotensin antagonists, beta blockers, calcium channel blockers and diuretics were studied. The incidence of depression was pooled based on a single drug category. Network meta-analyses were conducted to comprehensively assess the effects of the four classes of antihypertensives on the risk of depression.Results: A total of nine out of 9,557 studies involving 414,873 subjects were retrieved. The pooled results showed a positive association between the use of calcium channel blockers and symptoms of depression [odds ratio (OR): 1.09, 95% confidence interval (CI):1.06–1.13], while use of the angiotensin antagonists, beta blockers and diuretics was not associated with risk of depression. Subgroup analysis suggested a significant relationship between beta blockers usage and risk of depression in cohort studies (OR:1.21, 95% CI: 1.16–1.26). The results of network meta-analysis indicated that all other three classes of drugs increased the risk of depression: angiotensin antagonists (OR: 1.30, 95% CI: 1.04–1.63), beta blockers (OR: 1.53, 95% CI: 1.22–1.91), and calcium channel blockers (OR: 1.40, 95% CI: 1.12–1.75), compared with diuretics.Conclusion: In conclusion, our results indicate that the use of angiotensin antagonists, beta blockers and calcium channel blockers are potential risk factors of depression.
format	article
author	Ying Li Yuanming Fan Yangyang Sun Raphael N. Alolga Pingxi Xiao Gaoxiang Ma
author_facet	Ying Li Yuanming Fan Yangyang Sun Raphael N. Alolga Pingxi Xiao Gaoxiang Ma
author_sort	Ying Li
title	Antihypertensive Drug Use and the Risk of Depression: A Systematic Review and Network Meta-analysis
title_short	Antihypertensive Drug Use and the Risk of Depression: A Systematic Review and Network Meta-analysis
title_full	Antihypertensive Drug Use and the Risk of Depression: A Systematic Review and Network Meta-analysis
title_fullStr	Antihypertensive Drug Use and the Risk of Depression: A Systematic Review and Network Meta-analysis
title_full_unstemmed	Antihypertensive Drug Use and the Risk of Depression: A Systematic Review and Network Meta-analysis
title_sort	antihypertensive drug use and the risk of depression: a systematic review and network meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/db4541808f8f419eb867bf3f787452d1
work_keys_str_mv	AT yingli antihypertensivedruguseandtheriskofdepressionasystematicreviewandnetworkmetaanalysis AT yuanmingfan antihypertensivedruguseandtheriskofdepressionasystematicreviewandnetworkmetaanalysis AT yangyangsun antihypertensivedruguseandtheriskofdepressionasystematicreviewandnetworkmetaanalysis AT raphaelnalolga antihypertensivedruguseandtheriskofdepressionasystematicreviewandnetworkmetaanalysis AT pingxixiao antihypertensivedruguseandtheriskofdepressionasystematicreviewandnetworkmetaanalysis AT gaoxiangma antihypertensivedruguseandtheriskofdepressionasystematicreviewandnetworkmetaanalysis
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Antihypertensive Drug Use and the Risk of Depression: A Systematic Review and Network Meta-analysis

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