The Importance of Exosomal PD-L1 in Cancer Progression and Its Potential as a Therapeutic Target

Binding of programmed cell death ligand 1 (PD-L1) to its receptor programmed cell death protein 1 (PD-1) can lead to the inactivation of cytotoxic T lymphocytes, which is one of the mechanisms for immune escape of tumors. Immunotherapy based on this mechanism has been applied in clinic with some rem...

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Autores principales:	Lingxiao Ye, Zhengxin Zhu, Xiaochuan Chen, Haoran Zhang, Jiaqi Huang, Shengxian Gu, Xiaoyin Zhao
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	exosomes exosomal PD-L1 tumor progression therapeutic strategy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/db4619e3a3c8494bbbfc88f7eb44e790
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spelling	oai:doaj.org-article:db4619e3a3c8494bbbfc88f7eb44e7902021-11-25T17:13:15ZThe Importance of Exosomal PD-L1 in Cancer Progression and Its Potential as a Therapeutic Target10.3390/cells101132472073-4409https://doaj.org/article/db4619e3a3c8494bbbfc88f7eb44e7902021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3247https://doaj.org/toc/2073-4409Binding of programmed cell death ligand 1 (PD-L1) to its receptor programmed cell death protein 1 (PD-1) can lead to the inactivation of cytotoxic T lymphocytes, which is one of the mechanisms for immune escape of tumors. Immunotherapy based on this mechanism has been applied in clinic with some remaining issues such as drug resistance. Exosomal PD-L1 derived from tumor cells is considered to play a key role in mediating drug resistance. Here, the effects of various tumor-derived exosomes and tumor-derived exosomal PD-L1 on tumor progression are summarized and discussed. Researchers have found that high expression of exosomal PD-L1 can inhibit T cell activation in in vitro experiments, but the function of exosomal PD-L1 in vivo remains controversial. In addition, the circulating exosomal PD-L1 has high potential to act as an indicator to evaluate the clinical effect. Moreover, therapeutic strategy targeting exosomal PD-L1 is discussed, such as inhibiting the biogenesis or secretion of exosomes. Besides, some specific methods based on the strategy of inhibiting exosomes are concluded. Further study of exosomal PD-L1 may provide an effective and safe approach for tumor treatment, and targeting exosomal PD-L1 by inhibiting exosomes may be a potential method for tumor treatment.Lingxiao YeZhengxin ZhuXiaochuan ChenHaoran ZhangJiaqi HuangShengxian GuXiaoyin ZhaoMDPI AGarticleexosomesexosomal PD-L1tumor progressiontherapeutic strategyBiology (General)QH301-705.5ENCells, Vol 10, Iss 3247, p 3247 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	exosomes exosomal PD-L1 tumor progression therapeutic strategy Biology (General) QH301-705.5
spellingShingle	exosomes exosomal PD-L1 tumor progression therapeutic strategy Biology (General) QH301-705.5 Lingxiao Ye Zhengxin Zhu Xiaochuan Chen Haoran Zhang Jiaqi Huang Shengxian Gu Xiaoyin Zhao The Importance of Exosomal PD-L1 in Cancer Progression and Its Potential as a Therapeutic Target
description	Binding of programmed cell death ligand 1 (PD-L1) to its receptor programmed cell death protein 1 (PD-1) can lead to the inactivation of cytotoxic T lymphocytes, which is one of the mechanisms for immune escape of tumors. Immunotherapy based on this mechanism has been applied in clinic with some remaining issues such as drug resistance. Exosomal PD-L1 derived from tumor cells is considered to play a key role in mediating drug resistance. Here, the effects of various tumor-derived exosomes and tumor-derived exosomal PD-L1 on tumor progression are summarized and discussed. Researchers have found that high expression of exosomal PD-L1 can inhibit T cell activation in in vitro experiments, but the function of exosomal PD-L1 in vivo remains controversial. In addition, the circulating exosomal PD-L1 has high potential to act as an indicator to evaluate the clinical effect. Moreover, therapeutic strategy targeting exosomal PD-L1 is discussed, such as inhibiting the biogenesis or secretion of exosomes. Besides, some specific methods based on the strategy of inhibiting exosomes are concluded. Further study of exosomal PD-L1 may provide an effective and safe approach for tumor treatment, and targeting exosomal PD-L1 by inhibiting exosomes may be a potential method for tumor treatment.
format	article
author	Lingxiao Ye Zhengxin Zhu Xiaochuan Chen Haoran Zhang Jiaqi Huang Shengxian Gu Xiaoyin Zhao
author_facet	Lingxiao Ye Zhengxin Zhu Xiaochuan Chen Haoran Zhang Jiaqi Huang Shengxian Gu Xiaoyin Zhao
author_sort	Lingxiao Ye
title	The Importance of Exosomal PD-L1 in Cancer Progression and Its Potential as a Therapeutic Target
title_short	The Importance of Exosomal PD-L1 in Cancer Progression and Its Potential as a Therapeutic Target
title_full	The Importance of Exosomal PD-L1 in Cancer Progression and Its Potential as a Therapeutic Target
title_fullStr	The Importance of Exosomal PD-L1 in Cancer Progression and Its Potential as a Therapeutic Target
title_full_unstemmed	The Importance of Exosomal PD-L1 in Cancer Progression and Its Potential as a Therapeutic Target
title_sort	importance of exosomal pd-l1 in cancer progression and its potential as a therapeutic target
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/db4619e3a3c8494bbbfc88f7eb44e790
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The Importance of Exosomal PD-L1 in Cancer Progression and Its Potential as a Therapeutic Target

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