A practical guide for mutational signature analysis in hematological malignancies
Mutational signature analysis provides important information about the mutational processes underpinning different stages of tumorigenesis. Here, the authors compare publicly available signature extraction tools and suggest a framework for the generation of accurate and reproducible signature data.
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Nature Portfolio
2019
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| Acceso en línea: | https://doaj.org/article/db472ad80eb543dd8f9c840674ea9d19 |
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oai:doaj.org-article:db472ad80eb543dd8f9c840674ea9d192021-12-02T16:57:21ZA practical guide for mutational signature analysis in hematological malignancies10.1038/s41467-019-11037-82041-1723https://doaj.org/article/db472ad80eb543dd8f9c840674ea9d192019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11037-8https://doaj.org/toc/2041-1723Mutational signature analysis provides important information about the mutational processes underpinning different stages of tumorigenesis. Here, the authors compare publicly available signature extraction tools and suggest a framework for the generation of accurate and reproducible signature data.Francesco MauraAndrea DegasperiFerran NadeuDaniel LeongamornlertHelen DaviesLuiza MooreRomina RoyoBachisio ZicchedduXose S. PuenteHerve Avet-LoiseauPeter J. CampbellSerena Nik-ZainalElias CampoNikhil MunshiNiccolò BolliNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Francesco Maura Andrea Degasperi Ferran Nadeu Daniel Leongamornlert Helen Davies Luiza Moore Romina Royo Bachisio Ziccheddu Xose S. Puente Herve Avet-Loiseau Peter J. Campbell Serena Nik-Zainal Elias Campo Nikhil Munshi Niccolò Bolli A practical guide for mutational signature analysis in hematological malignancies |
| description |
Mutational signature analysis provides important information about the mutational processes underpinning different stages of tumorigenesis. Here, the authors compare publicly available signature extraction tools and suggest a framework for the generation of accurate and reproducible signature data. |
| format |
article |
| author |
Francesco Maura Andrea Degasperi Ferran Nadeu Daniel Leongamornlert Helen Davies Luiza Moore Romina Royo Bachisio Ziccheddu Xose S. Puente Herve Avet-Loiseau Peter J. Campbell Serena Nik-Zainal Elias Campo Nikhil Munshi Niccolò Bolli |
| author_facet |
Francesco Maura Andrea Degasperi Ferran Nadeu Daniel Leongamornlert Helen Davies Luiza Moore Romina Royo Bachisio Ziccheddu Xose S. Puente Herve Avet-Loiseau Peter J. Campbell Serena Nik-Zainal Elias Campo Nikhil Munshi Niccolò Bolli |
| author_sort |
Francesco Maura |
| title |
A practical guide for mutational signature analysis in hematological malignancies |
| title_short |
A practical guide for mutational signature analysis in hematological malignancies |
| title_full |
A practical guide for mutational signature analysis in hematological malignancies |
| title_fullStr |
A practical guide for mutational signature analysis in hematological malignancies |
| title_full_unstemmed |
A practical guide for mutational signature analysis in hematological malignancies |
| title_sort |
practical guide for mutational signature analysis in hematological malignancies |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/db472ad80eb543dd8f9c840674ea9d19 |
| work_keys_str_mv |
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