Albumin-Bilirubin Score for Prediction of Outcomes in Heart Failure Patients Treated with Cardiac Resynchronization Therapy

Background: Liver function may be a useful indicator of response to cardiac resynchronization therapy (CRT). We aimed to investigate the clinical significance of albumin-bilirubin (ALBI) score, an assessment tool of liver function, on outcomes in heart failure (HF) patients treated with CRT. Methods...

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Autores principales:	Shinya Yamada, Takashi Kaneshiro, Akiomi Yoshihisa, Minoru Nodera, Kazuaki Amami, Takeshi Nehashi, Yasuchika Takeishi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	albumin-bilirubin score cardiac resynchronization therapy liver function clinical outcomes Medicine R
Acceso en línea:	https://doaj.org/article/db4b40f203c6492584cc0a78e31e587d
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spelling	oai:doaj.org-article:db4b40f203c6492584cc0a78e31e587d2021-11-25T18:02:15ZAlbumin-Bilirubin Score for Prediction of Outcomes in Heart Failure Patients Treated with Cardiac Resynchronization Therapy10.3390/jcm102253782077-0383https://doaj.org/article/db4b40f203c6492584cc0a78e31e587d2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5378https://doaj.org/toc/2077-0383Background: Liver function may be a useful indicator of response to cardiac resynchronization therapy (CRT). We aimed to investigate the clinical significance of albumin-bilirubin (ALBI) score, an assessment tool of liver function, on outcomes in heart failure (HF) patients treated with CRT. Methods: We studied 180 patients undergoing CRT. The ALBI score, derived from albumin and total bilirubin, and left ventricular ejection fraction (LVEF) were assessed before and 6 months after CRT. The patients were classified according to the ALBI score before CRT; High (>−2.60) or Low (≤−2.60) ALBI groups. The patients were then reclassified based on the ALBI score before and 6 months after CRT; High/High, High/Low, Low/High, and Low/Low ALBI groups. We evaluated the prognostic value of the ALBI score for HF deaths after CRT. Results: During a median follow-up period of 50 months, there were 41 (22.7%) HF deaths. A Cox proportional hazard analysis revealed that high ALBI scores at baseline were not related to HF deaths (hazard ratio, 1.907, <i>p</i> = 0.068). However, High/High ALBI scores, but not High/Low or Low/High ALBI scores, were an independent predictor of HF deaths compared with Low/Low ALBI scores (hazard ratio, 3.449, <i>p</i> = 0.008), implying that consistently high ALBI scores were associated with poor prognosis. The percentage change in LVEF from baseline to 6 months after CRT did not differ among the four groups, suggesting that left ventricular systolic function was not linked with the ALBI score. Conclusions: ALBI scores before and after CRT are a new indicator of CRT response, and have a predictive value for HF deaths in HF patients.Shinya YamadaTakashi KaneshiroAkiomi YoshihisaMinoru NoderaKazuaki AmamiTakeshi NehashiYasuchika TakeishiMDPI AGarticlealbumin-bilirubin scorecardiac resynchronization therapyliver functionclinical outcomesMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5378, p 5378 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	albumin-bilirubin score cardiac resynchronization therapy liver function clinical outcomes Medicine R
spellingShingle	albumin-bilirubin score cardiac resynchronization therapy liver function clinical outcomes Medicine R Shinya Yamada Takashi Kaneshiro Akiomi Yoshihisa Minoru Nodera Kazuaki Amami Takeshi Nehashi Yasuchika Takeishi Albumin-Bilirubin Score for Prediction of Outcomes in Heart Failure Patients Treated with Cardiac Resynchronization Therapy
description	Background: Liver function may be a useful indicator of response to cardiac resynchronization therapy (CRT). We aimed to investigate the clinical significance of albumin-bilirubin (ALBI) score, an assessment tool of liver function, on outcomes in heart failure (HF) patients treated with CRT. Methods: We studied 180 patients undergoing CRT. The ALBI score, derived from albumin and total bilirubin, and left ventricular ejection fraction (LVEF) were assessed before and 6 months after CRT. The patients were classified according to the ALBI score before CRT; High (>−2.60) or Low (≤−2.60) ALBI groups. The patients were then reclassified based on the ALBI score before and 6 months after CRT; High/High, High/Low, Low/High, and Low/Low ALBI groups. We evaluated the prognostic value of the ALBI score for HF deaths after CRT. Results: During a median follow-up period of 50 months, there were 41 (22.7%) HF deaths. A Cox proportional hazard analysis revealed that high ALBI scores at baseline were not related to HF deaths (hazard ratio, 1.907, <i>p</i> = 0.068). However, High/High ALBI scores, but not High/Low or Low/High ALBI scores, were an independent predictor of HF deaths compared with Low/Low ALBI scores (hazard ratio, 3.449, <i>p</i> = 0.008), implying that consistently high ALBI scores were associated with poor prognosis. The percentage change in LVEF from baseline to 6 months after CRT did not differ among the four groups, suggesting that left ventricular systolic function was not linked with the ALBI score. Conclusions: ALBI scores before and after CRT are a new indicator of CRT response, and have a predictive value for HF deaths in HF patients.
format	article
author	Shinya Yamada Takashi Kaneshiro Akiomi Yoshihisa Minoru Nodera Kazuaki Amami Takeshi Nehashi Yasuchika Takeishi
author_facet	Shinya Yamada Takashi Kaneshiro Akiomi Yoshihisa Minoru Nodera Kazuaki Amami Takeshi Nehashi Yasuchika Takeishi
author_sort	Shinya Yamada
title	Albumin-Bilirubin Score for Prediction of Outcomes in Heart Failure Patients Treated with Cardiac Resynchronization Therapy
title_short	Albumin-Bilirubin Score for Prediction of Outcomes in Heart Failure Patients Treated with Cardiac Resynchronization Therapy
title_full	Albumin-Bilirubin Score for Prediction of Outcomes in Heart Failure Patients Treated with Cardiac Resynchronization Therapy
title_fullStr	Albumin-Bilirubin Score for Prediction of Outcomes in Heart Failure Patients Treated with Cardiac Resynchronization Therapy
title_full_unstemmed	Albumin-Bilirubin Score for Prediction of Outcomes in Heart Failure Patients Treated with Cardiac Resynchronization Therapy
title_sort	albumin-bilirubin score for prediction of outcomes in heart failure patients treated with cardiac resynchronization therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/db4b40f203c6492584cc0a78e31e587d
work_keys_str_mv	AT shinyayamada albuminbilirubinscoreforpredictionofoutcomesinheartfailurepatientstreatedwithcardiacresynchronizationtherapy AT takashikaneshiro albuminbilirubinscoreforpredictionofoutcomesinheartfailurepatientstreatedwithcardiacresynchronizationtherapy AT akiomiyoshihisa albuminbilirubinscoreforpredictionofoutcomesinheartfailurepatientstreatedwithcardiacresynchronizationtherapy AT minorunodera albuminbilirubinscoreforpredictionofoutcomesinheartfailurepatientstreatedwithcardiacresynchronizationtherapy AT kazuakiamami albuminbilirubinscoreforpredictionofoutcomesinheartfailurepatientstreatedwithcardiacresynchronizationtherapy AT takeshinehashi albuminbilirubinscoreforpredictionofoutcomesinheartfailurepatientstreatedwithcardiacresynchronizationtherapy AT yasuchikatakeishi albuminbilirubinscoreforpredictionofoutcomesinheartfailurepatientstreatedwithcardiacresynchronizationtherapy
_version_	1718411711063523328

Albumin-Bilirubin Score for Prediction of Outcomes in Heart Failure Patients Treated with Cardiac Resynchronization Therapy

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