Selective deletion of SHIP-1 in hematopoietic cells in mice leads to severe lung inflammation involving ILC2 cells

Selective deletion of SHIP-1 in hematopoietic cells in mice leads to severe lung inflammation involving ILC2 cells

Abstract Src homology 2 domain–containing inositol 5-phosphatase 1 (SHIP-1) regulates the intracellular levels of phosphotidylinositol-3, 4, 5-trisphosphate, a phosphoinositide 3–kinase (PI3K) product. Emerging evidence suggests that the PI3K pathway is involved in allergic inflammation in the lung....

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Main Authors: Xujun Ye, Fengrui Zhang, Li Zhou, Yadong Wei, Li Zhang, Lihui Wang, Haiying Tang, Zi Chen, William G. Kerr, Tao Zheng, Zhou Zhu
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/db4c1bfc8dd248e78232dd2b1a107fb3
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https://doaj.org/article/db4c1bfc8dd248e78232dd2b1a107fb3

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