HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease

Hypoxia inducible factor (HIF)-2α transcription factor is mutated in polycythemia and various neuroendocrine tumors. Here the authors present the crystal structure of a HIF-2α peptide bound to the pVHL-elongin B-elongin C (VBC) heterotrimeric complex and propose a classification scheme for HIF-2α mu...

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Autores principales:	Daniel Tarade, Claire M. Robinson, Jeffrey E. Lee, Michael Ohh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db4f15857e80480b8d26763e42ee2894
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spelling	oai:doaj.org-article:db4f15857e80480b8d26763e42ee28942021-12-02T14:39:24ZHIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease10.1038/s41467-018-05554-12041-1723https://doaj.org/article/db4f15857e80480b8d26763e42ee28942018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05554-1https://doaj.org/toc/2041-1723Hypoxia inducible factor (HIF)-2α transcription factor is mutated in polycythemia and various neuroendocrine tumors. Here the authors present the crystal structure of a HIF-2α peptide bound to the pVHL-elongin B-elongin C (VBC) heterotrimeric complex and propose a classification scheme for HIF-2α mutations that helps to predict disease phenotype outcome.Daniel TaradeClaire M. RobinsonJeffrey E. LeeMichael OhhNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Tarade Claire M. Robinson Jeffrey E. Lee Michael Ohh HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
description	Hypoxia inducible factor (HIF)-2α transcription factor is mutated in polycythemia and various neuroendocrine tumors. Here the authors present the crystal structure of a HIF-2α peptide bound to the pVHL-elongin B-elongin C (VBC) heterotrimeric complex and propose a classification scheme for HIF-2α mutations that helps to predict disease phenotype outcome.
format	article
author	Daniel Tarade Claire M. Robinson Jeffrey E. Lee Michael Ohh
author_facet	Daniel Tarade Claire M. Robinson Jeffrey E. Lee Michael Ohh
author_sort	Daniel Tarade
title	HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
title_short	HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
title_full	HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
title_fullStr	HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
title_full_unstemmed	HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
title_sort	hif-2α-pvhl complex reveals broad genotype-phenotype correlations in hif-2α-driven disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/db4f15857e80480b8d26763e42ee2894
work_keys_str_mv	AT danieltarade hif2apvhlcomplexrevealsbroadgenotypephenotypecorrelationsinhif2adrivendisease AT clairemrobinson hif2apvhlcomplexrevealsbroadgenotypephenotypecorrelationsinhif2adrivendisease AT jeffreyelee hif2apvhlcomplexrevealsbroadgenotypephenotypecorrelationsinhif2adrivendisease AT michaelohh hif2apvhlcomplexrevealsbroadgenotypephenotypecorrelationsinhif2adrivendisease
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HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease

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