High expression of IMPDH2 is associated with aggressive features and poor prognosis of primary nasopharyngeal carcinoma
Abstract Inosine monophosphate dehydrogenase type II (IMPDH2) has been shown to play critical roles in the development and progression of several human cancers. However, little is known about IMPDH2 expression and its clinical significance in nasopharyngeal carcinoma (NPC). Western blotting, qRT-PCR...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/db532c9ec1bd49c18385d3fd3e0f63aa |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:db532c9ec1bd49c18385d3fd3e0f63aa |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:db532c9ec1bd49c18385d3fd3e0f63aa2021-12-02T16:06:28ZHigh expression of IMPDH2 is associated with aggressive features and poor prognosis of primary nasopharyngeal carcinoma10.1038/s41598-017-00887-12045-2322https://doaj.org/article/db532c9ec1bd49c18385d3fd3e0f63aa2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00887-1https://doaj.org/toc/2045-2322Abstract Inosine monophosphate dehydrogenase type II (IMPDH2) has been shown to play critical roles in the development and progression of several human cancers. However, little is known about IMPDH2 expression and its clinical significance in nasopharyngeal carcinoma (NPC). Western blotting, qRT-PCR and immunohistochemistry were employed to evaluate IMPDH2 expression in NPC cell lines and tissues. In our study, elevated expression of IMPDH2 was observed at both the protein and mRNA levels in NPC cell lines than in NPEC2 Bmi-1. IMPDH2 protein expression was markedly higher in NPC tissues than in adjacent non-tumorous tissues. Moreover, IMPDH2 expression in NPC correlated with several clinicopathological parameters, including T classification (P = 0.023), TNM stage (P = 0.020), distant metastasis (P = 0.001) and death (P = 0.002). Further Cox regression analysis suggested that IMPDH2 expression was an independent prognostic factor for overall survival (P = 0.001) and disease-free survival (P < 0.001). In addition, stratified survival analysis showed that high expression of IMPDH2 could be a prognostic factor for NPC patients with TNM stage I/II (OS: P = 0.012; DMFS: P = 0.007), TNM stage III/IV (OS: P = 0.028; DMFS: P = 0.020). Our study demonstrates IMPDH2 may be served as an independent prognostic biomarker for NPC patients, in which high IMPDH expression suggests poor prognosis of NPC patients.Yi XuZhousan ZhengYing GaoShiyu DuanCui ChenJian RongKebing WangMiao YunHuiwen WengSheng YeJiaxing ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Yi Xu Zhousan Zheng Ying Gao Shiyu Duan Cui Chen Jian Rong Kebing Wang Miao Yun Huiwen Weng Sheng Ye Jiaxing Zhang High expression of IMPDH2 is associated with aggressive features and poor prognosis of primary nasopharyngeal carcinoma |
| description |
Abstract Inosine monophosphate dehydrogenase type II (IMPDH2) has been shown to play critical roles in the development and progression of several human cancers. However, little is known about IMPDH2 expression and its clinical significance in nasopharyngeal carcinoma (NPC). Western blotting, qRT-PCR and immunohistochemistry were employed to evaluate IMPDH2 expression in NPC cell lines and tissues. In our study, elevated expression of IMPDH2 was observed at both the protein and mRNA levels in NPC cell lines than in NPEC2 Bmi-1. IMPDH2 protein expression was markedly higher in NPC tissues than in adjacent non-tumorous tissues. Moreover, IMPDH2 expression in NPC correlated with several clinicopathological parameters, including T classification (P = 0.023), TNM stage (P = 0.020), distant metastasis (P = 0.001) and death (P = 0.002). Further Cox regression analysis suggested that IMPDH2 expression was an independent prognostic factor for overall survival (P = 0.001) and disease-free survival (P < 0.001). In addition, stratified survival analysis showed that high expression of IMPDH2 could be a prognostic factor for NPC patients with TNM stage I/II (OS: P = 0.012; DMFS: P = 0.007), TNM stage III/IV (OS: P = 0.028; DMFS: P = 0.020). Our study demonstrates IMPDH2 may be served as an independent prognostic biomarker for NPC patients, in which high IMPDH expression suggests poor prognosis of NPC patients. |
| format |
article |
| author |
Yi Xu Zhousan Zheng Ying Gao Shiyu Duan Cui Chen Jian Rong Kebing Wang Miao Yun Huiwen Weng Sheng Ye Jiaxing Zhang |
| author_facet |
Yi Xu Zhousan Zheng Ying Gao Shiyu Duan Cui Chen Jian Rong Kebing Wang Miao Yun Huiwen Weng Sheng Ye Jiaxing Zhang |
| author_sort |
Yi Xu |
| title |
High expression of IMPDH2 is associated with aggressive features and poor prognosis of primary nasopharyngeal carcinoma |
| title_short |
High expression of IMPDH2 is associated with aggressive features and poor prognosis of primary nasopharyngeal carcinoma |
| title_full |
High expression of IMPDH2 is associated with aggressive features and poor prognosis of primary nasopharyngeal carcinoma |
| title_fullStr |
High expression of IMPDH2 is associated with aggressive features and poor prognosis of primary nasopharyngeal carcinoma |
| title_full_unstemmed |
High expression of IMPDH2 is associated with aggressive features and poor prognosis of primary nasopharyngeal carcinoma |
| title_sort |
high expression of impdh2 is associated with aggressive features and poor prognosis of primary nasopharyngeal carcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/db532c9ec1bd49c18385d3fd3e0f63aa |
| work_keys_str_mv |
AT yixu highexpressionofimpdh2isassociatedwithaggressivefeaturesandpoorprognosisofprimarynasopharyngealcarcinoma AT zhousanzheng highexpressionofimpdh2isassociatedwithaggressivefeaturesandpoorprognosisofprimarynasopharyngealcarcinoma AT yinggao highexpressionofimpdh2isassociatedwithaggressivefeaturesandpoorprognosisofprimarynasopharyngealcarcinoma AT shiyuduan highexpressionofimpdh2isassociatedwithaggressivefeaturesandpoorprognosisofprimarynasopharyngealcarcinoma AT cuichen highexpressionofimpdh2isassociatedwithaggressivefeaturesandpoorprognosisofprimarynasopharyngealcarcinoma AT jianrong highexpressionofimpdh2isassociatedwithaggressivefeaturesandpoorprognosisofprimarynasopharyngealcarcinoma AT kebingwang highexpressionofimpdh2isassociatedwithaggressivefeaturesandpoorprognosisofprimarynasopharyngealcarcinoma AT miaoyun highexpressionofimpdh2isassociatedwithaggressivefeaturesandpoorprognosisofprimarynasopharyngealcarcinoma AT huiwenweng highexpressionofimpdh2isassociatedwithaggressivefeaturesandpoorprognosisofprimarynasopharyngealcarcinoma AT shengye highexpressionofimpdh2isassociatedwithaggressivefeaturesandpoorprognosisofprimarynasopharyngealcarcinoma AT jiaxingzhang highexpressionofimpdh2isassociatedwithaggressivefeaturesandpoorprognosisofprimarynasopharyngealcarcinoma |
| _version_ |
1718384993239040000 |