Treatment of neurolept-induced tardive dyskinesia

Stacey K Jankelowitz Central Clinical School, University of Sydney, Sydney, NSW, Australia Abstract: Tardive dyskinesia (TDK) includes orobuccolingual movements and “piano-playing” movements of the limbs. It is a movement disorder of delayed onset that can occur in the setting of...

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Autor principal:	Jankelowitz SK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/db55b0b8c8934be9923f159ede15a2bd
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spelling	oai:doaj.org-article:db55b0b8c8934be9923f159ede15a2bd2021-12-02T01:42:14ZTreatment of neurolept-induced tardive dyskinesia1176-63281178-2021https://doaj.org/article/db55b0b8c8934be9923f159ede15a2bd2013-09-01T00:00:00Zhttp://www.dovepress.com/treatment-of-neurolept-induced-tardive-dyskinesia-a14371https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Stacey K Jankelowitz Central Clinical School, University of Sydney, Sydney, NSW, Australia Abstract: Tardive dyskinesia (TDK) includes orobuccolingual movements and “piano-playing” movements of the limbs. It is a movement disorder of delayed onset that can occur in the setting of neuroleptic treatment as well as in other diseases and following treatment with other drugs. The specific pathophysiology resulting in TDK is still not completely understood but possible mechanisms include postsynaptic dopamine receptor hypersensitivity, abnormalities of striatal gamma-aminobutyric acid (GABA) neurons, and degeneration of striatal cholinergic interneurons. More recently, the theory of synaptic plasticity has been proposed. Considering these proposed mechanisms of disease, therapeutic interventions have attempted to manipulate dopamine, GABA, acetylcholine, norepinephrine and serotonin pathways and receptors. The data for the effectiveness of each class of drugs and the side effects were considered in turn. Keywords: tardive dyskinesia, treatment, neuroleptic agentsJankelowitz SKDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 1371-1380 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Jankelowitz SK Treatment of neurolept-induced tardive dyskinesia
description	Stacey K Jankelowitz Central Clinical School, University of Sydney, Sydney, NSW, Australia Abstract: Tardive dyskinesia (TDK) includes orobuccolingual movements and “piano-playing” movements of the limbs. It is a movement disorder of delayed onset that can occur in the setting of neuroleptic treatment as well as in other diseases and following treatment with other drugs. The specific pathophysiology resulting in TDK is still not completely understood but possible mechanisms include postsynaptic dopamine receptor hypersensitivity, abnormalities of striatal gamma-aminobutyric acid (GABA) neurons, and degeneration of striatal cholinergic interneurons. More recently, the theory of synaptic plasticity has been proposed. Considering these proposed mechanisms of disease, therapeutic interventions have attempted to manipulate dopamine, GABA, acetylcholine, norepinephrine and serotonin pathways and receptors. The data for the effectiveness of each class of drugs and the side effects were considered in turn. Keywords: tardive dyskinesia, treatment, neuroleptic agents
format	article
author	Jankelowitz SK
author_facet	Jankelowitz SK
author_sort	Jankelowitz SK
title	Treatment of neurolept-induced tardive dyskinesia
title_short	Treatment of neurolept-induced tardive dyskinesia
title_full	Treatment of neurolept-induced tardive dyskinesia
title_fullStr	Treatment of neurolept-induced tardive dyskinesia
title_full_unstemmed	Treatment of neurolept-induced tardive dyskinesia
title_sort	treatment of neurolept-induced tardive dyskinesia
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/db55b0b8c8934be9923f159ede15a2bd
work_keys_str_mv	AT jankelowitzsk treatmentofneuroleptinducedtardivedyskinesia
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Treatment of neurolept-induced tardive dyskinesia

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