Dissociation and Brain Rhythms: Pitfalls and Promises

Recently, Vesuna et al. proposed a novel circuit mechanism underlying dissociative states using optogenetics and pharmacology in mice in combination with intracranial recordings and electrical stimulation in an epilepsy patient. Specifically, the authors identified a posteromedial cortical delta-rhy...

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Autores principales:	Tineke Grent-'t-Jong, Lucia Melloni, Peter J. Uhlhaas
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	dissociation ketamine neural oscillations optogenetics animal models translational neuroscience Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/db56a55544d14499a07ae2399fd9ab11
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spelling	oai:doaj.org-article:db56a55544d14499a07ae2399fd9ab112021-12-03T05:18:58ZDissociation and Brain Rhythms: Pitfalls and Promises1664-064010.3389/fpsyt.2021.790372https://doaj.org/article/db56a55544d14499a07ae2399fd9ab112021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.790372/fullhttps://doaj.org/toc/1664-0640Recently, Vesuna et al. proposed a novel circuit mechanism underlying dissociative states using optogenetics and pharmacology in mice in combination with intracranial recordings and electrical stimulation in an epilepsy patient. Specifically, the authors identified a posteromedial cortical delta-rhythm that underlies states of dissociation. In the following, we would like to critically review these findings in the context of the human literature on dissociation as well as highlight the challenges in translational neuroscience to link complex behavioral phenotypes in psychiatric syndromes to circumscribed circuit mechanisms.Tineke Grent-'t-JongLucia MelloniLucia MelloniPeter J. UhlhaasPeter J. UhlhaasFrontiers Media S.A.articledissociationketamineneural oscillationsoptogeneticsanimal modelstranslational neurosciencePsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dissociation ketamine neural oscillations optogenetics animal models translational neuroscience Psychiatry RC435-571
spellingShingle	dissociation ketamine neural oscillations optogenetics animal models translational neuroscience Psychiatry RC435-571 Tineke Grent-'t-Jong Lucia Melloni Lucia Melloni Peter J. Uhlhaas Peter J. Uhlhaas Dissociation and Brain Rhythms: Pitfalls and Promises
description	Recently, Vesuna et al. proposed a novel circuit mechanism underlying dissociative states using optogenetics and pharmacology in mice in combination with intracranial recordings and electrical stimulation in an epilepsy patient. Specifically, the authors identified a posteromedial cortical delta-rhythm that underlies states of dissociation. In the following, we would like to critically review these findings in the context of the human literature on dissociation as well as highlight the challenges in translational neuroscience to link complex behavioral phenotypes in psychiatric syndromes to circumscribed circuit mechanisms.
format	article
author	Tineke Grent-'t-Jong Lucia Melloni Lucia Melloni Peter J. Uhlhaas Peter J. Uhlhaas
author_facet	Tineke Grent-'t-Jong Lucia Melloni Lucia Melloni Peter J. Uhlhaas Peter J. Uhlhaas
author_sort	Tineke Grent-'t-Jong
title	Dissociation and Brain Rhythms: Pitfalls and Promises
title_short	Dissociation and Brain Rhythms: Pitfalls and Promises
title_full	Dissociation and Brain Rhythms: Pitfalls and Promises
title_fullStr	Dissociation and Brain Rhythms: Pitfalls and Promises
title_full_unstemmed	Dissociation and Brain Rhythms: Pitfalls and Promises
title_sort	dissociation and brain rhythms: pitfalls and promises
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/db56a55544d14499a07ae2399fd9ab11
work_keys_str_mv	AT tinekegrenttjong dissociationandbrainrhythmspitfallsandpromises AT luciamelloni dissociationandbrainrhythmspitfallsandpromises AT luciamelloni dissociationandbrainrhythmspitfallsandpromises AT peterjuhlhaas dissociationandbrainrhythmspitfallsandpromises AT peterjuhlhaas dissociationandbrainrhythmspitfallsandpromises
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Dissociation and Brain Rhythms: Pitfalls and Promises

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