Current perspectives in stem cell research for knee cartilage repair

Patrick Orth,1 Ana Rey-Rico,2 Jagadeesh K Venkatesan,2 Henning Madry,1,2 Magali Cucchiarini2 1Department of Orthopaedic Surgery, 2Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, Germany Abstract: Protocols based on the delivery of stem cells are currently applied...

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Autores principales:	Orth P, Rey-Rico A, Venkatesan JK, Madry H, Cucchiarini M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/db56f640da2c4b41831b46feb1fcc14a
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spelling	oai:doaj.org-article:db56f640da2c4b41831b46feb1fcc14a2021-12-02T04:41:33ZCurrent perspectives in stem cell research for knee cartilage repair1178-6957https://doaj.org/article/db56f640da2c4b41831b46feb1fcc14a2014-01-01T00:00:00Zhttp://www.dovepress.com/current-perspectives-in-stem-cell-research-for-knee-cartilage-repair-a15540https://doaj.org/toc/1178-6957 Patrick Orth,1 Ana Rey-Rico,2 Jagadeesh K Venkatesan,2 Henning Madry,1,2 Magali Cucchiarini2 1Department of Orthopaedic Surgery, 2Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, Germany Abstract: Protocols based on the delivery of stem cells are currently applied in patients, showing encouraging results for the treatment of articular cartilage lesions (focal defects, osteoarthritis). Yet, restoration of a fully functional cartilage surface (native structural organization and mechanical functions) especially in the knee joint has not been reported to date, showing the need for improved designs of clinical trials. Various sources of progenitor cells are now available, originating from adult tissues but also from embryonic or reprogrammed tissues, most of which have already been evaluated for their chondrogenic potential in culture and for their reparative properties in vivo upon implantation in relevant animal models of cartilage lesions. Nevertheless, particular attention will be needed regarding their safe clinical use and their potential to form a cartilaginous repair tissue of proper quality and functionality in the patient. Possible improvements may reside in the use of biological supplements in accordance with regulations, while some challenges remain in establishing standardized, effective procedures in the clinics. Keywords: cartilage repair, knee, focal defects, osteoarthritis, stem cells, clinical trialsOrth PRey-Rico AVenkatesan JKMadry HCucchiarini MDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2014, Iss default, Pp 1-17 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Orth P Rey-Rico A Venkatesan JK Madry H Cucchiarini M Current perspectives in stem cell research for knee cartilage repair
description	Patrick Orth,1 Ana Rey-Rico,2 Jagadeesh K Venkatesan,2 Henning Madry,1,2 Magali Cucchiarini2 1Department of Orthopaedic Surgery, 2Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, Germany Abstract: Protocols based on the delivery of stem cells are currently applied in patients, showing encouraging results for the treatment of articular cartilage lesions (focal defects, osteoarthritis). Yet, restoration of a fully functional cartilage surface (native structural organization and mechanical functions) especially in the knee joint has not been reported to date, showing the need for improved designs of clinical trials. Various sources of progenitor cells are now available, originating from adult tissues but also from embryonic or reprogrammed tissues, most of which have already been evaluated for their chondrogenic potential in culture and for their reparative properties in vivo upon implantation in relevant animal models of cartilage lesions. Nevertheless, particular attention will be needed regarding their safe clinical use and their potential to form a cartilaginous repair tissue of proper quality and functionality in the patient. Possible improvements may reside in the use of biological supplements in accordance with regulations, while some challenges remain in establishing standardized, effective procedures in the clinics. Keywords: cartilage repair, knee, focal defects, osteoarthritis, stem cells, clinical trials
format	article
author	Orth P Rey-Rico A Venkatesan JK Madry H Cucchiarini M
author_facet	Orth P Rey-Rico A Venkatesan JK Madry H Cucchiarini M
author_sort	Orth P
title	Current perspectives in stem cell research for knee cartilage repair
title_short	Current perspectives in stem cell research for knee cartilage repair
title_full	Current perspectives in stem cell research for knee cartilage repair
title_fullStr	Current perspectives in stem cell research for knee cartilage repair
title_full_unstemmed	Current perspectives in stem cell research for knee cartilage repair
title_sort	current perspectives in stem cell research for knee cartilage repair
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/db56f640da2c4b41831b46feb1fcc14a
work_keys_str_mv	AT orthp currentperspectivesinstemcellresearchforkneecartilagerepair AT reyricoa currentperspectivesinstemcellresearchforkneecartilagerepair AT venkatesanjk currentperspectivesinstemcellresearchforkneecartilagerepair AT madryh currentperspectivesinstemcellresearchforkneecartilagerepair AT cucchiarinim currentperspectivesinstemcellresearchforkneecartilagerepair
_version_	1718401155231383552

Current perspectives in stem cell research for knee cartilage repair

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