Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling

Al Alwan et al. describe the tethering and rolling behaviour of leukemic cells by using a microfluidic platform that mimics the endothelial surface under flow conditions. With single-molecule live cell fluorescence imaging, they show that unique spatiotemporal dynamics of selectin ligands on the mem...

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Autores principales:	Bader Al Alwan, Karmen AbuZineh, Shuho Nozue, Aigerim Rakhmatulina, Mansour Aldehaiman, Asma S. Al-Amoodi, Maged F. Serag, Fajr A. Aleisa, Jasmeen S. Merzaban, Satoshi Habuchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/db5aefcd77744f5b97409746ef597d78
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spelling	oai:doaj.org-article:db5aefcd77744f5b97409746ef597d782021-12-02T16:09:41ZSingle-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling10.1038/s42003-021-02398-22399-3642https://doaj.org/article/db5aefcd77744f5b97409746ef597d782021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02398-2https://doaj.org/toc/2399-3642Al Alwan et al. describe the tethering and rolling behaviour of leukemic cells by using a microfluidic platform that mimics the endothelial surface under flow conditions. With single-molecule live cell fluorescence imaging, they show that unique spatiotemporal dynamics of selectin ligands on the membrane tethers and slings play an essential role in the rolling of the cell.Bader Al AlwanKarmen AbuZinehShuho NozueAigerim RakhmatulinaMansour AldehaimanAsma S. Al-AmoodiMaged F. SeragFajr A. AleisaJasmeen S. MerzabanSatoshi HabuchiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Bader Al Alwan Karmen AbuZineh Shuho Nozue Aigerim Rakhmatulina Mansour Aldehaiman Asma S. Al-Amoodi Maged F. Serag Fajr A. Aleisa Jasmeen S. Merzaban Satoshi Habuchi Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling
description	Al Alwan et al. describe the tethering and rolling behaviour of leukemic cells by using a microfluidic platform that mimics the endothelial surface under flow conditions. With single-molecule live cell fluorescence imaging, they show that unique spatiotemporal dynamics of selectin ligands on the membrane tethers and slings play an essential role in the rolling of the cell.
format	article
author	Bader Al Alwan Karmen AbuZineh Shuho Nozue Aigerim Rakhmatulina Mansour Aldehaiman Asma S. Al-Amoodi Maged F. Serag Fajr A. Aleisa Jasmeen S. Merzaban Satoshi Habuchi
author_facet	Bader Al Alwan Karmen AbuZineh Shuho Nozue Aigerim Rakhmatulina Mansour Aldehaiman Asma S. Al-Amoodi Maged F. Serag Fajr A. Aleisa Jasmeen S. Merzaban Satoshi Habuchi
author_sort	Bader Al Alwan
title	Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling
title_short	Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling
title_full	Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling
title_fullStr	Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling
title_full_unstemmed	Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling
title_sort	single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db5aefcd77744f5b97409746ef597d78
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Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling

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