Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration

Abstract Type 1 diabetes is a chronic autoimmune disease that affects tens of millions of people. Diabetes mellitus is one of the strongest factors in the development of cerebrovascular diseases. In this study we used NOD.CB17 Prkdcscid mice and the pharmacological model of type 1 diabetes mellitus...

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Autores principales:	Galina Yankova, Darya Tur, Daniil Parshin, Alexander Cherevko, Andrey Akulov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/db60635b5b8647e0a374b37b0eda7cf5
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spelling	oai:doaj.org-article:db60635b5b8647e0a374b37b0eda7cf52021-12-02T10:54:23ZCerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration10.1038/s41598-021-83484-72045-2322https://doaj.org/article/db60635b5b8647e0a374b37b0eda7cf52021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83484-7https://doaj.org/toc/2045-2322Abstract Type 1 diabetes is a chronic autoimmune disease that affects tens of millions of people. Diabetes mellitus is one of the strongest factors in the development of cerebrovascular diseases. In this study we used NOD.CB17 Prkdcscid mice and the pharmacological model of type 1 diabetes mellitus of different duration to study changes in the cerebral vasculature. We used two combined approaches using magnetic resonance angiography both steady and transient CFD blood flow modeling. We identified the influence of type 1 diabetes on the architectonics and hemodynamics of the large blood vessels of the brain as the disease progresses. For the first time, we detected a statistically significant change in angioarchitectonics (the angles between the vessels of the circle of Willis, cross-sections areas of vessels) and hemodynamic (maximum blood flow rate, hydraulic resistance) in animals with diabetes duration of 2 months, that is manifested by the development of asymmetry of cerebral blood flow. The result shows the negative effect of diabetes on cerebral circulation as well as the practicability of CFD modeling. This may be of extensive interest, in pharmacological and preclinical studies.Galina YankovaDarya TurDaniil ParshinAlexander CherevkoAndrey AkulovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Galina Yankova Darya Tur Daniil Parshin Alexander Cherevko Andrey Akulov Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration
description	Abstract Type 1 diabetes is a chronic autoimmune disease that affects tens of millions of people. Diabetes mellitus is one of the strongest factors in the development of cerebrovascular diseases. In this study we used NOD.CB17 Prkdcscid mice and the pharmacological model of type 1 diabetes mellitus of different duration to study changes in the cerebral vasculature. We used two combined approaches using magnetic resonance angiography both steady and transient CFD blood flow modeling. We identified the influence of type 1 diabetes on the architectonics and hemodynamics of the large blood vessels of the brain as the disease progresses. For the first time, we detected a statistically significant change in angioarchitectonics (the angles between the vessels of the circle of Willis, cross-sections areas of vessels) and hemodynamic (maximum blood flow rate, hydraulic resistance) in animals with diabetes duration of 2 months, that is manifested by the development of asymmetry of cerebral blood flow. The result shows the negative effect of diabetes on cerebral circulation as well as the practicability of CFD modeling. This may be of extensive interest, in pharmacological and preclinical studies.
format	article
author	Galina Yankova Darya Tur Daniil Parshin Alexander Cherevko Andrey Akulov
author_facet	Galina Yankova Darya Tur Daniil Parshin Alexander Cherevko Andrey Akulov
author_sort	Galina Yankova
title	Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration
title_short	Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration
title_full	Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration
title_fullStr	Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration
title_full_unstemmed	Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration
title_sort	cerebral arterial architectonics and cfd simulation in mice with type 1 diabetes mellitus of different duration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db60635b5b8647e0a374b37b0eda7cf5
work_keys_str_mv	AT galinayankova cerebralarterialarchitectonicsandcfdsimulationinmicewithtype1diabetesmellitusofdifferentduration AT daryatur cerebralarterialarchitectonicsandcfdsimulationinmicewithtype1diabetesmellitusofdifferentduration AT daniilparshin cerebralarterialarchitectonicsandcfdsimulationinmicewithtype1diabetesmellitusofdifferentduration AT alexandercherevko cerebralarterialarchitectonicsandcfdsimulationinmicewithtype1diabetesmellitusofdifferentduration AT andreyakulov cerebralarterialarchitectonicsandcfdsimulationinmicewithtype1diabetesmellitusofdifferentduration
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Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration

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