IMMUNOGENETIC PECULIARITIES OF IL-1Β SYNTHESIS IN THE PATIENTS WITH PROTRACTED AND CHRONIC (RECURRENT) BACTERIAL INFLAMMATION OF UPPER RESPIRATORY WAYS (RHINOSINUSITIS)

We have studied distribution of IL-1β gene allelic variants (-511C>Т polymorphism in promoter region and IL-1β +3953C>Т polymorphism in exon 5) in sixty-two patients with recurrent and protracted rhinosinusitis, as well as their intercorrelations between allele frequencies, IL-1β level...

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Autores principales:	L. F. Aznabaeva, E. R. Sharipova, N. A. Arefyeva, A. G. Zainullina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	recurrent and protracted rhinosinusitis il-1β genotype Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/db61d57876804bfcbd35bcc05b22908d
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spelling	oai:doaj.org-article:db61d57876804bfcbd35bcc05b22908d2021-11-18T08:03:39ZIMMUNOGENETIC PECULIARITIES OF IL-1Β SYNTHESIS IN THE PATIENTS WITH PROTRACTED AND CHRONIC (RECURRENT) BACTERIAL INFLAMMATION OF UPPER RESPIRATORY WAYS (RHINOSINUSITIS)1563-06252313-741X10.15789/1563-0625-2007-4-5-535-540https://doaj.org/article/db61d57876804bfcbd35bcc05b22908d2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/237https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe have studied distribution of IL-1β gene allelic variants (-511C>Т polymorphism in promoter region and IL-1β +3953C>Т polymorphism in exon 5) in sixty-two patients with recurrent and protracted rhinosinusitis, as well as their intercorrelations between allele frequencies, IL-1β levels and predisposal for reccurence of chronic rhinosinusitis (CR). DNA samples were genotyped using PCR-RFLP analysis. IL-1β production by PHA-stimulated lymphocytes were determined in the cell supernates by means of quantitative enzyme immunoassay. In majority of patients (> 70%) with CR, decreased production of IL-1β was found, irrespectively of disease recurrence. Frequency of a «low-producer» homozygous С/С genotype +3953C>Т of IL-1β gene was two-fold higher in the patients with CR than in healthy controls (OR=3.4). In patients with protracted, recurrence-free patients, this parameter showed only a tendency to increase. Decreased production of IL-1β was associated with homozygous С/С genotype +3953C>Т of IL-1β gene (OR = 3,4), whereas high levels correlated with heterozygous С/T genotype (OR = 7,6).Thus, low IL-1β production in carriers of homozygous С/*С of +3953 polymorphic locus of IL-1β gene represents a diagnostic marker reflecting a risk of recurrent disease. Hence, a pathogenesis-based therapy of purulent rhinosinusitis with protracted and recurrent clinical course is possible by means of recombinant IL-1β (e.g., Betaleukin, St.Petersburg Institute for Highly Pure Biological Preparations), being a highly effective approach which favors decreased recurrence of disorder.L. F. AznabaevaE. R. SharipovaN. A. ArefyevaA. G. ZainullinaSPb RAACIarticlerecurrent and protracted rhinosinusitisil-1βgenotypeImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 4-5, Pp 535-540 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	recurrent and protracted rhinosinusitis il-1β genotype Immunologic diseases. Allergy RC581-607
spellingShingle	recurrent and protracted rhinosinusitis il-1β genotype Immunologic diseases. Allergy RC581-607 L. F. Aznabaeva E. R. Sharipova N. A. Arefyeva A. G. Zainullina IMMUNOGENETIC PECULIARITIES OF IL-1Β SYNTHESIS IN THE PATIENTS WITH PROTRACTED AND CHRONIC (RECURRENT) BACTERIAL INFLAMMATION OF UPPER RESPIRATORY WAYS (RHINOSINUSITIS)
description	We have studied distribution of IL-1β gene allelic variants (-511C>Т polymorphism in promoter region and IL-1β +3953C>Т polymorphism in exon 5) in sixty-two patients with recurrent and protracted rhinosinusitis, as well as their intercorrelations between allele frequencies, IL-1β levels and predisposal for reccurence of chronic rhinosinusitis (CR). DNA samples were genotyped using PCR-RFLP analysis. IL-1β production by PHA-stimulated lymphocytes were determined in the cell supernates by means of quantitative enzyme immunoassay. In majority of patients (> 70%) with CR, decreased production of IL-1β was found, irrespectively of disease recurrence. Frequency of a «low-producer» homozygous С/С genotype +3953C>Т of IL-1β gene was two-fold higher in the patients with CR than in healthy controls (OR=3.4). In patients with protracted, recurrence-free patients, this parameter showed only a tendency to increase. Decreased production of IL-1β was associated with homozygous С/С genotype +3953C>Т of IL-1β gene (OR = 3,4), whereas high levels correlated with heterozygous С/T genotype (OR = 7,6).Thus, low IL-1β production in carriers of homozygous С/*С of +3953 polymorphic locus of IL-1β gene represents a diagnostic marker reflecting a risk of recurrent disease. Hence, a pathogenesis-based therapy of purulent rhinosinusitis with protracted and recurrent clinical course is possible by means of recombinant IL-1β (e.g., Betaleukin, St.Petersburg Institute for Highly Pure Biological Preparations), being a highly effective approach which favors decreased recurrence of disorder.
format	article
author	L. F. Aznabaeva E. R. Sharipova N. A. Arefyeva A. G. Zainullina
author_facet	L. F. Aznabaeva E. R. Sharipova N. A. Arefyeva A. G. Zainullina
author_sort	L. F. Aznabaeva
title	IMMUNOGENETIC PECULIARITIES OF IL-1Β SYNTHESIS IN THE PATIENTS WITH PROTRACTED AND CHRONIC (RECURRENT) BACTERIAL INFLAMMATION OF UPPER RESPIRATORY WAYS (RHINOSINUSITIS)
title_short	IMMUNOGENETIC PECULIARITIES OF IL-1Β SYNTHESIS IN THE PATIENTS WITH PROTRACTED AND CHRONIC (RECURRENT) BACTERIAL INFLAMMATION OF UPPER RESPIRATORY WAYS (RHINOSINUSITIS)
title_full	IMMUNOGENETIC PECULIARITIES OF IL-1Β SYNTHESIS IN THE PATIENTS WITH PROTRACTED AND CHRONIC (RECURRENT) BACTERIAL INFLAMMATION OF UPPER RESPIRATORY WAYS (RHINOSINUSITIS)
title_fullStr	IMMUNOGENETIC PECULIARITIES OF IL-1Β SYNTHESIS IN THE PATIENTS WITH PROTRACTED AND CHRONIC (RECURRENT) BACTERIAL INFLAMMATION OF UPPER RESPIRATORY WAYS (RHINOSINUSITIS)
title_full_unstemmed	IMMUNOGENETIC PECULIARITIES OF IL-1Β SYNTHESIS IN THE PATIENTS WITH PROTRACTED AND CHRONIC (RECURRENT) BACTERIAL INFLAMMATION OF UPPER RESPIRATORY WAYS (RHINOSINUSITIS)
title_sort	immunogenetic peculiarities of il-1β synthesis in the patients with protracted and chronic (recurrent) bacterial inflammation of upper respiratory ways (rhinosinusitis)
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/db61d57876804bfcbd35bcc05b22908d
work_keys_str_mv	AT lfaznabaeva immunogeneticpeculiaritiesofil1bsynthesisinthepatientswithprotractedandchronicrecurrentbacterialinflammationofupperrespiratorywaysrhinosinusitis AT ersharipova immunogeneticpeculiaritiesofil1bsynthesisinthepatientswithprotractedandchronicrecurrentbacterialinflammationofupperrespiratorywaysrhinosinusitis AT naarefyeva immunogeneticpeculiaritiesofil1bsynthesisinthepatientswithprotractedandchronicrecurrentbacterialinflammationofupperrespiratorywaysrhinosinusitis AT agzainullina immunogeneticpeculiaritiesofil1bsynthesisinthepatientswithprotractedandchronicrecurrentbacterialinflammationofupperrespiratorywaysrhinosinusitis
_version_	1718422573218267136

IMMUNOGENETIC PECULIARITIES OF IL-1Β SYNTHESIS IN THE PATIENTS WITH PROTRACTED AND CHRONIC (RECURRENT) BACTERIAL INFLAMMATION OF UPPER RESPIRATORY WAYS (RHINOSINUSITIS)

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