In Vivo Evaluation of PVP-Gelatin-Chitosan Composite Blended with Egg-Yolk Oil for Radiodermatitis

Radiation-induced skin injury (RSI) is a frequent complication of radiotherapy. Severe cases affect the patient’s disease treatment and quality of life. The main purpose of this study is to examine the causative role of egg-yolk oil (EYO) in delayed radiation-induced skin injury, including impaired...

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Autores principales:	Yi-Chi Hung, Shu-Chih Hsieh, Syuan-Ren Hou, Jui-Yin Kung, Cheng-Ming Tang, Chen-Jung Chang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chitosan gelatin polyvinylpyrrolidone egg-yolk oil radiodermatitis wound healing Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/db6381efa6ee47069a9e00c74ea1fb8e
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spelling	oai:doaj.org-article:db6381efa6ee47069a9e00c74ea1fb8e2021-11-11T15:19:16ZIn Vivo Evaluation of PVP-Gelatin-Chitosan Composite Blended with Egg-Yolk Oil for Radiodermatitis10.3390/app1121102902076-3417https://doaj.org/article/db6381efa6ee47069a9e00c74ea1fb8e2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/10290https://doaj.org/toc/2076-3417Radiation-induced skin injury (RSI) is a frequent complication of radiotherapy. Severe cases affect the patient’s disease treatment and quality of life. The main purpose of this study is to examine the causative role of egg-yolk oil (EYO) in delayed radiation-induced skin injury, including impaired wound healing. Using polyvinyl pyrrolidone (PVP)-gelatin-chitosan (PGC) composite film as controlled release of egg-yolk oil (EYO) was studied in rats, which were used as a radiation-induced skin injury model. Different composition ratios were tested for their mechanical properties, moisture content, and degradation characteristics. The results showed that the PGC112 (<i>w</i>/<i>w</i>) substrate, which will hence be referred to as PGC, had the better properties. Further, the PGC was mixed with EYO (0.25% and 0.5%) to prepare the films (PGC/0.25EYO and PGC/0.5EYO, respectively). Furthermore, the mechanical and degradation properties and biocompatibility showed better results with PGC/0.5EYO. In animal studies, rats were irradiated with single-dose electron beams of 40 Gy. The animals were divided into five groups to perform wound treatment with various types of wound dressing for 30 days. Histological examination and CD68 immunochemical staining were then conducted, and observations were made. The results showed that PGC/0.5EYO has a significantly healing effects on radiodermatitis and good re-epithelialization.Yi-Chi HungShu-Chih HsiehSyuan-Ren HouJui-Yin KungCheng-Ming TangChen-Jung ChangMDPI AGarticlechitosangelatinpolyvinylpyrrolidoneegg-yolk oilradiodermatitiswound healingTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10290, p 10290 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chitosan gelatin polyvinylpyrrolidone egg-yolk oil radiodermatitis wound healing Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	chitosan gelatin polyvinylpyrrolidone egg-yolk oil radiodermatitis wound healing Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Yi-Chi Hung Shu-Chih Hsieh Syuan-Ren Hou Jui-Yin Kung Cheng-Ming Tang Chen-Jung Chang In Vivo Evaluation of PVP-Gelatin-Chitosan Composite Blended with Egg-Yolk Oil for Radiodermatitis
description	Radiation-induced skin injury (RSI) is a frequent complication of radiotherapy. Severe cases affect the patient’s disease treatment and quality of life. The main purpose of this study is to examine the causative role of egg-yolk oil (EYO) in delayed radiation-induced skin injury, including impaired wound healing. Using polyvinyl pyrrolidone (PVP)-gelatin-chitosan (PGC) composite film as controlled release of egg-yolk oil (EYO) was studied in rats, which were used as a radiation-induced skin injury model. Different composition ratios were tested for their mechanical properties, moisture content, and degradation characteristics. The results showed that the PGC112 (<i>w</i>/<i>w</i>) substrate, which will hence be referred to as PGC, had the better properties. Further, the PGC was mixed with EYO (0.25% and 0.5%) to prepare the films (PGC/0.25EYO and PGC/0.5EYO, respectively). Furthermore, the mechanical and degradation properties and biocompatibility showed better results with PGC/0.5EYO. In animal studies, rats were irradiated with single-dose electron beams of 40 Gy. The animals were divided into five groups to perform wound treatment with various types of wound dressing for 30 days. Histological examination and CD68 immunochemical staining were then conducted, and observations were made. The results showed that PGC/0.5EYO has a significantly healing effects on radiodermatitis and good re-epithelialization.
format	article
author	Yi-Chi Hung Shu-Chih Hsieh Syuan-Ren Hou Jui-Yin Kung Cheng-Ming Tang Chen-Jung Chang
author_facet	Yi-Chi Hung Shu-Chih Hsieh Syuan-Ren Hou Jui-Yin Kung Cheng-Ming Tang Chen-Jung Chang
author_sort	Yi-Chi Hung
title	In Vivo Evaluation of PVP-Gelatin-Chitosan Composite Blended with Egg-Yolk Oil for Radiodermatitis
title_short	In Vivo Evaluation of PVP-Gelatin-Chitosan Composite Blended with Egg-Yolk Oil for Radiodermatitis
title_full	In Vivo Evaluation of PVP-Gelatin-Chitosan Composite Blended with Egg-Yolk Oil for Radiodermatitis
title_fullStr	In Vivo Evaluation of PVP-Gelatin-Chitosan Composite Blended with Egg-Yolk Oil for Radiodermatitis
title_full_unstemmed	In Vivo Evaluation of PVP-Gelatin-Chitosan Composite Blended with Egg-Yolk Oil for Radiodermatitis
title_sort	in vivo evaluation of pvp-gelatin-chitosan composite blended with egg-yolk oil for radiodermatitis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/db6381efa6ee47069a9e00c74ea1fb8e
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In Vivo Evaluation of PVP-Gelatin-Chitosan Composite Blended with Egg-Yolk Oil for Radiodermatitis

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