The protective effect of Satureja bachtiarica hydroalcoholic extract on streptozotocin‐induced diabetes through modulating glucose transporter 2 and 4 expression and inhibiting oxidative stress

Context: Oxidative stress plays an important role in development of diabetes mellitus. Satureja bachtiarica Bunge (Lamiaceae) is a rich source of bioactive compounds with antioxidant properties. Objective: This study investigates the antidiabetic effect of hydroalcoholic extract of aerial parts of S...

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Autores principales:	Reyhaneh Joudaki, Mahbubeh Setorki
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	satureja bachtiarica diabetes streptozotocine oxidative stress glucose transporter Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/db63b3f950bc496ab2d7e2e430b1bc12
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spelling	oai:doaj.org-article:db63b3f950bc496ab2d7e2e430b1bc122021-11-17T14:21:56ZThe protective effect of Satureja bachtiarica hydroalcoholic extract on streptozotocin‐induced diabetes through modulating glucose transporter 2 and 4 expression and inhibiting oxidative stress1388-02091744-511610.1080/13880209.2019.1597131https://doaj.org/article/db63b3f950bc496ab2d7e2e430b1bc122019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2019.1597131https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Oxidative stress plays an important role in development of diabetes mellitus. Satureja bachtiarica Bunge (Lamiaceae) is a rich source of bioactive compounds with antioxidant properties. Objective: This study investigates the antidiabetic effect of hydroalcoholic extract of aerial parts of S. bachtiarica. Methods and materials: Male Wistar rats were randomly divided into six groups (n = 8) including control (normal saline), diabetic [Streptozotocin (STZ)], intervention (STZ plus hydroalcoholic extract of S. bachtiarica at doses of 75, 150 and 250 mg/kg/d) and positive control (STZ plus captopril 50 mg/kg/d) groups. A single intraperitoneal (IP) injection of STZ (60 mg/kg) was used to induce diabetes and IP therapy with drugs was performed for four weeks. Results: In diabetic rats, serum total antioxidant capacity (TAC) decreased significantly, but glucose, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT) and malondialdehyde (MDA) increased significantly as compared to the control (p < 0.05). Treatment with extract (250 mg/kg) caused a significant decline in serum glucose, GGT, ALT, AST and MDA as well as a significant increase in serum TAC (p < 0.05). During the intervention period, diabetic rats showed significant weight loss, but extract (250 mg/kg) treated rats did not show any weight loss. Extract (250 mg/kg) up-regulated GLUT2 expression and down-regulated GLUT4 expression in the liver (p < 0.05). S. bachtiarica extract at all dosage levels prevented STZ-induced histological damage of liver, kidney and pancreas. Discussion and conclusions: S. bachtiarica extract exhibits antidiabetic effects through modulation of oxidative stress and expression of GLUT2 and GLUT4.Reyhaneh JoudakiMahbubeh SetorkiTaylor & Francis Grouparticlesatureja bachtiaricadiabetesstreptozotocineoxidative stressglucose transporterTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 318-327 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	satureja bachtiarica diabetes streptozotocine oxidative stress glucose transporter Therapeutics. Pharmacology RM1-950
spellingShingle	satureja bachtiarica diabetes streptozotocine oxidative stress glucose transporter Therapeutics. Pharmacology RM1-950 Reyhaneh Joudaki Mahbubeh Setorki The protective effect of Satureja bachtiarica hydroalcoholic extract on streptozotocin‐induced diabetes through modulating glucose transporter 2 and 4 expression and inhibiting oxidative stress
description	Context: Oxidative stress plays an important role in development of diabetes mellitus. Satureja bachtiarica Bunge (Lamiaceae) is a rich source of bioactive compounds with antioxidant properties. Objective: This study investigates the antidiabetic effect of hydroalcoholic extract of aerial parts of S. bachtiarica. Methods and materials: Male Wistar rats were randomly divided into six groups (n = 8) including control (normal saline), diabetic [Streptozotocin (STZ)], intervention (STZ plus hydroalcoholic extract of S. bachtiarica at doses of 75, 150 and 250 mg/kg/d) and positive control (STZ plus captopril 50 mg/kg/d) groups. A single intraperitoneal (IP) injection of STZ (60 mg/kg) was used to induce diabetes and IP therapy with drugs was performed for four weeks. Results: In diabetic rats, serum total antioxidant capacity (TAC) decreased significantly, but glucose, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT) and malondialdehyde (MDA) increased significantly as compared to the control (p < 0.05). Treatment with extract (250 mg/kg) caused a significant decline in serum glucose, GGT, ALT, AST and MDA as well as a significant increase in serum TAC (p < 0.05). During the intervention period, diabetic rats showed significant weight loss, but extract (250 mg/kg) treated rats did not show any weight loss. Extract (250 mg/kg) up-regulated GLUT2 expression and down-regulated GLUT4 expression in the liver (p < 0.05). S. bachtiarica extract at all dosage levels prevented STZ-induced histological damage of liver, kidney and pancreas. Discussion and conclusions: S. bachtiarica extract exhibits antidiabetic effects through modulation of oxidative stress and expression of GLUT2 and GLUT4.
format	article
author	Reyhaneh Joudaki Mahbubeh Setorki
author_facet	Reyhaneh Joudaki Mahbubeh Setorki
author_sort	Reyhaneh Joudaki
title	The protective effect of Satureja bachtiarica hydroalcoholic extract on streptozotocin‐induced diabetes through modulating glucose transporter 2 and 4 expression and inhibiting oxidative stress
title_short	The protective effect of Satureja bachtiarica hydroalcoholic extract on streptozotocin‐induced diabetes through modulating glucose transporter 2 and 4 expression and inhibiting oxidative stress
title_full	The protective effect of Satureja bachtiarica hydroalcoholic extract on streptozotocin‐induced diabetes through modulating glucose transporter 2 and 4 expression and inhibiting oxidative stress
title_fullStr	The protective effect of Satureja bachtiarica hydroalcoholic extract on streptozotocin‐induced diabetes through modulating glucose transporter 2 and 4 expression and inhibiting oxidative stress
title_full_unstemmed	The protective effect of Satureja bachtiarica hydroalcoholic extract on streptozotocin‐induced diabetes through modulating glucose transporter 2 and 4 expression and inhibiting oxidative stress
title_sort	protective effect of satureja bachtiarica hydroalcoholic extract on streptozotocin‐induced diabetes through modulating glucose transporter 2 and 4 expression and inhibiting oxidative stress
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/db63b3f950bc496ab2d7e2e430b1bc12
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The protective effect of Satureja bachtiarica hydroalcoholic extract on streptozotocin‐induced diabetes through modulating glucose transporter 2 and 4 expression and inhibiting oxidative stress

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