The interactions between dietary fats intake and Caveolin 1 rs 3807992 polymorphism with fat distribution in overweight and obese women: a cross-sectional study
Abstract Background It has been reported that dietary fats and genetic factors in individuals are associated with the pattern of fat distribution. This study aimed to evaluate the interaction between dietary fats intake and Caveolin1 (CAV-1) rs 3807s992 polymorphism with fat distribution in overweig...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
BMC
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/db66ef7f258a4507ad88e5408233e0eb |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:db66ef7f258a4507ad88e5408233e0eb |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:db66ef7f258a4507ad88e5408233e0eb2021-11-14T12:07:43ZThe interactions between dietary fats intake and Caveolin 1 rs 3807992 polymorphism with fat distribution in overweight and obese women: a cross-sectional study10.1186/s12920-021-01114-71755-8794https://doaj.org/article/db66ef7f258a4507ad88e5408233e0eb2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12920-021-01114-7https://doaj.org/toc/1755-8794Abstract Background It has been reported that dietary fats and genetic factors in individuals are associated with the pattern of fat distribution. This study aimed to evaluate the interaction between dietary fats intake and Caveolin1 (CAV-1) rs 3807s992 polymorphism with fat distribution in overweight and obese women. Methods A total of 221 participants were included in the current cross-sectional study. Body composition, biochemical parameters were evaluated by body composition analyzer and Pars Azmoon kits and genotypes determination was performed by PCR–RFLP, dietary fats were measured using a validated semi-quantitative food frequency questionnaire (FAQ). Results The frequency of GG, AA and AG genotypes were 53.1, 24.6, and 22.3%, respectively, and the mean intake of total dietary fat intake was 97.47 ± 36.87 g. There was positive significant interaction between total fat intake and AA genotype on visceral fat level (p = 0.001), trunk fat (p = 0.01) and waist circumference (p = 0.05), positive significant interaction between total fat intake and AG genotype on the waist to hip ratio (WHR) (p = 0.02) and visceral fat level (p = 0.05), positive borderline significant interaction between saturated fatty acid and AA genotype on the trunk fat (p = 0.06), and between trans-fatty acids and AG genotype on WHR (p = 0.04), visceral fat level (p = 0.01), and between monounsaturated fatty acid and AG genotype on WHR (p = 0.04), and a borderline interaction between polyunsaturated fatty acid and AA genotypes on visceral fat level (p = 0.06), negative significant interaction between AG genotypes and linolenic acid on WHR (p = 0.04), borderline significant interaction between ALA and AG genotype on WHR (p = 0.06). Conclusions Our findings showed that CAV-1 rs 3807992 polymorphism and dietary fats were associated with fat distributions in individuals.Yasaman AaliFarideh ShirasebFaezeh AbajFariba koohdaniKhadijeh MirzaeiBMCarticleObesityDietary fatsFat distributionBody compositionCaveolaCaveolin 1Internal medicineRC31-1245GeneticsQH426-470ENBMC Medical Genomics, Vol 14, Iss 1, Pp 1-27 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Obesity Dietary fats Fat distribution Body composition Caveola Caveolin 1 Internal medicine RC31-1245 Genetics QH426-470 |
| spellingShingle |
Obesity Dietary fats Fat distribution Body composition Caveola Caveolin 1 Internal medicine RC31-1245 Genetics QH426-470 Yasaman Aali Farideh Shiraseb Faezeh Abaj Fariba koohdani Khadijeh Mirzaei The interactions between dietary fats intake and Caveolin 1 rs 3807992 polymorphism with fat distribution in overweight and obese women: a cross-sectional study |
| description |
Abstract Background It has been reported that dietary fats and genetic factors in individuals are associated with the pattern of fat distribution. This study aimed to evaluate the interaction between dietary fats intake and Caveolin1 (CAV-1) rs 3807s992 polymorphism with fat distribution in overweight and obese women. Methods A total of 221 participants were included in the current cross-sectional study. Body composition, biochemical parameters were evaluated by body composition analyzer and Pars Azmoon kits and genotypes determination was performed by PCR–RFLP, dietary fats were measured using a validated semi-quantitative food frequency questionnaire (FAQ). Results The frequency of GG, AA and AG genotypes were 53.1, 24.6, and 22.3%, respectively, and the mean intake of total dietary fat intake was 97.47 ± 36.87 g. There was positive significant interaction between total fat intake and AA genotype on visceral fat level (p = 0.001), trunk fat (p = 0.01) and waist circumference (p = 0.05), positive significant interaction between total fat intake and AG genotype on the waist to hip ratio (WHR) (p = 0.02) and visceral fat level (p = 0.05), positive borderline significant interaction between saturated fatty acid and AA genotype on the trunk fat (p = 0.06), and between trans-fatty acids and AG genotype on WHR (p = 0.04), visceral fat level (p = 0.01), and between monounsaturated fatty acid and AG genotype on WHR (p = 0.04), and a borderline interaction between polyunsaturated fatty acid and AA genotypes on visceral fat level (p = 0.06), negative significant interaction between AG genotypes and linolenic acid on WHR (p = 0.04), borderline significant interaction between ALA and AG genotype on WHR (p = 0.06). Conclusions Our findings showed that CAV-1 rs 3807992 polymorphism and dietary fats were associated with fat distributions in individuals. |
| format |
article |
| author |
Yasaman Aali Farideh Shiraseb Faezeh Abaj Fariba koohdani Khadijeh Mirzaei |
| author_facet |
Yasaman Aali Farideh Shiraseb Faezeh Abaj Fariba koohdani Khadijeh Mirzaei |
| author_sort |
Yasaman Aali |
| title |
The interactions between dietary fats intake and Caveolin 1 rs 3807992 polymorphism with fat distribution in overweight and obese women: a cross-sectional study |
| title_short |
The interactions between dietary fats intake and Caveolin 1 rs 3807992 polymorphism with fat distribution in overweight and obese women: a cross-sectional study |
| title_full |
The interactions between dietary fats intake and Caveolin 1 rs 3807992 polymorphism with fat distribution in overweight and obese women: a cross-sectional study |
| title_fullStr |
The interactions between dietary fats intake and Caveolin 1 rs 3807992 polymorphism with fat distribution in overweight and obese women: a cross-sectional study |
| title_full_unstemmed |
The interactions between dietary fats intake and Caveolin 1 rs 3807992 polymorphism with fat distribution in overweight and obese women: a cross-sectional study |
| title_sort |
interactions between dietary fats intake and caveolin 1 rs 3807992 polymorphism with fat distribution in overweight and obese women: a cross-sectional study |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/db66ef7f258a4507ad88e5408233e0eb |
| work_keys_str_mv |
AT yasamanaali theinteractionsbetweendietaryfatsintakeandcaveolin1rs3807992polymorphismwithfatdistributioninoverweightandobesewomenacrosssectionalstudy AT faridehshiraseb theinteractionsbetweendietaryfatsintakeandcaveolin1rs3807992polymorphismwithfatdistributioninoverweightandobesewomenacrosssectionalstudy AT faezehabaj theinteractionsbetweendietaryfatsintakeandcaveolin1rs3807992polymorphismwithfatdistributioninoverweightandobesewomenacrosssectionalstudy AT faribakoohdani theinteractionsbetweendietaryfatsintakeandcaveolin1rs3807992polymorphismwithfatdistributioninoverweightandobesewomenacrosssectionalstudy AT khadijehmirzaei theinteractionsbetweendietaryfatsintakeandcaveolin1rs3807992polymorphismwithfatdistributioninoverweightandobesewomenacrosssectionalstudy AT yasamanaali interactionsbetweendietaryfatsintakeandcaveolin1rs3807992polymorphismwithfatdistributioninoverweightandobesewomenacrosssectionalstudy AT faridehshiraseb interactionsbetweendietaryfatsintakeandcaveolin1rs3807992polymorphismwithfatdistributioninoverweightandobesewomenacrosssectionalstudy AT faezehabaj interactionsbetweendietaryfatsintakeandcaveolin1rs3807992polymorphismwithfatdistributioninoverweightandobesewomenacrosssectionalstudy AT faribakoohdani interactionsbetweendietaryfatsintakeandcaveolin1rs3807992polymorphismwithfatdistributioninoverweightandobesewomenacrosssectionalstudy AT khadijehmirzaei interactionsbetweendietaryfatsintakeandcaveolin1rs3807992polymorphismwithfatdistributioninoverweightandobesewomenacrosssectionalstudy |
| _version_ |
1718429437151674368 |