Engineering of Long-Circulating Peptidoglycan Hydrolases Enables Efficient Treatment of Systemic <named-content content-type="genus-species">Staphylococcus aureus</named-content> Infection

Engineering of Long-Circulating Peptidoglycan Hydrolases Enables Efficient Treatment of Systemic <named-content content-type="genus-species">Staphylococcus aureus</named-content> Infection

ABSTRACT Staphylococcus aureus is a human pathogen causing life-threatening diseases. The increasing prevalence of multidrug-resistant S. aureus infections is a global health concern, requiring development of novel therapeutic options. Peptidoglycan-degrading enzymes (peptidoglycan hydrolases, PGHs)...

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Autores principales: Anna M. Sobieraj, Markus Huemer, Léa V. Zinsli, Susanne Meile, Anja P. Keller, Christian Röhrig, Fritz Eichenseher, Yang Shen, Annelies S. Zinkernagel, Martin J. Loessner, Mathias Schmelcher
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
endolysin
protein therapeutic
antibiotic resistance
MRSA
circulation half-life
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/db6d42fc26334af090638c286d488157
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