Multi-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy

WIPI proteins are mammalian PROPPIN family phosphoinositide effectors that recognize a WIPI-interacting-region (WIR)-motif to recruit other regulators during autophagosome formation. Here, the authors combine structural and functional studies and present the crystal structure of human WIPI3 with a b...

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Autores principales:	Jinqi Ren, Ruobing Liang, Wenjuan Wang, Dachuan Zhang, Li Yu, Wei Feng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db704a1b9bd64094a44afc4f6fbb4ddb
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spelling	oai:doaj.org-article:db704a1b9bd64094a44afc4f6fbb4ddb2021-12-02T15:57:09ZMulti-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy10.1038/s41467-020-16523-y2041-1723https://doaj.org/article/db704a1b9bd64094a44afc4f6fbb4ddb2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16523-yhttps://doaj.org/toc/2041-1723WIPI proteins are mammalian PROPPIN family phosphoinositide effectors that recognize a WIPI-interacting-region (WIR)-motif to recruit other regulators during autophagosome formation. Here, the authors combine structural and functional studies and present the crystal structure of human WIPI3 with a bound ATG2A WIR-peptide and observe that the WIR-motif binds to three sites in blades 1-3 of WIPI3 and mutating these binding sites impairs the ATG2A-mediated autophagic process.Jinqi RenRuobing LiangWenjuan WangDachuan ZhangLi YuWei FengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinqi Ren Ruobing Liang Wenjuan Wang Dachuan Zhang Li Yu Wei Feng Multi-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy
description	WIPI proteins are mammalian PROPPIN family phosphoinositide effectors that recognize a WIPI-interacting-region (WIR)-motif to recruit other regulators during autophagosome formation. Here, the authors combine structural and functional studies and present the crystal structure of human WIPI3 with a bound ATG2A WIR-peptide and observe that the WIR-motif binds to three sites in blades 1-3 of WIPI3 and mutating these binding sites impairs the ATG2A-mediated autophagic process.
format	article
author	Jinqi Ren Ruobing Liang Wenjuan Wang Dachuan Zhang Li Yu Wei Feng
author_facet	Jinqi Ren Ruobing Liang Wenjuan Wang Dachuan Zhang Li Yu Wei Feng
author_sort	Jinqi Ren
title	Multi-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy
title_short	Multi-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy
title_full	Multi-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy
title_fullStr	Multi-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy
title_full_unstemmed	Multi-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy
title_sort	multi-site-mediated entwining of the linear wir-motif around wipi β-propellers for autophagy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/db704a1b9bd64094a44afc4f6fbb4ddb
work_keys_str_mv	AT jinqiren multisitemediatedentwiningofthelinearwirmotifaroundwipibpropellersforautophagy AT ruobingliang multisitemediatedentwiningofthelinearwirmotifaroundwipibpropellersforautophagy AT wenjuanwang multisitemediatedentwiningofthelinearwirmotifaroundwipibpropellersforautophagy AT dachuanzhang multisitemediatedentwiningofthelinearwirmotifaroundwipibpropellersforautophagy AT liyu multisitemediatedentwiningofthelinearwirmotifaroundwipibpropellersforautophagy AT weifeng multisitemediatedentwiningofthelinearwirmotifaroundwipibpropellersforautophagy
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Multi-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy

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