Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes

Female meiotic divisions are asymmetric with the formation of large oocytes and small polar bodies, thought to result from cortical spindle placement before anaphase. The authors find that Cdk1 inactivation triggers F-actin dependent post-anaphase spindle migration, resulting in cortical protrusion.

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Autores principales:	Zhe Wei, Jessica Greaney, Chenxi Zhou, Hayden A. Homer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db71a765213d4b4e883beac5d9417968
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spelling	oai:doaj.org-article:db71a765213d4b4e883beac5d94179682021-12-02T14:39:43ZCdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes10.1038/s41467-018-06510-92041-1723https://doaj.org/article/db71a765213d4b4e883beac5d94179682018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06510-9https://doaj.org/toc/2041-1723Female meiotic divisions are asymmetric with the formation of large oocytes and small polar bodies, thought to result from cortical spindle placement before anaphase. The authors find that Cdk1 inactivation triggers F-actin dependent post-anaphase spindle migration, resulting in cortical protrusion.Zhe WeiJessica GreaneyChenxi ZhouHayden A. HomerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhe Wei Jessica Greaney Chenxi Zhou Hayden A. Homer Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes
description	Female meiotic divisions are asymmetric with the formation of large oocytes and small polar bodies, thought to result from cortical spindle placement before anaphase. The authors find that Cdk1 inactivation triggers F-actin dependent post-anaphase spindle migration, resulting in cortical protrusion.
format	article
author	Zhe Wei Jessica Greaney Chenxi Zhou Hayden A. Homer
author_facet	Zhe Wei Jessica Greaney Chenxi Zhou Hayden A. Homer
author_sort	Zhe Wei
title	Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes
title_short	Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes
title_full	Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes
title_fullStr	Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes
title_full_unstemmed	Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes
title_sort	cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/db71a765213d4b4e883beac5d9417968
work_keys_str_mv	AT zhewei cdk1inactivationinducespostanaphaseonsetspindlemigrationandmembraneprotrusionrequiredforextremeasymmetryinmouseoocytes AT jessicagreaney cdk1inactivationinducespostanaphaseonsetspindlemigrationandmembraneprotrusionrequiredforextremeasymmetryinmouseoocytes AT chenxizhou cdk1inactivationinducespostanaphaseonsetspindlemigrationandmembraneprotrusionrequiredforextremeasymmetryinmouseoocytes AT haydenahomer cdk1inactivationinducespostanaphaseonsetspindlemigrationandmembraneprotrusionrequiredforextremeasymmetryinmouseoocytes
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Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes

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