Efficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine A

Mitchell A Jackson1, Kim Burrell2, Ian B Gaddie3, Shana D Richardson4 1Jacksoneye, Lake Villa, IL, USA; 2Centennial Eye Associates, Centennial, CO, USA; 3Gaddie Eye Centers, Louisville, KY, USA; 4CYNACON/OCuSOFT, Richmond, TX, USA Purpose: To evaluate the effect of a new, prescription-only medical f...

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Autores principales:	Richardson SD, Gaddie IB, Burrell K, Jackson MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/db74e56f709f4ba3a5c06d98163d3beb
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spelling	oai:doaj.org-article:db74e56f709f4ba3a5c06d98163d3beb2021-12-02T02:41:45ZEfficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine A1177-54671177-5483https://doaj.org/article/db74e56f709f4ba3a5c06d98163d3beb2011-08-01T00:00:00Zhttp://www.dovepress.com/efficacy-of-a-new-prescription-only-medical-food-supplement-in-allevia-a8148https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Mitchell A Jackson1, Kim Burrell2, Ian B Gaddie3, Shana D Richardson4 1Jacksoneye, Lake Villa, IL, USA; 2Centennial Eye Associates, Centennial, CO, USA; 3Gaddie Eye Centers, Louisville, KY, USA; 4CYNACON/OCuSOFT, Richmond, TX, USA Purpose: To evaluate the effect of a new, prescription-only medical food supplement containing omega-3 and omega-6 essential fatty acids on dry eye signs and symptoms, with or without concomitant topical cyclosporine. Methods: A total of 43 subjects were randomized and followed for 6 months. Group 1 (n = 23) was assigned to take two soft geltabs of the medical food supplement by mouth twice daily for 6 months. Group 2 (n = 20) was directed to take the medical food supplement in the same manner, along with topical cyclosporine, instilled twice daily during the last 3 months of the study. Subjects were evaluated at baseline, month 1, month 3, and month 6. Primary outcome measures included tear breakup time (TBUT), conjunctival staining, corneal staining, and change in subjective symptoms. Results: Both groups had a statistically significant improvement in TBUT between baseline and month 6. In the food supplement only group, TBUT improved by 0.805 seconds from baseline to month 6. In the supplement/cyclosporine group, TBUT improved by 1.007 seconds from baseline. There was no statistically significant difference in TBUT between the two groups at baseline, month 3, or month 6. There were no significant differences in corneal or conjunctival staining between or within groups. Subjective symptoms were also improved in both groups. Conclusion: Supplementation with the proper balance of omega-3 and omega-6 essential fatty acids improved TBUT and relieved patient symptoms. The addition of topical cyclosporine did not convey any statistically significant improvement in TBUT beyond that achieved by the supplement. Keywords: omega-3, omega-6, essential fatty acids, TBUT, tear breakup time&nbsp;Richardson SDGaddie IBBurrell KJackson MADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1201-1206 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Richardson SD Gaddie IB Burrell K Jackson MA Efficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine A
description	Mitchell A Jackson1, Kim Burrell2, Ian B Gaddie3, Shana D Richardson4 1Jacksoneye, Lake Villa, IL, USA; 2Centennial Eye Associates, Centennial, CO, USA; 3Gaddie Eye Centers, Louisville, KY, USA; 4CYNACON/OCuSOFT, Richmond, TX, USA Purpose: To evaluate the effect of a new, prescription-only medical food supplement containing omega-3 and omega-6 essential fatty acids on dry eye signs and symptoms, with or without concomitant topical cyclosporine. Methods: A total of 43 subjects were randomized and followed for 6 months. Group 1 (n = 23) was assigned to take two soft geltabs of the medical food supplement by mouth twice daily for 6 months. Group 2 (n = 20) was directed to take the medical food supplement in the same manner, along with topical cyclosporine, instilled twice daily during the last 3 months of the study. Subjects were evaluated at baseline, month 1, month 3, and month 6. Primary outcome measures included tear breakup time (TBUT), conjunctival staining, corneal staining, and change in subjective symptoms. Results: Both groups had a statistically significant improvement in TBUT between baseline and month 6. In the food supplement only group, TBUT improved by 0.805 seconds from baseline to month 6. In the supplement/cyclosporine group, TBUT improved by 1.007 seconds from baseline. There was no statistically significant difference in TBUT between the two groups at baseline, month 3, or month 6. There were no significant differences in corneal or conjunctival staining between or within groups. Subjective symptoms were also improved in both groups. Conclusion: Supplementation with the proper balance of omega-3 and omega-6 essential fatty acids improved TBUT and relieved patient symptoms. The addition of topical cyclosporine did not convey any statistically significant improvement in TBUT beyond that achieved by the supplement. Keywords: omega-3, omega-6, essential fatty acids, TBUT, tear breakup time&nbsp;
format	article
author	Richardson SD Gaddie IB Burrell K Jackson MA
author_facet	Richardson SD Gaddie IB Burrell K Jackson MA
author_sort	Richardson SD
title	Efficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine A
title_short	Efficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine A
title_full	Efficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine A
title_fullStr	Efficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine A
title_full_unstemmed	Efficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine A
title_sort	efficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine a
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/db74e56f709f4ba3a5c06d98163d3beb
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Efficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine A

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