The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

SMARCB1 inactivation is prevalent in human atypical teratoid/rhabdoid tumours but a mouse model that accurately phenocopies the human disease is lacking. Here, the authors show that inactivation of SMARCB1between E6 and E10 in mice results in tumours that better recapitulate the human phenotype, com...

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Autores principales:	Zhi-Yan Han, Wilfrid Richer, Paul Fréneaux, Céline Chauvin, Carlo Lucchesi, Delphine Guillemot, Camille Grison, Delphine Lequin, Gaelle Pierron, Julien Masliah-Planchon, André Nicolas, Dominique Ranchère-Vince, Pascale Varlet, Stéphanie Puget, Isabelle Janoueix-Lerosey, Olivier Ayrault, Didier Surdez, Olivier Delattre, Franck Bourdeaut
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db7502ce51b84400a57d9b5dd944a70e
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spelling	oai:doaj.org-article:db7502ce51b84400a57d9b5dd944a70e2021-12-02T16:49:26ZThe occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation10.1038/ncomms104212041-1723https://doaj.org/article/db7502ce51b84400a57d9b5dd944a70e2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10421https://doaj.org/toc/2041-1723SMARCB1 inactivation is prevalent in human atypical teratoid/rhabdoid tumours but a mouse model that accurately phenocopies the human disease is lacking. Here, the authors show that inactivation of SMARCB1between E6 and E10 in mice results in tumours that better recapitulate the human phenotype, compared to previously reported models.Zhi-Yan HanWilfrid RicherPaul FréneauxCéline ChauvinCarlo LucchesiDelphine GuillemotCamille GrisonDelphine LequinGaelle PierronJulien Masliah-PlanchonAndré NicolasDominique Ranchère-VincePascale VarletStéphanie PugetIsabelle Janoueix-LeroseyOlivier AyraultDidier SurdezOlivier DelattreFranck BourdeautNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhi-Yan Han Wilfrid Richer Paul Fréneaux Céline Chauvin Carlo Lucchesi Delphine Guillemot Camille Grison Delphine Lequin Gaelle Pierron Julien Masliah-Planchon André Nicolas Dominique Ranchère-Vince Pascale Varlet Stéphanie Puget Isabelle Janoueix-Lerosey Olivier Ayrault Didier Surdez Olivier Delattre Franck Bourdeaut The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation
description	SMARCB1 inactivation is prevalent in human atypical teratoid/rhabdoid tumours but a mouse model that accurately phenocopies the human disease is lacking. Here, the authors show that inactivation of SMARCB1between E6 and E10 in mice results in tumours that better recapitulate the human phenotype, compared to previously reported models.
format	article
author	Zhi-Yan Han Wilfrid Richer Paul Fréneaux Céline Chauvin Carlo Lucchesi Delphine Guillemot Camille Grison Delphine Lequin Gaelle Pierron Julien Masliah-Planchon André Nicolas Dominique Ranchère-Vince Pascale Varlet Stéphanie Puget Isabelle Janoueix-Lerosey Olivier Ayrault Didier Surdez Olivier Delattre Franck Bourdeaut
author_facet	Zhi-Yan Han Wilfrid Richer Paul Fréneaux Céline Chauvin Carlo Lucchesi Delphine Guillemot Camille Grison Delphine Lequin Gaelle Pierron Julien Masliah-Planchon André Nicolas Dominique Ranchère-Vince Pascale Varlet Stéphanie Puget Isabelle Janoueix-Lerosey Olivier Ayrault Didier Surdez Olivier Delattre Franck Bourdeaut
author_sort	Zhi-Yan Han
title	The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation
title_short	The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation
title_full	The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation
title_fullStr	The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation
title_full_unstemmed	The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation
title_sort	occurrence of intracranial rhabdoid tumours in mice depends on temporal control of smarcb1 inactivation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/db7502ce51b84400a57d9b5dd944a70e
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The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

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